메뉴 건너뛰기




Volumn 45, Issue 10, 2007, Pages 1814-1820

In vitro protection of reactive oxygen species-induced degradation of lipids, proteins and 2-deoxyribose by tea catechins

Author keywords

GSH metabolism; Lipid peroxidation; Protein carbonylation; ROS; Tea catechins

Indexed keywords

2 DEOXYRIBOSE; 4 HYDROXYNONENAL; CATECHIN; CYTOCHROME P450 2E1; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; FREE RADICAL; GLUTATHIONE TRANSFERASE; LIPID; PROTEIN; REACTIVE OXYGEN METABOLITE;

EID: 34547806105     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.03.017     Document Type: Article
Times cited : (44)

References (46)
  • 1
    • 3142536557 scopus 로고    scopus 로고
    • Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties
    • Azam S., Hadi N., Khan N.U., and Hadi S.M. Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties. Toxicol. In Vitro 18 (2004) 555-561
    • (2004) Toxicol. In Vitro , vol.18 , pp. 555-561
    • Azam, S.1    Hadi, N.2    Khan, N.U.3    Hadi, S.M.4
  • 2
    • 0025004502 scopus 로고
    • Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
    • Bors W., Heller W., Michel C., and Saran M. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Meth. Enzymol. 186 (1990) 343-355
    • (1990) Meth. Enzymol. , vol.186 , pp. 343-355
    • Bors, W.1    Heller, W.2    Michel, C.3    Saran, M.4
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 0037449191 scopus 로고    scopus 로고
    • Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines
    • Chai P.C., Long L.H., and Halliwell B. Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines. Biochem. Biophys. Res. Commun. 304 (2003) 650-654
    • (2003) Biochem. Biophys. Res. Commun. , vol.304 , pp. 650-654
    • Chai, P.C.1    Long, L.H.2    Halliwell, B.3
  • 6
    • 0036681836 scopus 로고    scopus 로고
    • Differential role of CYP2E1 binders and isoniazid on CYP2E1 protein modification in NADPH-dependent microsomal oxidative reactions: free radical scavenging ability of isoniazid
    • Choi D., Leininger-Muller B., Kim Y.C., Leroy P., Siest G., and Wellman M. Differential role of CYP2E1 binders and isoniazid on CYP2E1 protein modification in NADPH-dependent microsomal oxidative reactions: free radical scavenging ability of isoniazid. Free Radic. Res. 36 (2002) 893-903
    • (2002) Free Radic. Res. , vol.36 , pp. 893-903
    • Choi, D.1    Leininger-Muller, B.2    Kim, Y.C.3    Leroy, P.4    Siest, G.5    Wellman, M.6
  • 7
    • 0015791885 scopus 로고
    • Microsomal metabolism of dimethylnitrosamine and the cytochrome P450 dependency of its activation to a mutagen
    • Czygan P., Greim H., Garro A.J., Hutlerer F., Schaffiner F., Popper M., Rosenthal O., and Cooper D.Y. Microsomal metabolism of dimethylnitrosamine and the cytochrome P450 dependency of its activation to a mutagen. Cancer Res. 33 (1973) 2983-2986
    • (1973) Cancer Res. , vol.33 , pp. 2983-2986
    • Czygan, P.1    Greim, H.2    Garro, A.J.3    Hutlerer, F.4    Schaffiner, F.5    Popper, M.6    Rosenthal, O.7    Cooper, D.Y.8
  • 8
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dorge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-95
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Dorge, W.1
  • 10
    • 14644417139 scopus 로고    scopus 로고
    • Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans
    • Erba D., Riso P., Bordoni A., Foti P., Biagi P., and Testolin G.L. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J. Nut. Biochem. 16 (2005) 144-149
    • (2005) J. Nut. Biochem. , vol.16 , pp. 144-149
    • Erba, D.1    Riso, P.2    Bordoni, A.3    Foti, P.4    Biagi, P.5    Testolin, G.L.6
  • 11
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer H., Schaur R.J., and Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11 (1991) 81-128
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 12
    • 31644435641 scopus 로고    scopus 로고
    • Cellular and in vivo hepatotoxicity caused by green tea phenolics acids and catechins
    • Galati G., Lin A., Sultan A.M., and O'Brien P.J. Cellular and in vivo hepatotoxicity caused by green tea phenolics acids and catechins. Free Radic. Biol. Med. 40 (2006) 570-580
