Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women

European Journal of Endocrinology

Volumn 159, Issue 3, 2008, Pages 233-241

  Lambrinoudaki, Irene ^a   Kaparos, George ^a   Papadimitriou, Dimitra ^a   Sergentanis, Theodoros N ^a   Creatsa, Maria ^a   Aexandrou, Andreas ^b   Logothetis, Emmanuel ^a   Christodoulakos, George ^a   Kouskouni, E ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALANINE; ANDROGEN; ANDROSTENEDIONE; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ARYLDIALKYLPHOSPHATASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN B1; CHOLESTEROL ESTER TRANSFER PROTEIN B2; CYTOSINE; ESTRADIOL; ESTROGEN; FOLLITROPIN; GLYCOPROTEIN B; GLYCOPROTEIN IIIA; HOMOCYSTEINE; LEUCINE; LUTEINIZING HORMONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRASTERONE SULFATE; PROLINE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TYROSINE; UNCLASSIFIED DRUG; VALINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ABDOMINAL OBESITY; ADULT; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CENTRAL OBESITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; WAIST HIP RATIO; WILD TYPE; WOMEN'S HEALTH; GENETIC PREDISPOSITION; GENETICS; GONADAL DISEASE; MIDDLE AGED; OBESITY; PHYSIOLOGY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOSITY; AGED; BODY MASS INDEX; CARDIOVASCULAR DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; RISK FACTORS; VIRILISM; WAIST-HIP RATIO;

EID: 53249090615     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/EJE-07-0848     Document Type: Article

References (35)

