Effects of substitutions of lysine and aspartic acid for asparagine at β108 and of tryptophan for valine at α96 on the structural and functional properties of human normal adult hemoglobin: Roles of α1β1 and α1β1 subunit interfaces in the cooperative oxygenation process

Biochemistry

Volumn 38, Issue 27, 1999, Pages 8751-8761

  Tsai, Ching Hsuan ^a   Shen, Tong Jian ^a   Ho, Nancy T ^a   Ho, Chien ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; ASPARTIC ACID; HEMOGLOBIN; LYSINE; RECOMBINANT PROTEIN; TRYPTOPHAN; VALINE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BOHR EFFECT; ESCHERICHIA COLI; HEMOGLOBIN ANALYSIS; NONHUMAN; OXYGEN AFFINITY; OXYGENATION; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

2,3-DIPHOSPHOGLYCERATE; ADULT; AMINO ACID SUBSTITUTION; ASPARAGINE; ASPARTIC ACID; BUFFERS; CHLORIDES; HEMOGLOBIN A; HEMOGLOBINS; HEMOGLOBINS, ABNORMAL; HEPES; HUMANS; LYSINE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXYGEN; OXYHEMOGLOBINS; PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN; VALINE;

EID: 0033529307     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990286o     Document Type: Article

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