Role in fast inactivation of the IV:S4-S5 loop of the human muscle Na+ channel probed by cysteine mutagenesis

Journal of Physiology

Volumn 505, Issue 2, 1997, Pages 345-352

  Lerche, H ^a   Peter, W ^a   Fleischhauer, R ^a   Pika Hartlaub, U ^a   Malina, T ^a   Mitrovic, N ^a   Lehmann Horn, F ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; SODIUM CHANNEL; SODIUM ION; THIOL REAGENT; AMINO ACID; COMPLEMENTARY DNA; THIOL DERIVATIVE; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE POTENTIAL; HUMAN; HUMAN CELL; HYPERPOLARIZATION; KIDNEY CELL; MUTAGENESIS; MUTANT; PATCH CLAMP; PRIORITY JOURNAL; SODIUM CURRENT; ALPHA HELIX; CELL MEMBRANE; CONTROLLED STUDY; MEMBRANE POTENTIAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STEADY STATE; WHOLE CELL PATCH CLAMP; WILD TYPE;

ADULT; AMINO ACID SUBSTITUTION; CELL LINE; CYSTEINE; EMBRYO; HUMANS; INDICATORS AND REAGENTS; KIDNEY; KINETICS; MESYLATES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; SODIUM CHANNELS; SULFHYDRYL REAGENTS;

EID: 0031450948     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.345bb.x     Document Type: Article

References (21)

1. + channel. II. Gating current experiments. Journal of General Physiology 70, 567-590.
2. + channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron 12, 281-294.
3. CHEN, L. Q., SANTARELLI, V., HORN, R. & KALLEN, R. G. (1996). A unique role for the S4 segment of domain 4 in the inactivation of sodium channels. Journal of General Physiology 108, 549-556.
4. FILATOV, G. N., KRANER, S. D. & BARCHI, R. L. (1997). Secondary structure of the D4/S4-5 linker probed by systematic cysteine accessibility method. Biophysical Journal 72, A260.
5. + channel. Journal of General Physiology 108, 195-206.
6. + channel inactivation. Science 250, 533-538.
7. + channel. Nature 353, 86-90.
8. + channel inactivation gate during inactivation. Journal of Biological Chemistry 271, 30971-30979.
9. + channels. Journal of General Physiology 109, 589-605.
10. LEHMANN-HORN, F. & RÜDEL, R. (1997). Channelopathies: Contributions to our knowledge about voltage-gated ion channels. News in Physiological Sciences 12, 105-112.
11. + channel mutation in adult human skeletal muscle. Annals of Neurology 39, 599-608.
12. + channel α-subunit in fast inactivation. Biophysical Journal 70, A318.
13. + channel by the V1589M mutation. Journal of Physiology 478, 395-402.
14. + channel. Neuroscience Letters 214, 9-12.
15. + channel. Neuron 11, 967-974.
16. SMITH, M. R., YU, E. J. & GOLDIN, A. L. (1997). Interaction between the putative sodium channel inactivation particle and domain III S4-S5. Biophysical Journal 72, A261.
17. STAUFFER, D. A. & KARLIN, A. (1994). Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates. Biochemistry 33, 6840-6849.
18. + channel. Nature 339, 597-603.
19. TANG, L. & KALLEN, R. G. (1997). Mutations in cytoplasmic portions of sodium channels affecting inactivation: S4-5 segments. Biophysical Journal 72, A260.
20. + channel inactivation. Proceedings of the National Academy of Sciences of the USA 89, 10910-10914.
21. YANG, N., GEORGE, A. L. & HORN, R. (1996). Molecular basis of charge movement in voltage-gated sodium channels. Neuron 16, 113-122.