Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes

Cell Stress and Chaperones

Volumn 13, Issue 3, 2008, Pages 365-373

  Luo, Xinjing ^a,b   Zuo, Xiaoxia ^c   Zhang, Bing ^a   Song, Lan ^a   Wei, Xing ^a   Zhou, Yaou ^c   Xiao, Xianzhong ^a  

^a Central South University   (China)

^b TAIZHOU UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cytokines; Extracellular Hsp70; Rheumatoid arthritis; Toll like receptors

Indexed keywords

HEAT SHOCK PROTEIN 70; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TLR4 PROTEIN, HUMAN;

ARTICLE; CELL CULTURE; CELL STRESS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HEAT SHOCK; HEAT STRESS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; THERMAL EXPOSURE; UPREGULATION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; HEAT; IMMUNOLOGY; METABOLISM; MOUSE; PATHOLOGY; SYNOVIUM;

ANIMALS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; FIBROBLASTS; HEAT; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-10; MICE; SYNOVIAL MEMBRANE; TOLL-LIKE RECEPTOR 4;

EID: 53149106311     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-008-0036-2     Document Type: Article

References (44)

1. Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2 (8):675-680 (Pubitemid 32747155)
2. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315-324 (Pubitemid 18091653)
3. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK (2000) HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6(4):435-442 (Pubitemid 30208161)
4. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277(17):15028-15034
5. Aupperle KR, Bennett BL, Boyle DL, Tak PP, Manning AM, Firestein GS (1999) NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes. J Immunol 163(1):427-433 (Pubitemid 29295870)
6. Bausinger H, Lipsker D, Ziylan U, Manie S, Briand JP, Cazenave JP, Muller S, Haeuw JF, Ravanat C, de la Salle H et al (2002) Endotoxin-free heat-shock protein 70 fails to induce APC activation. Eur J Immunol 32(12):3708-3713 (Pubitemid 36032655)
7. Broquet AH, Thomas G, Masliah J, Trugnan G, Bachelet M (2003) Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release. J Biol Chem 278(24):21601-21606 (Pubitemid 36792559)
8. Cho ML, Kim WU, Min SY, Min DJ, Min JK, Lee SH, Park SH, Cho CS, Kim HY (2002) Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor α production by rheumatoid synoviocytes. Arthritis Rheum 46(1):42-51 (Pubitemid 34121649)
9. Corrigall VM, Bodman-Smith MD, Brunst M, Cornell H, Panayi GS (2004) Inhibition of antigen-presenting cell function and stimulation of human peripheral blood mononuclear cells to express an antiinflammatory cytokine profile by the stress protein BiP: relevance to the treatment of inflammatory arthritis. Arthritis Rheum 50(4):1164-1171 (Pubitemid 38480826)
10. De AK, Kodys KM, Yeh BS, Miller-Graziano C (2000) Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus. J Immunol 165(7):3951-3958 (Pubitemid 32057304)
11. Dybdahl B, Wahba A, Lien E, Flo TH, Waage A, Qureshi N, Sellevold OF, Espevik T, Sundan A (2002) Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4. Circulation 105(6):685-690 (Pubitemid 34157370)
12. Dybdahl B, Slordahl SA, Waage A, Kierulf P, Espevik T, Sundan A (2005) Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction. Heart 91(3):299-304 (Pubitemid 40299205)
13. Feldmann M, Maini RN (1999) The role of cytokines in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 38 (Suppl 2):3-7 (Pubitemid 29533264)
14. Fleshner M, Johnson JD (2005) Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function. Int J Hyperthermia 21(5):457-471 (Pubitemid 41102944)
15. Gao B, Tsan MF (2004) Induction of cytokines by heat shock proteins and endotoxin in murine macrophages. Biochem Biophys Res Commun 317(4):1149-1154 (Pubitemid 38496430)
16. Georganas C, Liu H, Perlman H, Hoffmann A, Thimmapaya B, Pope RM (2000) Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun. J Immunol 165(12):7199-7206 (Pubitemid 32001197)
17. Gutierrez-Canas I, Juarranz Y, Santiago B, Arranz A, Martinez C, Galindo M, Paya M, Gomariz RP, Pablos JL (2006) VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts. Rheumatology (Oxford) 45(5):527-532
18. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, Margulis B (2001) In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914(1-2):66-73
19. Hauet-Broere F, Wieten L, Guichelaar T, Berlo S, van der Zee R, Van Eden W (2006) Heat shock proteins induce T cell regulation of chronic inflammation. Ann Rheum Dis 65(Suppl 3):iii65-iii68
