Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients

Blood

Volumn 105, Issue 2, 2005, Pages 886-893

  Chen, Xiaohua ^a   Barfield, Raymond ^b   Benaim, Ely ^b   Leung, Wing ^b   Knowles, James ^b   Lawrence, Dawn ^b   Otto, Mario ^b   Shurtleff, Sheila A ^b   Neale, Geoffrey A M ^b   Behm, Frederick G ^b   Turner, Victoria ^b   Handgretinger, Rupert ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; ETOPOSIDE; FLUDARABINE; GEMTUZUMAB OZOGAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; IMATINIB; IMMUNOGLOBULIN; OKT 3; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; THYMOCYTE ANTIBODY;

ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; INCIDENCE; INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECIPIENT; STEM CELL; T LYMPHOCYTE; THYMUS;

EID: 19944428980     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-04-1405     Document Type: Article

References (22)

1. Haynes BF, Marken ML, Sempowski GD, et al. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Ann Rev Immunol. 2000;18:529-560.
2. Weinberg K, Blazar BR, Wagner JE, et al. Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation. Blood. 2001;97:1458-1466.
3. Talvensaari K, Clave E, Douay C, et al. A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation. Blood. 2002;99:1458-1464.
4. Kimmig S, Przybylski GK, Schmidt CA, et al. Two subsets of naïve T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med. 2002;195:789-794.
5. Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690-695.
6. Gorski J, Yassai M, Zhu X, et al. CirculatingT cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J Immunol. 1994;152:5109-5119.
7. Pannetier C, Cochet M, Darche S, et al. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci U S A. 1993;90:4319-4323.
8. Jorgensen JL, Esser U, Fazekas de St Groth B, et al. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature. 1992;355:224-230.
9. Douek DC, Vescio RA, Betts MR, et al. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet. 2000;355:1875-1881.
10. Dumont-Girard F, Roux E, van Lier RA, et al. Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants. Blood. 1998;92:4464-4471.
11. Lewin SR, Heller G, Zhang L, et al. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood. 2002;100:2235-2242.
12. Hochberg EP, Chillemi AC, Wu CJ, et al. Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults. Blood. 2001;98:1116-1121.
13. Talvensaari K, Garnier F, Busson M. Pretransplant thymic function could have a predictive value for the incidence of graft vs host disease and general outcome after allogeneic bone marrow transplantation [abstract]. Blood. 2001;98:396a.
14. Svaldi M, Lanthaler AJ, Dugas M, et al. T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients. Br J Haematol. 2003;122:795-801.
15. + progenitor cells from HLA-mismatched parental donors in children. Bone Marrow Transplant. 2001;27:777-783.
16. Gordon PR, Leimig T, Mueller I, et al. A large-scale method for T cell depletion: towards graft engineering of mobilized peripheral blood stem cells. Bone Marrow Transplant. 2002;30:69-74.
17. Hazenberg MD, Otto SA, Cohen Stuart JWT, et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naïve T cell population in HIV-1 infection. Nat Med. 2000;6:1036-1042.
18. Gorski J, Piatek T, Yassai M, et al. Improvements in repertoire analysis by CDR3 size spectratyping bifamily PCR. Ann N Y Acad Sci. 1995;756:99-102.
19. Wu CJ, Chillemi A, Alyea EP, et al. Reconstitution of T-cell receptor repertoire diversity following T cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism. Blood. 2000;95:352-359.
20. Kreyenberg H, Hölle W, Möhrle S, et al. Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Tuebingen experience. Leukemia. 2003;17:237-240.
21. Steffens CM, Al-Harthi L, Shott S, et al. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naïve phenotypes. Clin Immunol. 2000;97:95-101.
22. Imamura M, Tsutsumi Y, Miura Y, Toubai T, et al. Immune reconstitution and tolerance after allogeneic hematopoietic stem cell transplantation. Hematology. 2003;8:19-26.