Clinical efficacy and pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in patients with falciparum malaria

British Journal of Clinical Pharmacology

Volumn 41, Issue 6, 1996, Pages 587-592

  Hassan Alin, M ^a,b   Ashton, M ^a   Kihamia, C M ^c   Mtey, G J B ^d   Bjorkman A ^b,e  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^d Kibaha Designated District Hospital   (Tanzania)

^e DANDERYD HOSPITAL   (Sweden)

Author keywords

artemisinin; efficacy pharmacokinetics; mefloquine; Plasmodium falciparum malaria

Indexed keywords

ARTEMISIN; FANSIDAR; MEFLOQUINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MIXTURE; DRUG SAFETY; DYSPHORIA; FEMALE; FEVER; HUMAN; INSOMNIA; MALARIA FALCIPARUM; MALE; ORAL DRUG ADMINISTRATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PRURITUS; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS;

EID: 8944263309     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1996.35116.x     Document Type: Article

References (21)

1. Chawira AN, Warhurst DC. The effect of artemisinin combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro. J Trop Med Hyg 1987; 90: 1-8.
2. Chawira AN, Warhurst DC, Robinsson BL, Peters W. The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice. Trans R Soc Trop Med Hyg 1987; 81: 554-558.
3. Win K, Than M, Thwe Y. Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus tetracycline for treating cerebral malaria. Bull W H O 1992; 70: 777-782.
4. Looareesuwan S, Viravan C, Vanijanonta S, et al. Randomized trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria. Lancet 1992; 339: 821-824.
5. Looareesuwan S, Kyle DE, Viravan C, et al. Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine. Am J Trop Med Hyg 1992; 47: 794-799.
6. Looareesuwan S, Viravan C, Vanijanonta S. et al. Treatment of acute uncomplicated falciparum malaria with a short course of artesunate followed by mefloquine. Southeast Asian J Trop Med Public Health 1993; 24: 230-234.
7. Hien TT, Arnold K, Hung NT, et al. Single dose artemisinin-mefloquine treatment for acute uncomplicated. Trans R Soc Trop Med 1994; 88: 688-691.
8. Titulaer H A C, Zuidema J, Kager P A, et al. The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J Pharm Pharmacol 1990; 42: 810-813.
9. Due DD, De Vries PJ, Khanh NX, et al. The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. Am J Trop Med Hyg 1994; 5: 785-790.
10. Loutan L, Paris M, Plessas C. et al. Pharmacokinetics of artemisinin after oral administration in healthy volunteers. Am J Trop Med Hyg 1993; 49 abstract 281.
11. Edlund P O, Westerlund D, Carlqvist J, et al. Determination of artesunate and dihydroartemisinin in plasma by liquid chromatography with post-column derivatization and UV-detection. Acta Pharm Suec 1984; 21: 223-234.
12. Li GQ, Guo XB, Fu LC. et al. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Trans R Soc Trop Med Hyg 1994; 88: 5-6.
13. Bunnag D, Viravan C, Looareesuwan S, et al. Clinical trial of artesunate and artemether on multildrug resistant falciparum malaria in Thailand. Southeast Asian J Trop Med Public Health 1991; 22: 380-385.
14. Bunnag D, Viravan C, Looareesuwan S, et al. Double blind randomized clinical trial of oral artesunate once or twice daily dose in falciparum malaria. Southeast Asian J Trop Med Public Health 1991; 22: 539-543.
15. Bunnag D, Karbwang J, Harinasuta T. Artemether in the treatment of multiple drug resistant falciparum malaria. Southeast Asian J Trop Med Public Health 1992; 23: 762-767.
16. Sy ND, Hoan DB, Dung NP, et al. Treatment of malaria in Vietnam with oral artemisinin. Am J Trop Med Hyg 1993; 48:398-402.
17. Hassan Alin M, Kihamia C M, Björkman A, et al. Efficacy after oral and intravenous artesunate in male Tanzanian adults with Plasmodium falciparum malaria and in vitro susceptibility to artemisinin, chloroquine and mefloquine. Am J Trop Med Hyg 1995; 53: 639-645.
18. Niu Xinyi, Ho Liyi, Ren Zhihong, Song Zhenyu. Metabolic fate of Qinghaosu in rats; a new TLC densitometric method for its determination in biological material. Eur J Drug Metab Pharmacokinet 1985; 10: 55-59.
19. Na Bangchang K, Karbwang J, Back DJ. Mefloquine metabolism by human liver microsomes, effect of other antimalarial drugs. Biochem Pharmacol 1992; 43: 1957-1961.
20. Karbwang J, Na Bangchang K, Thanavibul A, et al. Pharmacokinetics of mefloquine when given alone and in combination with artesunate. Bull WHO 1994; 72: 226-229.
21. Patchen JH, Campbell CC. Williams SB. Neurological reactions after a therapeutic dose of mefloquine. N Engl J Med 1989; 325: 1415-1416.