Dorsal root ganglion neurons induce transdifferentiation of mesenchymal stem cells along a Schwann cell lineage

Neuroscience Letters

Volumn 445, Issue 3, 2008, Pages 246-251

  Yang, Jinsong ^a   Lou, Qiang ^a   Huang, Renzheng ^a   Shen, Longxiang ^a   Chen, Zhengrong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Co culture; Dorsal root ganglion neurons; Mesenchymal stem cells; Schwann cells; Transdifferentiation

Indexed keywords

MYELIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL STRUCTURE; MALE; MESENCHYMAL STEM CELL; MYELINATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL; SPINAL GANGLION; TRANSDIFFERENTIATION;

ANIMALS; CELL DIFFERENTIATION; CELL SHAPE; CELLS, CULTURED; COCULTURE TECHNIQUES; GANGLIA, SPINAL; GREEN FLUORESCENT PROTEINS; MALE; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN BASIC PROTEINS; NERVE TISSUE PROTEINS; NEURONS; RATS; RATS, WISTAR; SCHWANN CELLS; TIME FACTORS; TRANSFECTION;

EID: 53249140208     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.09.015     Document Type: Article

References (23)

1. Akiyama Y., Honmou O., Kato T., Uede T., Hashi K., and Kocsis J.D. Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord. Exp. Neurol. 167 (2001) 27-39
2. Akiyama Y., Radtke C., Honmou O., and Kocsis J.D. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 39 (2002) 229-236
3. Azizi S.A., Stokes D., Augelli B.J., DiGirolamo C., and Prockop D.J. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts. Proc. Natl. Acad. Sci. 95 (1998) 3908-3913
4. Brazelton T.R., Rossi F.M., Keshet G.I., and Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290 (2000) 1775-1779
5. Brockes J.P., Fields K.L., and Raff M.C. Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain. Res. 165 (1979) 105-118
6. Brustle O., Jones K.N., Learish R.D., Karram K., Choudhary K., Wiestler O.D., Duncan I.D., and McKay R.D. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 285 (1999) 754-756
7. Bunge R.P., Bunge M.B., and Bates M. Movements of the Schwann cell nucleus implicate progression of the inner (axon-related) Schwann cell process during myelination. J. Cell Biol. 109 (1989) 273-284
8. Dezawa M., Takahashi I., Esaki M., Takano M., and Sawada H. Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur. J. Neurosci. 14 (2001) 1171-1176
9. Eglitis M.A., Dawson D., Park K.W., and Mouradian M.M. Targeting of marrow-derived astrocytes to the ischemic brain. NeuroReport 10 (1999) 1289-1292
10. Honmou O., Felts P.A., Waxman S.G., and Kocsis J.D. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells. J. Neurosci. 16 (1996) 3199-3208
11. Kamada T., Koda M., Dezawa M., Yoshinaga K., Hishimoto M., Koshizuka S., Nishio Y., Moriya H., and Yamazaki M. Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J. Neuropathol. Exp. Neurol. 64 (2005) 37-45
12. Kashofer K., and Bonnet D. Gene therapy progress and prospects: stem cell plasticity. Gene Ther. 12 (2005) 1229-1234
13. Kopen G.C., Prockop D.J., and Phinney D.G. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl. Acad. Sci. 96 (1999) 10711-10716
14. Mezey E., Chandross K.J., Harta G., Maki R.A., and McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290 (2000) 1779-1782
15. Oswald J., Boxberger S., Jorgensen B., Feldmann S., Ehninger G., Bornhauser M., and Werner C. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22 (2004) 377-384
16. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., and Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
17. Pittenger M.F., and Martin B.J. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ. Res. 95 (2004) 9-20
18. Plant G.W., Currier P.F., Cuervo E.P., Bates M.L., Pressman Y., Bunge M.B., and Wood P.M. Purified adult ensheathing glia fail to myelinate axons under culture conditions that enable Schwann cells to form myelin. J. Neurosci. 22 (2002) 6083-6091
19. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
20. Rutenberg M.S., Hamazaki T., Singh A.M., and NTerada. Stem cell plasticity, beyond alchemy. Int. J. Hematol. 79 (2004) 15-21
21. Sasaki M., Honmou O., Akiyama Y., Uede T., Hashi K., and Kocsis J.D. Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 35 (2001) 26-34
22. Woodbury D., Schwarz E.J., Prockop D.J., and Black I.B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61 (2000) 364-370
23. Zanazzi G., Einheber S., Westreich R., Hannocks M.J., Bedell- Hogan D., Marchionni M.A., and Salzer J.L. Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination. J. Cell Biol. 152 (2001) 1289-1299