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Ash RC, Horowitz MM, Gale RP, van Bekkum DW, Casper JT, Gordon-Smith EC, Henslee-Downey PJ, Kolb HJ, Lowenberg B, Masaoka T, et al.: Bone marrow transplantation from related donors other than HLA-identical siblings: effect of T-cell depletion. Bone Marrow Transplant 1991, 7:443-452.
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Reisner Y, Kapoor N, Kirkpatrick D, Pollack MS, Cunningham-Rundles S, Dupont B, Hodes MZ, Good RA, O'Reilly RJ: Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow fractionated by soybean agglutinin and sheep red blood cells. Blood 1983, 61:341-348. This paper confirms the role of an extensive T-cell depletion in preventing severe acute and chronic GVHD in patients with SCID receiving a bone marrow transplant from a full-haplotype mismatched related donor.
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Reisner Y, Kirkpatrick D, Dupont B, Kapoor NK, Pollack MS, Good RA, O'Reilly RJ: Transplantation for acute leukaemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells. Lancet 1981, 2:327-331.
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Terenzi A, Aversa F, Albi N, Galandrini R, Dembech C, Velardi A, Martelli MF: Residual clonable host cell detection for predicting engraftment of T-cell depleted BMTs. Bone Marrow Transplant 1993, 11:357-361.
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Reisner Y, Martelli MF: Bone marrow transplantation across HLA barriers by increasing the number of transplanted cells, Immunol Today 1995, 16:437-440. The authors discuss how the problem of graft rejection in the mismatched setting may be overcome by intensification of the conditioning protocol in conjunction with a major increase in the dose of transplanted stem cells.
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Abrogation of bone marrow allograft resistance in mice by increased total body irradiation correlates with eradication of host clonable T cells and alloreactive cytotoxic precursors
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Schwartz E, Lapidot T, Dalia G, Singer T, Reisner Y: Abrogation of bone marrow allograft resistance in mice by increased total body irradiation correlates with eradication of host clonable T cells and alloreactive cytotoxic precursors. J Immunol 1987, 138:460-465.
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Lapidot T, Singer TS, Salomon O, Terenzi A, Schwartz E, Reisner Y: Booster irradiation to the spleen following total body irradiation: a new immunosuppressive approach for allogeneic bone marrow transplantation. J Immunol 1988, 141:2619-2624.
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Lapidot T, Terenzi A, Singer TS, Salomon O, Reisner Y: Enhancement by dimethyl myleran of donor type chimerism in murine recipients of bone marrow allografts. Blood 1989, 73:2025-2032.
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Terenzi A, Lubin I, Lapidot T, Salomon O, Faktorowich Y, Rabi I, Martelli MF, Reisner Y: Enhancement of T-cell depleted bone marrow allografts in mice by thiotepa. Transplantation 1990, 50:717-720.
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Bachar-Lustig E, Rachamim N, Hong-Wei Li, Lan F, Reisner Y: Megadose of T-cell depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Nature Med 1995, 12:1268-1273. This paper further demonstrated in an experimental mouse model that escalation of bone marrow doses by four- to fivefold led to full donor-type chimerism even in sublethally irradiated animals.
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Soiffer RJ, Mauch P, Tarbell NJ, Anderson KC, Freedman AS, Rabinowe SN, Takvorian T, Murrey CI, Coral F, Bosserman L, et al.: Total lymphoid irradiation to prevent graft rejection in recipients of HLA non-identical T-cell-depleted allogeneic marrow. Bone Marrow Transplant 1991, 7:23-33.
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Arthur C, Hows J, Jones L, Apperley J, Hale G, Waldmann H, Economou K, Gordon-Smith E, Goldman J: Marrow transplantation in absence of a HLA identical donor: the use of in vivo and ex vivo monoclonal antibodies. Bone Marrow Transplant 1987, 2:137.
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Friedrich W, Ebell W, Blutters-Sawatzki R, Wiesneth M, Goldmann SF, Kubarek B: In vivo use of monoclonal antibody for conditioning in T-cell depleted HLA-non-identical BMT. Bone Marrow Transplant 1987, 2:145.
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Aversa F, Tabilio A, Terenzi A, Velardi A, Falzetti F, Giannoni C, Jacucci R, Zei T, Martelli MP, Gambelunghe C, et al.: Successful engraftment of T-cell depleted haploidentical "three loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow Inoculum. Blood 1994, 84:3948-3955. This was the first clinical study confirming that in humans, as in mice, the stem cell dose, in combination with a highly immunosuppressive and myeloablative conditioning, plays a crucial role in overcoming the HLA-histocompatibility barriers.
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Blood
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Gambelunghe, C.10
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A shorter procedure for preparation of E-rosette depleted bone marrow for transplantation
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Reisner Y, Friederich W, Fabian I: A shorter procedure for preparation of E-rosette depleted bone marrow for transplantation. Transplantation 1986, 42:312-316.
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Efficacy of fludarabine as immunosuppressor for bone marrow transplantation conditioning
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Terenzi A, Aversa F, Perruccio K, Aristei C, Chionne F, Latini P, Martelli MF: Efficacy of fludarabine as immunosuppressor for bone marrow transplantation conditioning [abstract]. Blood 1996, 88(suppl 1): 2373.
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Martelli MF, Aversa F, Velardi A, Cunningham I, Tabilio A, Terenzi A, Falzetti F, Felicini R, Ruggeri L, Albi N, et al.: New tools for crossing the HLA barrier: fludarabine and megadose stem cell transplants [abstract]. Blood 1996, 88(suppl 1):1924.
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Martelli, M.F.1
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Albi N, Ruggeri L, Aversa F, Merigiola C, Tosti A, Tognellini R, Grossi CE, Martelli MF, Velardi A: Natural killer (NK)-cell function and antileukemic activity of a large population of CD3+/CD8+ T cells expressing NK receptors for major histocompatibility complex class I after "three loci" HLA-incompatible bone marrow transplantation. Blood 1996, 87:3993-4000. The authors demonstrated that in mismatched transplant recipients, in addition to conventional natural killer cells, two potential antitumor effectors were detected: KIR cytotoxic T cells and donor-versus-recipient alloreactive natural killer cells. They can provide a selective graft-versus-leukemia effect in absence of graft-versus-host reaction.
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Blood
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Albi, N.1
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Grossi, C.E.7
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