The 4G/4G PAI-1 genotype is associated with elevated plasma PAI-1 levels regardless of variables of the metabolic syndrome and smoking status. A population-based study in Spanish population

Diabetes, Obesity and Metabolism

Volumn 9, Issue 1, 2007, Pages 134-135

  Martinez Calatrava M J ^a   Martinez Larrad M T ^a   Zabena, C ^a   Gonzalez Sanchez J L ^a   Fernandez Perez C ^a   Serrano Rios M ^a,b  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b Cea Bermúdez Primary Health Care Centre   (Spain)

Author keywords

PAI 1 gene polymorphism; Plasminogen activator inhibitor; Smoking status

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; POPULATION RESEARCH; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SMOKING; SPAIN; STATISTICAL MODEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

EID: 33845545483     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2006.00584.x     Document Type: Article

References (8)

1. Sartori MT, Vettor R, De Pergols G et al. Role of the 4G/5G polymorphism of PAI-1 gene promoter on PAI-1 levels in obese patients. Influence of fat distribution and insulin-resistance. Thromb Haemost 2001; 86: 1161-1169.
2. Burzotta F, Di Castelnuovo A, Amore C et al. 4G/5G promoter PAI-1 gene polymorphism is associatted with plasmatic activity in italians: A model of gene-environmet interaction. Thromb Haemost 1998; 79: 354-358.
3. Lee KW, Lip GY. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: A systematic review. Arch Intern Med 2003; 163: 2368-2392.
4. Martínez-Larrad MT, Fernández-Pérez C, González-Sánchez JL et al. Prevalence of the metabolic syndrome (ATP-III criteria). Population-based study of rural and urban areas in the Spanish province of Segovia. Med Clin (Barc) 2005; 125: 481-486.
5. Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet 2005; 366: 1059-1062.
6. Margaglione M, Cappucci G, d'Addedda M. PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: Relation to environmental and genetic determinants. Arterioscler Thromb Vasc Biol 1998; 18: 562-567.
7. Eliasson M, Asplund K, Ervin PE, Lundblad D. Relationship of cigarette smoking and snuff dipping to plasma fibrinogen, fibrinolytic variables and serum insulin: The Northern Sweden MONICA Study. Atherosclerosis 1995; 113: 41-53.
8. Jastrzebska M, Goracy I, Naruszewicz M. Relationships between fibrinogen, plasminogen activator inhibitor-1, and their gene polymorphisms in current smokers with essential hypertension. Thromb Res 2003; 110: 339-344.