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Volumn 173, Issue , 2008, Pages 375-384

Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation

Author keywords

glaucoma; monocytes; neurodegenerative diseases; neuroprotection; optic neuropathy; protective autoimmunity; secondary degeneration; therapeutic vaccination

Indexed keywords

CALCIUM; FREE RADICAL; GLATIRAMER; GLUTAMIC ACID; GROWTH FACTOR; MEMANTINE; NEUROTROPHIN;

EID: 53049109849     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)01126-6     Document Type: Review
Times cited : (19)

References (95)
  • 1
    • 0028971936 scopus 로고
    • Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis
    • Abe K., Pan L.H., Watanabe M., Kato T., and Itoyama Y. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci. Lett. 199 (1995) 152-154
    • (1995) Neurosci. Lett. , vol.199 , pp. 152-154
    • Abe, K.1    Pan, L.H.2    Watanabe, M.3    Kato, T.4    Itoyama, Y.5
  • 2
    • 3142514196 scopus 로고    scopus 로고
    • Oxidative stress in neurodegeneration: cause or consequence?
    • Andersen J.K. Oxidative stress in neurodegeneration: cause or consequence?. Nat. Med. 10 Suppl (2004) S18-S25
    • (2004) Nat. Med. , vol.10 , Issue.SUPPL
    • Andersen, J.K.1
  • 3
    • 10944246635 scopus 로고    scopus 로고
    • Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells
    • Avidan H., Kipnis J., Butovsky O., Caspi R.R., and Schwartz M. Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells. Eur. J. Immunol. 34 (2004) 3434-3445
    • (2004) Eur. J. Immunol. , vol.34 , pp. 3434-3445
    • Avidan, H.1    Kipnis, J.2    Butovsky, O.3    Caspi, R.R.4    Schwartz, M.5
  • 5
    • 0036319750 scopus 로고    scopus 로고
    • Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent
    • Bakalash S., Kipnis J., Yoles E., and Schwartz M. Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2648-2653
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , pp. 2648-2653
    • Bakalash, S.1    Kipnis, J.2    Yoles, E.3    Schwartz, M.4
  • 6
    • 27744603039 scopus 로고    scopus 로고
    • T-cell-based vaccination for morphological and functional neuroprotection in a rat model of chronically elevated intraocular pressure
    • Bakalash S., Shlomo G.B., Aloni E., Shaked I., Wheeler L., Ofri R., and Schwartz M. T-cell-based vaccination for morphological and functional neuroprotection in a rat model of chronically elevated intraocular pressure. J. Mol. Med. 83 (2005) 904-916
    • (2005) J. Mol. Med. , vol.83 , pp. 904-916
    • Bakalash, S.1    Shlomo, G.B.2    Aloni, E.3    Shaked, I.4    Wheeler, L.5    Ofri, R.6    Schwartz, M.7
  • 7
    • 0036674498 scopus 로고    scopus 로고
    • Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: Implications for protective autoimmunity
    • Barouch R., and Schwartz M. Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: Implications for protective autoimmunity. FASEB J. 16 (2002) 1304-1306
    • (2002) FASEB J. , vol.16 , pp. 1304-1306
    • Barouch, R.1    Schwartz, M.2
  • 9
    • 0031711224 scopus 로고    scopus 로고
    • Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis
    • Beal M.F. Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Ann. Neurol. 44 (1998) S110-S114
    • (1998) Ann. Neurol. , vol.44
    • Beal, M.F.1
  • 13
    • 0029928691 scopus 로고    scopus 로고
    • Delayed functional loss in glaucoma. LII Edward Jackson Memorial Lecture
    • Brubaker R.F. Delayed functional loss in glaucoma. LII Edward Jackson Memorial Lecture. Am. J. Ophthalmol. 121 (1996) 473-483
    • (1996) Am. J. Ophthalmol. , vol.121 , pp. 473-483
    • Brubaker, R.F.1
  • 14
    • 8844276650 scopus 로고    scopus 로고
    • The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage
    • Burgoyne C.F., Downs J.C., Bellezza A.J., Suh J.K., and Hart R.T. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog. Retin. Eye Res. 24 (2005) 39-73
    • (2005) Prog. Retin. Eye Res. , vol.24 , pp. 39-73
    • Burgoyne, C.F.1    Downs, J.C.2    Bellezza, A.J.3    Suh, J.K.4    Hart, R.T.5