20. Isomaki P, Luukkainen R, Saario R, Toivanen P, Punnonen J (1996) Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum 39(3):386-395 (Pubitemid 26085214)
21. Johnson BJ, Le TT, Dobbin CA, Banovic T, Howard CB, Flores Fde M, Vanags D, Naylor DJ, Hill GR, Suhrbier A (2005) Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem 280(6):4037-4047 (Pubitemid 40288567)
22. Kiang JG, Tsokos GC (1998) Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 80(2):183-201 (Pubitemid 28498227)
23. Kim KW, Cho ML, Lee SH, Oh HJ, Kang CM, Ju JH, Min SY, Cho YG, Park SH, Kim HY (2007) Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol Lett 110(1):54-64 (Pubitemid 46695759)
24. Lancaster GI, Febbraio MA (2005) Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem 280(24):23349-23355 (Pubitemid 40853248)
25. Mambula SS, Calderwood SK (2006) Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes. J Immunol 177(11):7849-7857
26. Martin CA, Carsons SE, Kowalewski R, Bernstein D, Valentino M, Santiago-Schwarz F (2003) Aberrant extracellular and dendritic cell (DC) surface expression of heat shock protein (hsp) 70 in the rheumatoid joint: possible mechanisms of hsp/DC-mediated cross-priming. J Immunol 171(11):5736-5742 (Pubitemid 37467188)
27. Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1(2):135-145 (Pubitemid 33741967)
28. Min DJ, Cho ML, Lee SH, Min SY, Kim WU, Min JK, Park SH, Cho CS, Kim HY (2004) Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts. Arthritis Rheum 50(4):1146-1155 (Pubitemid 38480824)
29. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A (1998) The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187(12):2097-2101 (Pubitemid 28285580)
30. Nakahara H, Nishimoto N (2006) Anti-interleukin-6 receptor antibody therapy in rheumatic diseases. Endocr Metab Immune Disord Drug Targets 6(4):373-381
31. Panayi GS, Corrigall VM (2006) BiP regulates autoimmune inflammation and tissue damage. Autoimmun Rev 5(2):140-142 (Pubitemid 43129546)
32. Pierer M, Rethage J, Seibl R, Lauener R, Brentano F, Wagner U, Hantzschel H, Michel BA, Gay RE, Gay S et al (2004) Chemokine secretion of rheumatoid arthritis synovial fibroblasts stimulated by Toll-like receptor 2 ligands. J Immunol 172(2):1256-1265 (Pubitemid 38113789)
33. Quintana FJ, Cohen IR (2005) Heat shock proteins as endogenous adjuvants in sterile and septic inflammation. J Immunol 175(5):2777-2782 (Pubitemid 41170492)
34. Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, Joosten LA, van den Berg WB (2004) Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 50(12):3856-3865 (Pubitemid 39643932)
35. Sacre SM, Andreakos E, Kiriakidis S, Amjadi P, Lundberg A, Giddins G, Feldmann M, Brennan F, Foxwell BM (2007) The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am J Pathol 170(2):518-525 (Pubitemid 47339389)
36. Satoh M, Shimoda Y, Akatsu T, Ishikawa Y, Minami Y, Nakamura M (2006) Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction. Eur J Heart Fail 8(8):810-815
37. Schett G, Redlich K, Xu Q, Bizan P, Groger M, Tohidast-Akrad M, Kiener H, Smolen J, Steiner G (1998) Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest 102(2):302-311
38. Seibl R, Birchler T, Loeliger S, Hossle JP, Gay RE, Saurenmann T, Michel BA, Seger RA, Gay S, Lauener RP (2003) Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am J Pathol 162(4):1221-1227 (Pubitemid 36350666)
39. Svensson PA, Asea A, Englund MC, Bausero MA, Jernas M, Wiklund O, Ohlsson BG, Carlsson LM, Carlsson B (2006) Major role of HSP70 as a paracrine inducer of cytokine production in human oxidized LDL treated macrophages. Atherosclerosis 185(1):32-38 (Pubitemid 43117548)
40. Tanaka Y, Otsuka T, Hotokebuchi T, Miyahara H, Nakashima H, Kuga S, Nemoto Y, Niiro H, Niho Y (1996) Effect of IL-10 on collagen-induced arthritis in mice. Inflamm Res 45(6):283-288 (Pubitemid 26197549)
41. Tsan MF, Gao B (2004) Cytokine function of heat shock proteins. Am J Physiol Cell Physiol 286(4):C739-C744 (Pubitemid 38543800)
42. van Eden W, van der Zee R, Prakken B (2005) Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 5(4):318-330 (Pubitemid 40516157)
43. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maini RN, Feldmann M (1996) Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum 39(3):495-503 (Pubitemid 26085226)
44. Zanin-Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, Cohen IR, Lider O (2005) Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines. J Immunol 174(6):3227-3236 (Pubitemid 40354025)