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 570-580
    • Galati, G.1    Lin, A.2    Sultan, A.M.3    O'Brien, P.J.4
  • 13
    • 0030582664 scopus 로고    scopus 로고
    • Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes
    • Guo Q., Zhao B., Li M., Shen S., and Xin W. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim. Biophys. Acta 1304 (1996) 210-222
    • (1996) Biochim. Biophys. Acta , vol.1304 , pp. 210-222
    • Guo, Q.1    Zhao, B.2    Li, M.3    Shen, S.4    Xin, W.5
  • 14
    • 0016275313 scopus 로고
    • Glutathione-S-transferase,the first enzymatic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione-S-transferase,the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 15
    • 0038706169 scopus 로고    scopus 로고
    • Radical chemistry of epigallocatechin gallate and its relevance to protein damage
    • Hagerman A.E., Dean R.T., and Davies M.J. Radical chemistry of epigallocatechin gallate and its relevance to protein damage. Arch. Biochem. Biophys. 414 (2003) 115-120
    • (2003) Arch. Biochem. Biophys. , vol.414 , pp. 115-120
    • Hagerman, A.E.1    Dean, R.T.2    Davies, M.J.3
  • 16
    • 0027465289 scopus 로고
    • role of oxygen radicals in human disease, with particular reference to the vascular system
    • Halliwell B. role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis 23 (1993) 118-126
    • (1993) Haemostasis , vol.23 , pp. 118-126
    • Halliwell, B.1
  • 17
    • 0023219256 scopus 로고
    • deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals
    • Halliwell B., Gutteridge J.M., and Aruoma O.I. deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals. Anal. Biochem. 165 (1987) 215-219
    • (1987) Anal. Biochem. , vol.165 , pp. 215-219
    • Halliwell, B.1    Gutteridge, J.M.2    Aruoma, O.I.3
  • 18
    • 0038121053 scopus 로고    scopus 로고
    • Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    • Higdon J.V., and Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 43 (2003) 89-143
    • (2003) Crit. Rev. Food Sci. Nutr. , vol.43 , pp. 89-143
    • Higdon, J.V.1    Frei, B.2
  • 19
    • 0035071758 scopus 로고    scopus 로고
    • Evaluation of antioxidant activity of epigallocatechin gallate in biphasic model systems in vitro
    • Hu C., and Kitts D.D. Evaluation of antioxidant activity of epigallocatechin gallate in biphasic model systems in vitro. Mol. Cell Biochem. 218 (2001) 147-155
    • (2001) Mol. Cell Biochem. , vol.218 , pp. 147-155
    • Hu, C.1    Kitts, D.D.2
  • 20
    • 33645224473 scopus 로고    scopus 로고
    • Safety studies on epigallocatechin gallate (EGCG) preparations.Part 2: Dermal, acute and short-term toxicity studies
    • Isbrucker R.A., Edwards J.A., Wolz E., Davidovich A., and Bausch J. Safety studies on epigallocatechin gallate (EGCG) preparations.Part 2: Dermal, acute and short-term toxicity studies. Food Chem. Toxicol. 44 (2006) 636-650
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 636-650
    • Isbrucker, R.A.1    Edwards, J.A.2    Wolz, E.3    Davidovich, A.4    Bausch, J.5
  • 21
    • 0034724758 scopus 로고    scopus 로고
    • Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA
    • Johnson M.K., and Loo G. Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA. Mutat. Res. 459 (2000) 211-218
    • (2000) Mutat. Res. , vol.459 , pp. 211-218
    • Johnson, M.K.1    Loo, G.2
  • 22
    • 33645094927 scopus 로고    scopus 로고
    • Targeting multiple signaling pathways by green tea polyphenol(-)-epigallocatechin-3-gallate
    • Khan N., Afaq F., Saleem M., Ahmad N., and Mukhtar H. Targeting multiple signaling pathways by green tea polyphenol(-)-epigallocatechin-3-gallate. Cancer Res. 66 (2006) 2500-2505
    • (2006) Cancer Res. , vol.66 , pp. 2500-2505
    • Khan, N.1    Afaq, F.2    Saleem, M.3    Ahmad, N.4    Mukhtar, H.5
  • 23
    • 0032877148 scopus 로고    scopus 로고
    • Scavenging mechanisms of (-)-epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action
    • Kondo K., Kurihara M., Miyata N., Suzuki T., and Toyoda M. Scavenging mechanisms of (-)-epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action. Free Radic. Biol. Med. 27 (1999) 855-863
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 855-863
