The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5350-5354

  Bazin, Hélène G ^a   Murray, Tim J ^a   Bowen, William S ^a   Mozaffarian, Afsaneh ^a   Fling, Steven P ^a   Bess, Laura S ^a   Livesay, Mark T ^a   Arnold, Jeffrey S ^a   Johnson, Craig L ^a   Ryter, Kendal T ^a   Cluff, Christopher W ^a   Evans, Jay T ^a   Johnson, David A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

AGP; Glycolipids; Immunostimulants; Lipid A mimetics; Reductive alkylation; TLR4 agonist; TLR4 antagonist

Indexed keywords

CRX 526; CRX 527; ETHER LIPID; GLUCOSAMINE DERIVATIVE; GLYCOLIPID; IMMUNOMODULATING AGENT; LIPID A; MYRISTIC ACID DERIVATIVE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CELL ASSAY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VIVO STUDY; INFLUENZA; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GLUCOSAMINE; GLYCOLIPIDS; HUMANS; INHIBITORY CONCENTRATION 50; LIPID A; LIPIDS; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MONOCYTES; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 53349102955     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.060     Document Type: Article

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