Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 90, Issue 1, 1996, Pages 61-65

  Hassan Alin, M ^a,b   Ashton, M ^a   Kihamia, C M ^c   Mtey, G J B ^d   Bjorkman A ^b,e  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^d Kibaha Designated District Hospital   (Tanzania)

^e DANDERYD HOSPITAL   (Sweden)

Author keywords

Artemisinin; Artesunate; Chemotherapy; Malaria; Plasmodium falciparum; Tanzania

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTESUNATE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; FEVER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALARIA FALCIPARUM; ORAL DRUG ADMINISTRATION; PARASITEMIA; RANDOMIZED CONTROLLED TRIAL; ULTRAVIOLET RADIATION;

ARTESUNATE; PLASMODIUM FALCIPARUM;

EID: 0030028396     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(96)90480-0     Document Type: Article

References (12)

1. Basco, L. K. & Le Bras, J. (1993). In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene, 49, 301-307.
2. Dao Dinh Duc, De Vries, P. J., Nguyen Xuan Khanh, Le Nguyen Binh, Kager, P. A. & Van Boxtel, C. J. (1994). The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. American Journal of Tropical Medicine and Hygiene, 51, 785-790.
3. Edlund, P. O., Westerlund, D., Wu Bo-Liang, Jin Yunhua & Carlqvist, J. (1984). Determination of artesunate and dihydroartemisinin in plasma by liquid chromatography with post-column derivatization and UV-detection. Acta Pharmaceutica Suecica, 21, 223-234.
4. Hassan Alin, M., Björkman, A. & Ashton, M. (1990). In vitro activity of artemisinin, its derivatives, and pyronaridine against different strains of Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, 635-637.
5. Hassan Alin, M., Björkman, A., Landberg-Lindgren, A. & Ashton, M. (1992). The effect of artemisinin, its derivatives and mefloquine against chloroquine-resistant strains of Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 365-367.
6. Leskovac, V. & Peggins, J. O., III (1992). Hepatic metabolism of artemisinin drugs-III. Induction of hydrogen peroxide production in rat liver microsomes by artemisinin drugs. Comparative Biochemistry and Physiology, 101 C, 203-208.
7. Leskovac, V. & Theoharides, A. D. (1991). Hepatic metabolism of artemisinin drugs-I. Drug metabolism in rat liver microsomes. Comparative Biochemistry and Physiology, 99 C, 383-390.
8. Li, Z. L., Gu, H. M., Warhurst, D. C. & Peters, W. (1983). Effects of qinghaosu and related compounds on incorporation of [G- H]hypoxanthine by Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 77, 522-523.
9. Loutan, L., Paris, M., Plessas, C., Benakis, A. & Andrial, M. (1993). Pharmacokinetics of artemisinin after oral administration in healthy volunteers. American Journal of Tropical Medicine and Hygiene, 49, supplement, abstract 281, p. 236.
10. Silamut, K., Molunto, P., Ho, M., Davis, T. M. E. & White, N. J. (1991). α1-Acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria. British Journal of Clinical Pharmacology, 32, 311-315.
11. Titulacr, H. A. C., Zuidema, J., Kager, P. A., Wetsteyn, J. C. F. M., Lugt, Ch. B. & Merkus, F. W. H. M. (1990). The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. Journal of Pharmaceutical Pharmacology, 42, 810-813.
12. Tran Tinh Hien, Arnold, K., Ha Vinh, Bui Minh Cuong, Nguyen Hoan Phu, Tran Thi Hong Chau, Nguyen Thi Mong Hoa, Ly Van Chuong, Nguyen Thi Hoang Mai, Nguyen Ngoc Vinh & Tran Thi My Trang (1992). Comparison of artemisinin suppositories with intravenous artesunate and intravenous quinine in the treatment of cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 582-583.