In vitro effects of tea polyphenols on redox metabolism, oxidative stress, and apoptosis in PC12 cells

Annals of the New York Academy of Sciences

Volumn 1138, Issue , 2008, Pages 358-365

  Raza, Haider ^a   John, Annie ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Apoptosis; Black tea polyphenols; EGCG; GSH metabolism; Oxidative stress

Indexed keywords

BLACK TEA POLYPHENOL; CASPASE 3; CYTOCHROME C; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; LIPID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYPHENOL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GROWTH; CANCER INHIBITION; CARBONYLATION; CELL CULTURE; CELL ISOLATION; CELL STRAIN; CONFERENCE PAPER; CONTROLLED STUDY; DNA FRAGMENTATION; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME METABOLISM; GLUTATHIONE METABOLISM; IMMUNOBLOTTING; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NICK END LABELING; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; TEA; WESTERN BLOTTING;

ANIMALIA; CAMELLIA SINENSIS;

EID: 53149092910     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1414.037     Document Type: Conference Paper

References (29)

1. Rice-Evans, C.A. 1995. Plant polyphenols: free radical scavengers or chain-breaking antioxidants? Biochem. Soc. Sym. 61 : 103 116.
2. Yang, C.S., P. Maliakal & X. Meng. 2002. Inhibition of carcinogenesis by tea. Ann. Rev. Pharmacol. Toxicol. 42 : 25 54.
3. Ahmad, N., D.K. Feyes, A.L. Nieminen, et al. 1997. Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J. Natl. Cancer Inst. 89 : 1881 1886.
4. Wang, Z.Y., M.T. Huang, Y.R. Lou, et al. 1994. Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7, 12 dimethylbenz[a] anthracene-initiated SKH-1 mice. Cancer Res. 54 : 3428 3435.
5. Lee, M.-J., Z.Y. Wang, H. Li, et al. 1995. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol. Biomarkers Prev. 4 : 393 399.
6. Elbling, L., R.M. Weiss, O. Teufelhofer, et al. 2005. Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J. 19 : 807 829.
7. Bors, W., W. Heller, C. Michel & M. Saran. 1990. Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods Enzymol. 186 : 343 355.
8. Guo, Q., B. Zhao, M. Li, et al. 1996. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim. Biophys. Acta 1304 : 210 222.
9. Halliwell, B., J. Rafter & A. Jenner. 2005. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am. J. Clin. Nutr. 81 : 268S 276S.
10. Higdon, J.V. & B. Frei. 2003. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 43 : 89 143.
11. Isbrucker, R.A., J.A. Edwards, E. Wolz, et al. 2006. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies. Food Chem.Toxicol. 44 : 636 650.
12. Raza, H. & A. John. 2005. Green tea polyphenol epigallocatechin-3- gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol. Appl. Pharmacol. 207 : 212 220.
13. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 : 248 254.
14. Raza, H. & A. John. 2006. 4-Hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol. Appl. Pharmacol. 216 : 309 318.
15. Li, Y., H. Zhu, P. Kuppusamy, et al. 1998. Validation of lucigenin (bis-N-methylacrydium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J. Biol. Chem. 273 : 2015 2023.
16. Raza, H. & A. John. 2007. In vitro protection of reactive oxygen species-induced degradation of lipids, proteins and 2-deoxyribose by tea catechins. Food Chem. Toxicol. 45 : 1814 1820.
17. Reznick, A.Z. & L. Packer. 1994. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 233 : 357 363.
18. Whiteside, M.A., D.C. Heimburger & G.L. Johanning. 2004. Micronutrients and cancer therapy. Nutr. Rev. 62 : 142 147.
19. Fariss, M.W., C.B. Chan, M. Patel, et al. 2005. Role of mitochondria in toxic oxidative stress. Mol. Inter. 5 : 94 111.
20. Enns, G.M. 2003. The contribution of mitochondria to common disorders. Mol. Gen. Metab. 80 : 11 26.
21. Esterbauer, H., R.J. Schaur & H. Zollner. 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11 : 81 128.
22. Awasthi, Y.C., G.A. Ansari & S. Awasthi. 2005. Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol 401 : 379 407.
23. Nakashima, I., W. Liu, A.A. Akhand, et al. 2003. 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Mol. Aspects Med. 24 : 231 238.
24. Uchida, K., M. Shiraishi, Y. Naito, et al. 1999. Activation of stress signaling pathways by the end product of lipid peroxidation: 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J. Biol. Chem. 274 : 2234 2242.
25. West, J.D. & L.J. Marnett. 2005. Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. Chem. Res. Toxicol. 18 : 1642 1653.
26. Steffen, Y., T. Schewe & H. Sies. 2005. Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase. Biochem. Biophys. Res. Commun. 331 : 1277 1283.
27. Hagerman, A.E., R.T. Dean & M.J. Davies. 2003. Radical chemistry of epigallocatechin gallate and its relevance to protein damage. Arch. Biochem. Biophys. 414 : 115 120.
28. Stanner, S.A., J. Hughes, C.N. Kelly & J. Buttris. 2004. A review of the epidemiological evidence for the "antioxidant hypothesis". Pub. Hlth. Nut. 7 : 407 422.
29. Erba, D., P. Riso, A. Bordoni, et al. 2005. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J. Nut. Biochem. 16 : 144 149.