The history and future prospective of haplo-identical stem cell transplantation

Cytotherapy

Volumn 10, Issue 5, 2008, Pages 443-451

  Handgretinger, Rupert ^a   Lang, P ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Alloreactivity; Haplo identical transplantation; Immune reconstitution; T cell depletion

Indexed keywords

ALEMTUZUMAB; CD19 ANTIBODY; CD20 ANTIBODY; CD3 ANTIBODY; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CYCLOPHOSPHAMIDE; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; HLA ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 7; KERATINOCYTE GROWTH FACTOR; MELPHALAN; OKT 3; THIOTEPA; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOPTIVE TRANSFER; ALLOIMMUNITY; CD34 SELECTION; CHRONIC GRAFT VERSUS HOST DISEASE; CYTOMEGALOVIRUS INFECTION; DONOR LYMPHOCYTE INFUSION; GRAFT FAILURE; GRAFT REJECTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE DEFICIENCY; LEUKEMIA; LYMPHOPROLIFERATIVE DISEASE; MORTALITY; MYELOABLATIVE CONDITIONING; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRIMARY PREVENTION; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; REVIEW; RISK BENEFIT ANALYSIS; STEM CELL MOBILIZATION; STEM CELL TRANSPLANTATION; T CELL DEPLETION; THERAPY EFFECT; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME; WHOLE BODY RADIATION;

EID: 53249086108     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1080/14653240802251507     Document Type: Review

References (70)

