Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies

Journal of Endocrinology

Volumn 198, Issue 3, 2008, Pages 489-497

  Sakai, Noriko ^a   Terami, Hiromi ^a   Suzuki, Shinobu ^a   Haga, Megumi ^a   Nomoto, Ken ^a   Tsuchida, Nobuko ^a   Morohashi, Ken Ichirou ^b   Saito, Naoaki ^c   Asada, Maki ^d   Hashimoto, Megumi ^d   Harada, Daisuke ^d   Asahara, Hiroshi ^d   Ishikawa, Tetsuya ^a   Shimada, Fumiki ^a   Sakurada, Kazuhiro ^a  

^a BAYER YAKUHIN LTD   (Japan)

^b NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^c KOBE UNIVERSITY   (Japan)

^d NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; ADENOVIRUS VECTOR; CENTROMERE PROTEIN; COMPLEMENTARY DNA; GENE PRODUCT; HEXOKINASE 2; JOSEPHIN DOMAIN CONTAINING 1 PROTEIN; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; PROTEIN ERB B3; PROTEIN KIAA1257; PROTEIN KINASE C DELTA; PROTEIN NR5A1; PROTEIN RHOGAP; SEX DETERMINING REGION Y BOX 15 PROTEIN; SMALL INTERFERING RNA; TATA BINDING PROTEIN ASSOCIATED FACTOR 5 LIKE RNA POLYMERASE; TEA DOMAIN FAMILY MEMBER 4 PROTEIN; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETIC SCREENING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN GENOME; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; PLASMID; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ADENOVIRIDAE; ANIMALS; CATTLE; CELL LINE; CELLS, CULTURED; CHROMOSOMAL PROTEINS, NON-HISTONE; CYCLIC AMP; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENE LIBRARY; GENETIC VECTORS; GTPASE-ACTIVATING PROTEINS; HEXOKINASE; HUMANS; MESENCHYMAL STEM CELLS; MUSCLE PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C-DELTA; RECEPTOR, ERBB-3; RNA, SMALL INTERFERING; SOX TRANSCRIPTION FACTORS; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTORS;

EID: 53349127742     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0027     Document Type: Article

References (45)

