Role in fast inactivation of conserved amino acids in the IV/S4-S5 loop of the human muscle Na+ channel

Neuroscience Letters

Volumn 214, Issue 1, 1996, Pages 9-12

  Mitrovic, N ^a   Lerche, H ^a   Heine, R ^a   Fleischhauer, R ^a   Pika Hartlaub, U ^a   Hartlaub, U ^a   George Jr , A L ^b   Lehmann Horn, F ^a  

^a UNIVERSITY OF ULM   (Germany)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Human; Inactivation; Myotonia; Na+ channel; Patch clamp; Skeletal muscle

Indexed keywords

SODIUM CHANNEL;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HUMAN; MUSCLE CELL; MUTATION; MYOTONIA; PATCH CLAMP; PRIORITY JOURNAL;

EID: 0030590205     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)12866-4     Document Type: Article

References (11)

1. + channel II. Gating current experiments, J. Gen. Physiol., 70 (1977) 567-590.
2. [2] Hoffman, E.P., Lehmann-Horn, F. and Rüdel, R., Over-excited or inactive: ion channels in muscle disease, Cell, 80 (1995) 681-686.
3. + channel inactivation, Science, 250 (1990) 533-538.
4. + channel, Nature, 353 (1991) 86-90.
5. + channel mutation in adult human skeletal muscle, Ann. Neurol., 39 (1996) 599-608.
6. + channel α-subunit in fast inactivation, Biophys. J., 70 (1996) A318.
7. + channel, J. Physiol., 478 (1994) 395-402.
8. [8] Mitrovic, N., George, A.L. Jr., Lerche, H., Wagner, S., Fahlke, Ch. and Lehmann-Horn, F., Different effects on gating of three myotonia-causing mutations in the inactivation gate of the human muscle sodium channel, J. Physiol., 487 (1995) 107-114.
9. + channel, Neuron, 11 (1993) 967-974.
10. + channel inactivation, Proc. Natl. Acad. Sci. USA, 89 (1992) 10910-10914.
11. + channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro, Proc. Natl. Acad. Sci. USA, 91 (1994) 12785-12789.