    • Kondo, K.1    Kurihara, M.2    Miyata, N.3    Suzuki, T.4    Toyoda, M.5
  • 24
    • 0036801990 scopus 로고    scopus 로고
    • Pharmacokinetics of tea catechins after ingestion of green tea and (-) epigallocatechin-3-gallate by humans:formation of different metabolites and individual variability
    • Lee M.-J., Maliakal P., Chen L., Meng X., Bondoc F.Y., Prabhu S., Lambert G., Mohr S., and Yang C.S. Pharmacokinetics of tea catechins after ingestion of green tea and (-) epigallocatechin-3-gallate by humans:formation of different metabolites and individual variability. Cancer Epidemiol. Biomark. Prev. 11 (2002) 1025-1032
    • (2002) Cancer Epidemiol. Biomark. Prev. , vol.11 , pp. 1025-1032
    • Lee, M.-J.1    Maliakal, P.2    Chen, L.3    Meng, X.4    Bondoc, F.Y.5    Prabhu, S.6    Lambert, G.7    Mohr, S.8    Yang, C.S.9
  • 26
    • 0031941373 scopus 로고    scopus 로고
    • Validation of lucigenin (bis-N-methylacrydium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems
    • Li Y., Zhu H., Kuppusamy P., Roubod V., Zweir J., and Trush M.A. Validation of lucigenin (bis-N-methylacrydium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J. Biol. Chem. 273 (1998) 2015-2023
    • (1998) J. Biol. Chem. , vol.273 , pp. 2015-2023
    • Li, Y.1    Zhu, H.2    Kuppusamy, P.3    Roubod, V.4    Zweir, J.5    Trush, M.A.6
  • 27
    • 19944432813 scopus 로고    scopus 로고
    • Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycooxidation and cross-linking
    • Mustata G.T., Rosca M., Biemel K.M., Reihl O., Smith M.A., Viswanathan A., Strauch C., Du Y., Tang J., Kern T.S., Lederer M.O., Brownlee M., Weiss M.F., and Monnier V.M. Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: Improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycooxidation and cross-linking. Diabetes 54 (2005) 517-526
    • (2005) Diabetes , vol.54 , pp. 517-526
    • Mustata, G.T.1    Rosca, M.2    Biemel, K.M.3    Reihl, O.4    Smith, M.A.5    Viswanathan, A.6    Strauch, C.7    Du, Y.8    Tang, J.9    Kern, T.S.10    Lederer, M.O.11    Brownlee, M.12    Weiss, M.F.13    Monnier, V.M.14
  • 28
  • 29
    • 0018384650 scopus 로고
    • Assay of lipidperoxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Oshishi N., and Yagi K. Assay of lipidperoxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Oshishi, N.2    Yagi, K.3
  • 30
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Pagila D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70 (1967) 158-169
    • (1967) J. Lab. Clin. Med. , vol.70 , pp. 158-169
    • Pagila, D.E.1    Valentine, W.N.2
  • 31
    • 0027218413 scopus 로고
    • Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment
    • Rashba-Step J., Turro N.J., and Cederbaum A.I. Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch. Biochem. Biophys. 300 (1993) 401-408
    • (1993) Arch. Biochem. Biophys. , vol.300 , pp. 401-408
    • Rashba-Step, J.1    Turro, N.J.2    Cederbaum, A.I.3
  • 32
    • 23944513613 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments
    • Raza H., and John A. Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. Toxicol. Appl. Pharmacol. 207 (2005) 212-220
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , pp. 212-220
    • Raza, H.1    John, A.2
  • 33
    • 0037103764 scopus 로고    scopus 로고
    • isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress
    • Raza H., Robin M.A., Fang J.K., and Avadhani N.G. isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem. J. 366 (2002) 45-55
    • (2002) Biochem. J. , vol.366 , pp. 45-55
    • Raza, H.1    Robin, M.A.2    Fang, J.K.3    Avadhani, N.G.4
  • 34
    • 0347360363 scopus 로고    scopus 로고
    • Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress
    • Raza H., Prabu S.K., Robin M.A., and Avadhani N.G. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Diabetes 53 (2004) 185-194
    • (2004) Diabetes , vol.53 , pp. 185-194
    • Raza, H.1    Prabu, S.K.2    Robin, M.A.3    Avadhani, N.G.4
  • 35
    • 0028239163 scopus 로고
    • Damage to proteins: spectrophotometric method for carbonyl assay
    • Reznick A.Z., and Packer L. Damage to proteins: spectrophotometric method for carbonyl assay. Meth. Enzymol. 233 (1994) 357-363