1. Anbanandam A, Albarado DC, Nguyen CT, Haider G, Gao X & Veeraraghavan S 2006 Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain. PNAS 103 17225-17230.
2. Assou S, Anahory T, Pantesco V, Le Carrour T, Pellestor F, Klein B, Reyftmann L, Dechaud H, De Vos J & Hamamah S 2006 The human cumulus-oocyte complex gene-expression profile. Human Reproduction 21 1705-1719.
3. van Berkel ME & Oosterwegel MA 2006 CD28 and ICOS: similar or separate costimulators of T cells? Immunology Letters 105 115-122.
4. Berkholtz CB, Shea LD & Woodruff TK 2006 Extracellular matrix functions in follicle maturation. Seminars in Reproductive Medicine 24 262-269.
5. Broekmans FJ, Knauff EA, te Velde ER, Macklon NS & Fauser BC 2007 Female reproductive ageing: current knowledge and future trends. Trends in Endocrinology and Metabolism 18 58-65.
6. Brown HM, Dunning KR, Robker RL, Pritchard M & Russell DL 2006 Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. Developmental Biology 300 699-709.
7. Bukulmez O & Arici A 2000 Leukocytes in ovarian function. Human Reproduction Update 6 1-15.
8. Chan EY, Kir S & Tooze SA 2007 siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. Journal of Biological Chemistry 282 25464-25474.
9. Cirigliano M 2007 Bioidentical hormone therapy: a review of the evidence. Journal of Women's Health 16 600-631.
10. Clyne CD, Speed CJ, Zhou J & Simpson ER 2002 Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. Journal of Biological Chemistry 277 20591-20597.
11. Crawford PA, Sadovsky Y & Milbrandt J 1997 Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage. Molecular and Cellular Biology 17 3997-4006.
12. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA & Messing RO 2000 Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology 279 L429-L438.
13. Gondo S, Yanase T, Okabe T, Tanaka T, Morinaga H, Nomura M, Goto K & Nawata H 2004 NF5A1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells. Genes to Cells 9 1239-1247.
14. Harris AN & Mellon PL 1999 The basic helix-loop-helix, leucine, zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of NF5A1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Molecular Endocrinology 12 714-726.
15. Hiraoka Y, Ogawa M, Sakai Y, Taniguchi K, Fujii T, Umezawa A, Hata J & Aiso S 1998 Isolation and expression of a human SRY-related cDNA hSOX20. Biochimica et Biophysica Acta 1396 132-137.
16. Honda A, Hirose M, Hara K, Matoba S, Inoue K, Miki H, Hiura H, Kanatsu-Shinohara M, Kanai Y, Kono T et al. 2007 Isolation, characterization, and in vitro and in vivo differentiation of putative thecal stem cells. PNAS 104 12389-12394.
17. Jacquemin P, Hwang JJ, Martial JA, Dollé P & Davidson I 1996 A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. Journal of Biological Chemistry 271 21775-21785.
18. Kawabe K, Shikayama T, Tsuboi H, Oka S, Oba K, Yanase T, Nawata H & Morohashi K 1999 Dax-1 as one ofthe target genes of Ad4BP/NF5A1. Molecular Endocrinology 13 1267-1284.
19. Kitano H 2007 A robustness-based approach to systems-oriented drug design. Nature Reviews. Drug Discovery 6 202-210.
20. Liu Z, Liu X, Nakayama KI, Nakayama K & Ye K 2007 Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival. Journal of Neurochemistry 100 1278-1288.
21. Magoffin DA 2005 Ovarian theca cell. International Journal of Biochemistry and Cell Biology 37 1344-1349.
22. Mendelson CR & Kamat A 2007 Mechanisms in the regulation of aromatase in developing ovary and placenta. Journal of Steroid Biochemistry and Molecular Biology 106 62-70.
23. Minguell JJ, Erices A & Conget P 2001 Mesenchymal stern cells. Experimental Biology and Medicine 226 507-520.
24. Monté D, De Witte F & Hum DW 1998 Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300. Journal of Biological Chemistry 273 4585-4591.
25. Morohashi K, Honda S, Inomata Y, Handa H & Omura T 1992 A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. Journal of Biological Chemistry 267 17913-17919.
26. Nomura M, Nawata H & Morohashi K 1996 Autoregulatory loop in the regulation of the mammalian ftz-f1 gene. Journal of Biological Chemistry 271 8243-8249.
27. Osaki E, Nishina Y, Inazawa J, Copeland NG, Gilbert DJ, Jenkins NA, Ohsugi M, Tezuka T, Yoshida M & Sernba K 1999 Identification of a novel Sry-related gene and its germ cell specific expression. Nucleic Acids Research 27 2503-2510.
28. Palter SF, Tavares AB, Hourvitz A, Veldhuis JD & Adashi EY 2001 Are estrogens of import to primate/human ovarian folliculogenesis? Endocrine Reviews 22 389-424.
29. Park JY, Su YQ, Ariga M, Law E, Jin SL & Conti M 2004 EGF-like growth factors as mediators ofLH action in the ovulatory follicle. Science 303 682-684.
30. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC et al. 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. Journal of the American Medical Association 288 321-333.
31. Sarraj MA, Wilmore HP, McClive PJ & Sinclair AH 2003 SOX15 is up regulated in the embryonic mouse testis. Gene Expression Patterns 3 413-417.
32. Saxena D, Escamilla-Hernandez R, Little-Ihrig L & Zeleznik AJ 2007 Liver receptor homolog-1 and steroidogenic factor-1 have similar actions on rat granulosa cell steroidogenesis. Endocrinology 148 726-734.
33. Scherrer SP, Rice DA & Heckert LL 2002 Expression of steroidogenic factor 1 in the testis requires an interactive array of elements within its proximal promoter. Biology of Reproduction 67 1509-1521.
34. Shen JH & Ingraham HA 2002 Regulation of the orphan nuclear receptor steroidogenic factor 1 by SOX proteins. Molecular Endocrinology 16 529-540.
35. Simpson ER & Davis SR 2001 Minireview: aromatase and the regulation of estrogen biosynthesis - some new perspectives. Endocrinology 142 4589-4594.
36. Tanaka T, Gondo S, Okabe T, Ohe K, Shirohzu H, Morinaga H, Nomura M, Tani K, Takayanagi R, Nawata H et al. 2007 Steroidogenic factor 1/ adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells. Journal of Molecular Endocrinology 39 343-350.
37. Thompson M, Andrade VA, Andrade SJ, Pusl T, Ortega JM, Goes AM & Leire MF 2003 Inhibition of the TEF/TEAD transcription factor activity by nuclear calcium and distinct kinase pathways. Biochemical and Biophysical Research Communications 301 267-274.
38. Tyner JW, Walters DK, Willis SG, Luttropp, M, Oost J, Loriaux M, Erickson H, Corbin AS, O'Hare T, Heinrich MC et al. 2008 RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood 111 2238-2245.
39. Val P, Lefrançois-Martinez AM, Veyssière G & Martinez A 2003 NF5A1 a key player in the development and differentiation of steroidogenic tissues. Nuclear Receptor 1 8.
40. Vanderhyden B 2002 Molecular basis of ovarian development and function. Frontiers in Bioscience 7 d2006-d2022.
41. Weck J & Mayo KE 2006 Switching of NR5A proteins associated with the inhibin alpha-subunit gene promoter after activation of the gene in granulosa cells. Molecular Endocrinology 20 1090-1103.
42. Woods DC & Johnson AL 2007 Protein kinase C activity mediates LH-induced ErbB/Erk signaling in differentiated hen granulosa cells. Reproduction 133 733-741.
43. Yazawa T, Mizutani T, Yamada K, Kawata H, Sekiguchi T, Yoshinc M, Kajitani T, Shou Z, Umezawa A & Miyamoto K 2006 Differentiation of adult stem cells derived from bone marrow stroma into Leydig or adrenocortical cells. Endocrinology 147 4104-4111.
44. Zhou J, Gurates B, Yang S, Sebastian S & Bulun SE 2001 Malignant breast epithelial cells stimulate aromatase expression via Promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein. Cancer Research 61 2328-2334.
45. de Ziegler D, Fraisse T, de Candolle G, Vulliemoz N, Bellavia M & Colamaria S 2007 Outlook: roles of FSH and LH during the follicular phase: insight into natural cycle IVF. Reproductive Biomedicine Online 15 507-513.