1. Gaspard UJ, Gottal JM & van den Brûle FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas 1995 21 171-178.
2. Rosario GM, Vitale C, Marazzi G & Volterrani M. Menopause and cardiovascular disease: the evidence. Climacteric 2007 10(Suppl 1) 19-24.
3. Zamboni M, Armellini F, Milani MP, De Marchi M, Todesco T, Robbi R, Bergamo-Andreis IA & Bosello O. Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. International Journal of Obesity and Related Metabolic Disorders 1992 16 495-504.
4. Misra KB, Endemann SW & Ayer M. Measures of obesity and metabolic syndrome in Indian Americans in northern California. Ethnicity & Disease 2006 16 331-337.
5. Dalton M, Cameron AJ, Zimmet PZ, Shaw JE, Jolley D, Dunstan DW & Welborn TA. Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. Journal of Internal Medicine 2003 254 555-563.
6. Wild RA. Obesity, lipids, cardiovascular risk, and androgen excess. American Journal of Medicine 1995 98 27S-32S.
7. Lee CC, Kasa-Vubu. JZ & Supiano MA. Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal women. Metabolism 2004 53 507-512.
8. Christodoulakos G, Lambrinoudaki I, Panoulis C, Sioulas V, Rizos D, Caramalis G, Botsis D & Creatsas G. Serum androgen levels and insulin resistance in postmenopausal women: association with hormone therapy, tibolone and raloxifene. Maturitas 2005 50 321-330.
9. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss IL, Gerstenblith G & Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. New England Journal of Medicine 1996 334 1090-1094.
10. Cubrilo-Turek M, Stavlienić-Rukavina A, Sertić J, Zrinski R, Turek S, Grgac G & Ljubojević N. Apolipoprotein E genotypes and metabolic risk factors for coronary heart disease in middle-aged women. Collegium Antropologicum 1998 22 149-155.
11. Sánchez-Marín B & Grasa JM. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in ischemic vascular disease. Revista de Neurologia 2006 43 630-636.
12. Tybjaerg-Hansen A, Steffensen R, Meinertz H, Schnohr P & Nordestgaard BG. Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease. New England Journal of Medicine 1998 338 1577-1584.
13. Chen Q, Reis SE, Kammerer CM, McNamara DM, Holubkov R, Sharaf BL, Sopko G, Pauly DF, Merz CN & Kamboh MI. WISE Study Group. Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. American Journal of Human Genetics 2003 72 13-22.
14. Martínez-Calatrava W, Martínez-Larrad MT, Zabena C, González-Sánchez JL, Fernández-Pérez C & Scrrano-Ríos M. The 4G/4G PAI-1 genotype is associated with elevated plasma PAI-1 levels regardless of variables of the metabolic syndrome and smoking status. A population-based study in Spanish population. Diabetes, Obesity and Metabolism 2007 9 134-135.
15. Couture P, Otvos JD, Cupples LA, Wilson PWF, Schaefer EJ & Ordovas JM. Association of the A-204C polymorphism in the cholesterol 7-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. Journal of Lipid Research 1999 40 1883-1889.
16. Ordovas JM, Cupples LA, Corella D, Otvos JD, Osgood D, Martinez A, Lahoz C, Coltell O, Wilson PW & Schaefer EJ. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 1323-1329.
17. Guzelmeric K, Alkan N, Pirimoglou M, Unal O & Turan C. Chronic inflammation and elevated homocystcine levels are associated with increased body mass index in women with polycystic ovary. Gynecological Endocrinology 2007 23 505-510.
18. Huemer M, Vonblon K, Fodinger M, Krumpholz R, Hubmann M, Ulmer H & Simma B. Total homocysteine, folate and cobalamine, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents. Pediatric Research 2006 60 764-769.
19. Kawamoto R, Kohara K, Oka Y, Tomita H, Tabara Y & Miki T. An association of 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke. Journal of Stroke and Cerebrovascular Diseases 2005 14 67-74.
20. Couturaud F, Oger E, Abalain JH, Cherm E, Guias B, Floch HH, Mercier B, Mottier D & Leroyer C. Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease. Respiration 2000 67 657-661.
21. Villa P, Soriano R, Costantini B, Macrí F, Ricciardi L, Campagna G & Lanzone A. Hyperhomocysteinemia and cardiovascular risk in postmenopausal women: the rote of folate supplementation. Clinical Chemistry and Laboratory Medicine 2007 45 130-135.
22. Wierzbicki AS. Homocysteine and cardiovascular disease: a review of the evidence. Diabetes and Vascular Disease Research 2007 4 143-149.
23. Carlsen SM, Kjotrod S, Vanky E & Romundstad P. Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome. Acta Obstetricia et Gynecologica Scandinavica 2007 86 145-150.
24. Giltay EJ, Hoogeven EK, Elbers JMH, Gooren LJG, Asscheman H & Stehouwer CDA. Insulin resistance is associated with elevated plasma total homocysteine levels in healthy, non-obese subjects. Atherosclerosis 1998 139 197-198.
25. McCarty MF. Insulin secretion as a potential determinant of homocysteine levels. Medical Hypotheses 2000 55 454-455.
26. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O & Ron-EI R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated homocysteine. Human Reproduction 2003 18 721-727.
27. Bjorck J, Hellgren M, Rastam L & Lindblad U. Associations between serum insulin and homocysteine in a Swedish population - a potential link between the metabolic syndrome and hyperhomocysteinemia: the Skaraborg project. Metabolism: Clinical and Experimental 2006 55 1007-1013.
28. Dicker-Brown A, Fonseca VA, Fink LM & Kern PA. The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase: studies in hepatocytes. Atherosclerosis 2001 158 297-301.
29. Pinkney JH, Stehouwer CD, Coppack SW & Yudkin JS. Endothelial dysfunction: cause of the insulin resistance syndrome. Diabetes 1997 46 S9-S13.
30. Christodoulakos GE, Lambrinoudaki IV, Rizos DA, Alexandrou A, Kountouris AV & Creatsas GC. Endogenous sex steroids and circulating homocysteine in healthy Greek postmenopausal women. Hormones 2006 5 35-41.
31. Lambrinoudaki IV, Christodoulakos GE, Rizos DA, Economou E, Argeitis J, Vlachou S, Creatsa M, Kouskouni E & Botsis D. Endogenous sex hormones and risk factors for atherosclerosis in healthy Greek postmenopausal women. European Journal of Endocrinology 2006 154 907-916.
32. Heikkinen AM, Niskanen L, Ryynanen M, Komulainen MH, Tuppuraine MT, Parviainen M & Saarikoski S. Is the response of serum lipids and lipoproteins to postmenopausal hormone replacement therapy modified by ApoE genotype? Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 402-407.
33. Singh CF & Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. American Journal of Human Genetics 1985 37 268-285.
34. Zofková I, Zajicková K, Hill M & Horínek A. Apolipoprotein E gene determines serum testosterone and dehydroepiandrosterone levels in postmenopausal women. European Journal of Endocrinology 2002 147 503-506.
35. Barrett-Connor E & Von Muhlen D. The association of apolipoprotein E with sex hormones in a population-based sample of postmenopausal Caucasian women. European Journal of Endocrinology 2003 148 487-488.