1. Beatty, PG, Mori, M. and Milford, E. (1995) Impact of racial genetic polymorphism on the probability of finding an HLA-matched donor. Transplantation, 60, pp. 778-783.
2. Heemskerk, MB, van Walraven, SM Cornelissen, JJ et al. (2005) How to improve the search for an unrelated haematopoietic stem cell donor. Faster is better than more! Bone Marrow Transplant, 35, pp. 645-652.
3. Tiercy, JM, Nicoloso, G. Passweg, J. et al. (2007) The probability of identifying a 10/10 HLA allele-matched unrelated donor is highly predictable. Bone Marrow Transplant, 40, pp. 515-522.
4. Powles, RL, Morgenstern, GR Kay, HE et al. (1983) Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia. Lancet, 1, pp. 612-615.
5. Beatty, PG, Clift, RA Mickelson, EM et al. (1985) Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med, 313, pp. 765-771.
6. Szydlo, R., Goldman, JM Klein, JP et al. (1997) Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. J Clin Oncol, 15, pp. 1767-1777.
7. Friedrich, W., Goldmann, SF Vetter, U. et al. (1984) Immunoreconstitution in severe combined immunodeficiency after transplantation of HLA-haploidentical, T-cell-depleted bone marrow. Lancet, 1, pp. 761-764.
8. Mehta, J., Singhal, S. Gee, AP et al. (2004) Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia: single-center experience of 201 patients. Bone Marrow Transplant, 33, pp. 389-396.
9. Henslee-Downey, PJ, Abhyankar, SH Parrish, RS et al. (1997) Use of partially mismatched related donors extends access to allogeneic marrow transplant. Blood, 89, pp. 3864-3872.
10. Aversa, F., Martelli, MM and Reisner, Y. (1997) Use of stem cells from mismatched related donors. Curr Opin Hematol, 4, pp. 419-422.
11. Bachar-Lustig, E., Rachamim, N. Li, HW et al. (1995) Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Nat Med, 1, pp. 1268-1273.
12. Rachamim, N., Gan, J. Segall, H. et al. (1998) Tolerance induction by 'megadose' hematopoietic transplants: Donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture. Transplantation, 65, pp. 1386-1393.
13. Gur, H., Krauthgamer, R. Berrebi, A. et al. (2002) Tolerance induction by megadose hematopoietic progenitor cells: Expansion of veto cells by short-term culture of purified human CD34(+) cells. Blood, 99, pp. 4174-4181.
14. Aversa, F., Tabilio, A. Terenzi, A. et al. (1994) Successful engraftment of T-cell-depleted haploidentical 'three-loci' incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood, 84, pp. 3948-3955.
15. Aversa, F., Tabilio, A. Velardi, A. et al. (1998) Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med, 339, pp. 1186-1193.
16. Handgretinger, R., Lang, P. Schumm, M. et al. (1998) Isolation and transplantation of autologous peripheral CD34+ progenitor cells highly purified by magnetic-activated cell sorting. Bone Marrow Transplant, 21, pp. 987-993.
17. Schumm, M., Lang, P. Taylor, G. et al. (1999) Isolation of highly purified autologous and allogeneic peripheral CD34+ cells using the CliniMACS device. J Hematother, 8, pp. 209-218.
18. Handgretinger, R., Klingebiel, T. Lang, P. et al. (2001) Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children. Bone Marrow Transplant, 27, pp. 777-783.
19. Aversa, F., Terenzi, A. Tabilio, A. et al. (2005) Full haplotype-mismatched hematopoietic stem-cell transplantation: A phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol, 23, pp. 3447-3454.
20. Walker, I., Shehata, N. Cantin, G. et al. (2004) Canadian multicenter pilot trial of haploidentical donor transplantation. Blood Cells Mol Dis, 33, pp. 222-226.
21. Redei, I., Langston, AA Lonial, S. et al. (2002) Rapid hematopoietic engraftment following fractionated TBI conditioning and transplantation with CD34(+) enriched hematopoietic progenitor cells from partially mismatched related donors. Bone Marrow Transplant, 30, pp. 335-340.
22. Peters, C., Matthes-Martin, S. Fritsch, G. et al. (1999) Transplantation of highly purified peripheral blood CD34+ cells from HLA-mismatched parental donors in 14 children: Evaluation of early monitoring of engraftment. Leukemia, 13, pp. 2070-2078.
23. Yamasaki, S., Ohno, Y. Taniguchi, S. et al. (2004) Allogeneic peripheral blood stem cell transplantation from two- or three-loci-mismatched related donors in adult Japanese patients with high-risk hematologic malignancies. Bone Marrow Transplant, 33, pp. 279-289.
24. Kim, HJ, Min, WS Kim, YJ et al. (2005) Haplotype mismatched transplantation using high doses of peripheral blood CD34+ cells together with stratified conditioning regimens for high-risk adult acute myeloid leukemia patients: A pilot study in a single Korean institution. Bone Marrow Transplant, 35, pp. 959-964.
25. Ruggeri, L., Mancusi, A. Burchielli, E. et al. (2006) Natural killer cell recognition of missing self and haploidentical hematopoietic transplantation. Semin Cancer Biol, 16, pp. 404-411.
26. Velardi, A., Ruggeri, L. and Moretta, L. (2002) NK cells: A lesson from mismatched hematopoietic transplantation. Trends Immunol, 23, pp. 438-444.
27. Farag, SS, Fehniger, TA Ruggeri, L. et al. (2002) Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect. Blood, 100, pp. 1935-1947.
28. Ruggeri, L., Mancusi, A. Capanni, M. et al. (2007) Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: Challenging its predictive value. Blood, 110, pp. 433-440.
29. Leung, W., Iyengar, R. Turner, V. et al. (2004) Determinants of antileukemia effects of allogeneic NK cells. J Immunol, 172, pp. 644-650.
30. Ruggeri, L., Capanni, M. Urbani, E. et al. (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science, 295, pp. 2097-2100.
31. Gordon, PR, Leimig, T. Mueller, I. et al. (2002) A large-scale method for T cell depletion: Towards graft engineering of mobilized peripheral blood stem cells. Bone Marrow Transplant, 30, pp. 69-74.
32. Barfield, RC, Otto, M. Houston, J. et al. (2004) A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. Cytotherapy, 6, pp. 1-6.
33. Hale, GA, Kasow, KA Gan, K. et al. (2005) Haploidentical stem cell transplantation with CD3 depleted mobilized peripheral blood stem cell grafts for children with hematologic malignancies. ASH Annu Meet Abstr, 106, p. 2910.
34. Hale, GA, Kasow, KA Madden, R. et al. (2006) Mismatched family member donor transplantation for patients with refractory hematologic malignancies: Long-term followup of a prospective clinical trial. ASH Annu Meet Abstr, 108, p. 3137.
