Androgenicity and Obesity Are Independently Associated with Insulin Sensitivity in Postmenopausal Women

Metabolism: Clinical and Experimental

Volumn 53, Issue 4, 2004, Pages 507-512

  Lee, Cathy C ^a   Kasa Vubu, Josephine Z ^b   Supiano, Mark A ^b  

^a VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; GLUCOSE; INSULIN; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ANDROGEN METABOLISM; ANDROGENIZATION; ARTICLE; BODY COMPOSITION; BODY MASS; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL;

EID: 1842479594     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2003.10.018     Document Type: Article

References (39)

1. Supiano MA, Hogikyan RV, Morrow LA, et al: Aging and insulin sensitivity: Role of blood pressure and sympathetic nervous system activity. J Gerontol 48:M237-M243, 1993
2. Poehlman ET, Toth MJ, Gardner AW: Changes in energy bablance and body composition at menopause: A controlled longitudinal study. Ann Intern Med 123:673-675, 1995
3. Evans DJ, Hoffmann RG, Kalkhoff RK, et al: Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 57:304-310, 1983
4. Haffner SM, Katz MS, Stern MP, et al: The relationship of sex hormones to hyperinsulinemia and hyperglycemia. Metabolism 37: 683-688, 1988
5. Linstedt G, Lundberg P-A, Lapidus L, et al: Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM, 12-yr follow-up of population study of women in Gothenburg, Sweden. Diabetes 40:123-128, 1991
6. Haffner SM, Valdez RA, Morales PA, et al: Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men. J Clin Endocrinol Metab 77:56-60, 1993
7. Geola FL, Frumar AM, Tataryn IV, et al: Biological effects of various doses of conjugated equine estrogens in postmenopausal women. J Clin Endocrinol Metab 51:620-625, 1980
8. Lindheim SR, Buchanan TA, Duffy DM, et al: Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gynecol Investig 1:150-144, 1994
9. Haffner SM, Katz MS, Dunn JF: Increased upper body and overall adipostiy associated with decreased sex hormone binding globulin in postmenopausal women. Int J Obes 15:471-478, 1991
10. Kaye SA, Folsom AR, Soler JT, et al: Associations of body mass and fat distribution with sex hormone concentrations in postmenopausal women. Int J Epidemiol 20:151-156, 1991
11. Krotkiewski M, Seidell JC, Björntorp P: Glucose tolerance and hyperinsulinaemia in obese women: role of adipose tissue distribution, muscle fibre characterisstics and androgens. J Intern Med 228:385-392, 1990
12. Tchernof A, Toth MJ, Poehlman ET: Sex hormone-binding globulin levels in middle aged premenopausal women: Associations with visceral obesity and metabolic profile. Diabetes Care 22:1875-1881, 1999
13. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 21:S5-S19, 1998 (suppl 1)
14. Wilke TJ, Utley DJ: Total testosterone, free-androgen index, calculated free testosterone, and free testosterone by analog RIA compared in hirsute women and in otherwise-normal women with altered sex-hormone-binding-globulin. Clin Chem 33:1372-1375, 1987
15. Bergman R: Toward physiological understanding of glucose tolerance: Minimal model approach. Diabetes 38:1512-1527, 1989
16. Yang Y, Youn J, Bergman R: Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol 253:E595-E602, 1987
17. Mazess R, Barden H, Bisek J, et al: Dual-energy x-ray absorptiometry for total-body and regional one-mineral and soft-tissue composition. Am J Clin Nutr 51:1106-1112, 1990
18. Oh J-Y, Barrett-Connor E, Wedick NM, et al: Endogenous sex hormones and the development of type 2 diabetes in older men and women: The Rancho Bernardo study. Diabetes Care 25:55-60, 2002
19. Haffner SM, Katz MS, Stern MP, et al: Relationship of sex hormone binding globulin to overall adiposity and body fat distribution in a biethnic population. Int J Obes 13:1-9, 1989
20. Svendsen OL, Hassager C, Christiansen C: Relationships and independence of body composition, sex hormones, fat dsitribution and other cardiovascular risk factors in overweight postmenopausal women. Int J Obes Relat Metab Disord 17:459-463, 1993
21. Abate N, Haffner SM, Garg A, et al: Sex steroid hormones, upper body obesity, and insulin resistance. J Clin Endocrinol Metab 87:4522-4527, 2002
22. McKerns KW, Coulomb B, Kaleita E, et al: Some effects of in vivo administered estrogens on glucose metabolism and adrenal cortical secretion in vitro. Endocrinology 63:709-722, 1958
23. Costrini NV, Kalkhoff RK: Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion. J Clin Invest 50:992-999, 1971
24. Bailey CJ, Ahmed-Sorour H: Role of ovarian hormones in the long-term control of glucose homeostasis. Diabetologia 19:475-481, 1980
25. Barrett-Connor E, Laakso M: Ischemic heart disease risk in postmenopausal women. Effects of estrogen use on glucose and insulin levels. Arteriosclerosis 10:531-534, 1990
26. Hammond CB, Jelovsek FR, Lee KL, et al: Effects of long-term estrogen replacement therapy. Am J Obstet Gynecol 133:525-536, 1979
27. Notelovitz M, Johnston M, Smith S, et al: Metabolic and hormonal effects of 25-mg and 50-mg 17β-estradiol implants in surgically menopausal women. Obstet Gynecol 70:749-754, 1987
28. Lee CC, Kasa-Vubu JZ, Supiano MA: Differential effects of raloxifene and estrogen on insulin sensitivity in postmenopausal women. J Am Geriatr Soc 51:683-688, 2003
29. Spellacy WN, Buhi WC, Birk SA: The effect of estrogens on carbohydrate metabolism: Glucose, insulin, and growth hormone studies on one hundred and seventy-one women ingesting premarin, mestranol, and ethinyl estradiol for six months. Am J Obstet Gynecol 114:378-392, 1972
30. Cagnacci A, Soldani R, Carriero PL, et al: Effects of low doses of transdermal 17β-estradiol on carbohydrate metabolism in postmenopausal women. J Clin Endocrinol Metab 74:1396-1400, 1992
31. Ajabor LN, Tsai CC, Vela P, et al: Effect of exogenous estrogen on carbohydrate metabolism in postmenopausal women. Am J Obstet Gynecol 113:383-387, 1972
32. Godsland IF, Gangar K, Walton C, et al: Insulin resistance, secretion, and elimination in postmenopausal women receiving oral or transdermal hormone replacement therapy. Metabolism 42:846-853, 1993
33. Lindheim SR, Presser SC, Ditkoff EC, et al: A possible bimodal effect of estrogen on insulin sensitivity in postmenopausal women and the attenuating effect of added progestin. Fertil Steril 60:664-667, 1993
34. Epseland MA, Stefanick ML, Dritz-Silverstein D, et al: Effect of postmenopausal hormone therapy on body weight and waist and hip girths. J Clin Endocrinol Metab 82:1549-1556, 1997
35. Haarbo J, Marslew U, Gotfredsen A, et al: Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 40:1323-1326, 1991
36. Plymate SR, Matej LA, Jones RE, et al: Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab 67:460-464, 1988
37. Nestler JE, Powers LP, Matt DW, et al: A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab 72:83-89, 1991
38. Nestler JE, Clore JN, Strauss JF III, et al: The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. J Clin Endocrinol Metab 64:180-184, 1987
39. Ley CJ, Lees B, Stevenson JC: Sex- and menopuase-associated changes in body-fat distribution. Am J Clin Nutr 55:950-954, 1992