Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5451-5455

  Carlton, David L ^a   Collin Smith, Lissa J ^a   Daniels, Alejandro J ^a   Deaton, David N ^a   Goetz, Aaron S ^a   Laudeman, Christopher P ^a   Littleton, Thomas R ^a   Musso, David L ^a   Morgan, Ronda J Ott ^a   Szewczyk, Jerzy R ^a   Zhang, Cunyu ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

BB3; Bombesin; Bombesin receptor subtype 3 agonist; BRS 3; G Protein coupled seven transmembrane receptor modulation; Omeprazole; Orphan seven transmembrane receptor

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; BENZIMIDAZOLE; BOMBESIN RECEPTOR; BOMBESIN RECEPTOR SUBTYPE 3 AGONIST; OMEPRAZOLE; PYRIDINE; SULFIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CROSS LINKING; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; NONHUMAN; PHARMACOPHORE; SUBSTITUTION REACTION;

BACULOVIRIDAE; BENZIMIDAZOLES; BRAIN; CHEMISTRY, PHARMACEUTICAL; CHLOROFLUOROCARBONS, METHANE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; MODELS, CHEMICAL; OMEPRAZOLE; PYRIDINES; RECEPTORS, BOMBESIN; SULFIDES;

BOVINE RESPIRATORY SYNCYTIAL VIRUS;

EID: 53349103137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.033     Document Type: Article

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25. 50 = 0.55 nM in this assay.
26. 50 = 0.060 nM in this assay.