35. Chen, X., Hale, GA Barfield, R. et al. (2006) Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. Br J Haematol, 135, pp. 524-532.
36. Handgretinger, R., Chen, X. Pfeiffer, M. et al. (2007) Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation. Ann NY Acad Sci, 1106, pp. 279-289.
37. Bethge, WA, Faul, C. Bornhauser, M. et al. (2008) Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: An update. Blood Cell Mol Dis, 40, pp. 13-19.
38. Guinan, EC, Boussiotis, VA Neuberg, D. et al. (1999) Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med, 340, pp. 1704-1714.
39. Rizzieri, DA, Koh, LP Long, GD et al. (2007) Partially matched, nonmyeloablative allogeneic transplantation: Clinical outcomes and immune reconstitution. J Clin Oncol, 25, pp. 690-697.
40. Huang, XJ, Liu, DH Liu, KY et al. (2006) Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant, 38, pp. 291-297.
41. Ogawa, H., Ikegame, K. Yoshihara, S. et al. (2006) Unmanipulated HLA 2-3 antigen-mismatched (haploidentical) stem cell transplantation using nonmyeloablative conditioning. Biol Blood Marrow Transplant, 12, pp. 1073-1084.
42. O'Donnell, PV, Luznik, L. Jones, RJ et al. (2002) Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide. Biol Blood Marrow Transplant, 8, pp. 377-386.
43. Kolb, HJ, Guenther, W. Gyurkocza, B. et al. (2003) Tolerance and chimerism. Transplantation, 75, pp. 26-31.
44. Hauer, J., Tosi, S. Schuster, FR et al. (2008) Graft versus leukemia effect after haploidentical HSCT in a MLL-negative infant AML with HLXB9/ ETV6 rearrangement. Pediatr Blood Cancer, 50, pp. 921-923.
45. van Rood, JJ, Loberiza Jr, FR Zhang, MJ et al. (2002) Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling. Blood, 99, pp. 1572-1577.
46. Obama, K., Utsunomiya, A., Takatsuka, Y. and Takemoto, Y. (2004) Reduced-intensity non-T-cell depleted HLA-haploidentical stem cell transplantation for older patients based on the concept of feto-maternal tolerance. Bone Marrow Transplant, 34, pp. 897-899.
47. Ichinohe, T., Teshima, T. Matsuoka, K. et al. (2005) Fetal-maternal microchimerism: Impact on hematopoietic stem cell transplantation. Curr Opin Immunol, 17, pp. 546-552.
48. Cashen, AF, Lazarus, HM and Devine, SM. (2007) Mobilizing stem cells from normal donors: Is it possible to improve upon G-CSF?. Bone Marrow Transplant, 39, pp. 577-588.
49. Leung, W., Iyengar, R. Triplett, B. et al. (2005) Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. J Immunol, 174, pp. 6540-6545.
50. Stern, M., Ruggeri, L. Mancusi, A. et al. (2008) Survival after T-cell depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood
51. Kolb, HJ, Bigalke, I. Tischer, J. et al. (2005) Risk factors of HLA-haploidentical transplantation using the combination of unmodified marrow and CD6-depleted G-CSF mobilized blood cells. ASH Annu Meet Abstr, 106, p. 2907.
52. Chaleff, S., Otto, M. Barfield, RC et al. (2007) A large-scale method for the selective depletion of alpha/beta T lymphocytes from PBSC for allogeneic transplantation. Cytotherapy, 9, pp. 746-754.
53. Meeh, PF, King, M. O'Brien, RL et al. (2006) Characterization of the gamma/delta T cell response to acute leukemia. Cancer Immunol Immunother, 55, pp. 1072-1080.
54. Godder, KT, Henslee-Downey, PJ Mehta, J. et al. (2007) Long term disease-free survival in acute leukemia patients recovering with increased gamma/delta T cells after partially mismatched related donor bone marrow transplantation. Bone Marrow Transplant, 39, pp. 751-757.
55. Chen, X., Handgretinger, R. and Hale, GA. (2008) Molecular monitoring of immune reconstitution after haploidentical stem cell transplantation. Curr Stem Cell Res Ther, 3, pp. 75-78.
56. Volpi, I., Perruccio, K. Tosti, A. et al. (2001) Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype-mismatched hematopoietic transplants. Blood, 97, pp. 2514-2521.
57. Chen, X., Barfield, R. Benaim, E. et al. (2005) Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood, 105, pp. 886-893.
58. Wils, EJ and Cornelissen, JJ. (2005) Thymopoiesis following allogeneic stem cell transplantation: New possibilities for improvement. Blood Rev, 19, pp. 89-98.
59. Amrolia, PJ, Muccioli-Casadei, G. Huls, H. et al. (2006) Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation. Blood, 108, pp. 1797-1808.
60. Feuchtinger, T., Richard, C. Joachim, S. et al. (2008) Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation. J Immunother, 31, pp. 199-206.
61. Einsele, H., Kapp, M. and Grigoleit, GU. (2008) CMV-specific T cell therapy. Blood Cells Mol Dis, 40, pp. 71-75.
62. Beck, O., Topp, MS Koehl, U. et al. (2006) Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus. Blood, 107, pp. 2562-2569.
63. Perruccio, K., Tosti, A. Burchielli, E. et al. (2005) Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood, 106, pp. 4397-4406.
64. Bader, P., Hancock, J. Kreyenberg, H. et al. (2002) Minimal residual disease (MRD) status prior to allogeneic stem cell transplantation is a powerful predictor for post-transplant outcome in children with ALL. Leukemia, 16, pp. 1668-1672.
65. Klingebiel, T., Lang, P. Schumm, M. et al. (2005) Experiences with haploidentical stem cell transplantation in children with acute lymphoblastic leukemia. Pathol Biol (Paris), 53, pp. 159-161.
66. Terme, M., Ullrich, E. Delahaye, NF et al. (2008) Natural killer cell-directed therapies: Moving from unexpected results to successful strategies. Nat Immunol, 9, pp. 486-494.
67. Huang, XJ, Wang, Y. Liu, DH et al. (2008) Modified donor lymphocyte infusion (DLI) for the prophylaxis of leukemia relapse after hematopoietic stem cell transplantation in patients with advanced leukemia: Feasibility and safety study. J Clin Immunol
68. Sprangers, B., Van, WB Fevery, S. et al. (2007) Experimental and clinical approaches for optimization of the graft-versus-leukemia effect. Nat Clin Pract Oncol, 4, pp. 404-414.
69. Lang, P., Barbin, K. Feuchtinger, T. et al. (2004) Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts. Blood, 103, pp. 3982-3985.
70. Schumm, M., Feuchtinger, T. Pfeiffer, M. et al. (2007) Flow cytometry with anti HLA-antibodies: A simple but highly sensitive method for monitoring chimerism and minimal residual disease after HLA-mismatched stem cell transplantation. Bone Marrow Transplant, 39, pp. 767-773.