    • (1994) Meth. Enzymol. , vol.233 , pp. 357-363
    • Reznick, A.Z.1    Packer, L.2
  • 36
    • 0029888128 scopus 로고    scopus 로고
    • Structure antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans C.A., Miller N.J., and Paganga G. Structure antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20 (1996) 933-956
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 37
    • 0038387937 scopus 로고    scopus 로고
    • Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite
    • Schroeder P., Klotz L.O., and Sies H. Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite. Biochem. Biophys. Res. Commun. 307 (2003) 69-73
    • (2003) Biochem. Biophys. Res. Commun. , vol.307 , pp. 69-73
    • Schroeder, P.1    Klotz, L.O.2    Sies, H.3
  • 39
    • 4344691399 scopus 로고    scopus 로고
    • A review of the epidemiological evidence for the "antioxidant hypothesis"
    • Stanner S.A., Hughes J., Kelly C.N., and Buttris J. A review of the epidemiological evidence for the "antioxidant hypothesis". Pub. Health Nut. 7 (2004) 407-422
    • (2004) Pub. Health Nut. , vol.7 , pp. 407-422
    • Stanner, S.A.1    Hughes, J.2    Kelly, C.N.3    Buttris, J.4
  • 40
    • 18844369559 scopus 로고    scopus 로고
    • Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase
    • Steffen Y., Schewe T., and Sies H. Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase. Biochem. Biophys. Res. Commun. 331 (2005) 1277-1283
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , pp. 1277-1283
    • Steffen, Y.1    Schewe, T.2    Sies, H.3
  • 41
    • 15944365828 scopus 로고    scopus 로고
    • Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex
    • Sugihara N., Kaneko A., and Furuno K. Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex. Free Radic. Res. 39 (2005) 237-244
    • (2005) Free Radic. Res. , vol.39 , pp. 237-244
    • Sugihara, N.1    Kaneko, A.2    Furuno, K.3
  • 42
    • 0033805735 scopus 로고    scopus 로고
    • Antioxidant chemistry of green tea catechins. New oxidation products of (-)-epigallocatechin gallate and (-)-epigallocatechin from their reactions with peroxyl radicals
    • Valcic S., Burr J.A., Timmermann B.N., and Liebler D.C. Antioxidant chemistry of green tea catechins. New oxidation products of (-)-epigallocatechin gallate and (-)-epigallocatechin from their reactions with peroxyl radicals. Chem. Res. Toxicol. 13 (2000) 801-810
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 801-810
    • Valcic, S.1    Burr, J.A.2    Timmermann, B.N.3    Liebler, D.C.4
  • 43
    • 18844408406 scopus 로고    scopus 로고
    • Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats
    • Volkel W., Alvarez-Sanchez R., Weick I., Mally A., Dekant W., and Pahler A. Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats. Free Radic. Biol. Med. 38 (2005) 1526-1536
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 1526-1536
    • Volkel, W.1    Alvarez-Sanchez, R.2    Weick, I.3    Mally, A.4    Dekant, W.5    Pahler, A.6
  • 44
    • 0028360527 scopus 로고
    • Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carconogenesis in 7,12 dimethylbenz[a]anthracene-initiated SKH-1 mice
    • Wang Z.Y., Huang M.T., Lou Y.R., Xie J.G., Reuhl K.R., Newmark H.L., Ho C.T., Yang C.S., and Conney A.H. Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carconogenesis in 7,12 dimethylbenz[a]anthracene-initiated SKH-1 mice. Cancer Res. 54 (1994) 3428-3435
    • (1994) Cancer Res. , vol.54 , pp. 3428-3435
    • Wang, Z.Y.1    Huang, M.T.2    Lou, Y.R.3    Xie, J.G.4    Reuhl, K.R.5    Newmark, H.L.6    Ho, C.T.7    Yang, C.S.8    Conney, A.H.9
  • 46
    • 11844269261 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high dose green tea extracts
    • Zhou Y.D., Kim Y.P., Li X.C., Baerson S.R., Agarwal A.K., Hodges T.W., Ferreira D., and Nagle D.G. Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high dose green tea extracts. J. Natu. Prod. 67 (2004) 2063-2069
    • (2004) J. Natu. Prod. , vol.67 , pp. 2063-2069
    • Zhou, Y.D.1    Kim, Y.P.2    Li, X.C.3    Baerson, S.R.4    Agarwal, A.K.5    Hodges, T.W.6    Ferreira, D.7    Nagle, D.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.