  • 15
    • 0035315852 scopus 로고    scopus 로고
    • Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation
    • Butovsky O., Hauben E., and Schwartz M. Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation. FASEB J. 15 (2001) 1065-1067
    • (2001) FASEB J. , vol.15 , pp. 1065-1067
    • Butovsky, O.1    Hauben, E.2    Schwartz, M.3
  • 16
    • 20444364844 scopus 로고    scopus 로고
    • Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective
    • Butovsky O., Talpalar A.E., Ben-Yaakov K., and Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol. Cell. Neurosci. 29 (2005) 381-393
    • (2005) Mol. Cell. Neurosci. , vol.29 , pp. 381-393
    • Butovsky, O.1    Talpalar, A.E.2    Ben-Yaakov, K.3    Schwartz, M.4
  • 18
    • 0026784237 scopus 로고
    • The relationship between intraocular pressure and visual field progression in glaucoma
    • Chauhan B.C., and Drance S.M. The relationship between intraocular pressure and visual field progression in glaucoma. Graefes Arch. Clin. Exp. Ophthalmol. 230 (1992) 521-526
    • (1992) Graefes Arch. Clin. Exp. Ophthalmol. , vol.230 , pp. 521-526
    • Chauhan, B.C.1    Drance, S.M.2
  • 19
    • 34047212129 scopus 로고    scopus 로고
    • Pharmacological neuroprotection for glaucoma
    • Chidlow G., Wood J.P., and Casson R.J. Pharmacological neuroprotection for glaucoma. Drugs 67 (2007) 725-759
    • (2007) Drugs , vol.67 , pp. 725-759
    • Chidlow, G.1    Wood, J.P.2    Casson, R.J.3
  • 20
    • 0023753142 scopus 로고
    • Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
    • Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11 (1988) 465-469
    • (1988) Trends Neurosci. , vol.11 , pp. 465-469
    • Choi, D.W.1
  • 21
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 22
    • 0031937195 scopus 로고    scopus 로고
    • A proposed role for excitotoxicity in glaucoma
    • Dreyer E.B. A proposed role for excitotoxicity in glaucoma. J. Glaucoma 7 (1998) 62-67
    • (1998) J. Glaucoma , vol.7 , pp. 62-67
    • Dreyer, E.B.1
  • 24
    • 0030826644 scopus 로고    scopus 로고
    • Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury
    • Gao H., Qiao X., Hefti F., Hollyfield J.G., and Knusel B. Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. Invest. Ophthalmol. Vis. Sci. 38 (1997) 1840-1847
    • (1997) Invest. Ophthalmol. Vis. Sci. , vol.38 , pp. 1840-1847
    • Gao, H.1    Qiao, X.2    Hefti, F.3    Hollyfield, J.G.4    Knusel, B.5
  • 26
    • 33847034391 scopus 로고    scopus 로고
    • Glaucoma as a neurodegenerative disease
    • Gupta N., and Yucel Y.H. Glaucoma as a neurodegenerative disease. Curr. Opin. Ophthalmol. 18 (2007) 110-114
    • (2007) Curr. Opin. Ophthalmol. , vol.18 , pp. 110-114
    • Gupta, N.1    Yucel, Y.H.2
  • 27
    • 0035106419 scopus 로고    scopus 로고
    • Beyond intraocular pressure: neuroprotective strategies for future glaucoma therapy
    • Hartwick A.T. Beyond intraocular pressure: neuroprotective strategies for future glaucoma therapy. Optom. Vis. Sci. 78 (2001) 85-94
    • (2001) Optom. Vis. Sci. , vol.78 , pp. 85-94
    • Hartwick, A.T.1
  • 28
    • 0034893791 scopus 로고    scopus 로고
    • Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease
    • Hauben E., Agranov E., Gothilf A., Nevo U., Cohen A., Smirnov I., Steinman L., and Schwartz M. Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease. J. Clin. Invest. 108 (2001) 591-599
    • (2001) J. Clin. Invest. , vol.108 , pp. 591-599
    • Hauben, E.1    Agranov, E.2    Gothilf, A.3    Nevo, U.4    Cohen, A.5    Smirnov, I.6    Steinman, L.7    Schwartz, M.8
  • 29
    • 0036822851 scopus 로고    scopus 로고
    • Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial
    • Heijl A., Leske M.C., Bengtsson B., Hyman L., Bengtsson B., and Hussein M. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch. Ophthalmol. 120 (2002) 1268-1279
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 1268-1279
    • Heijl, A.1    Leske, M.C.2    Bengtsson, B.3    Hyman, L.4    Bengtsson, B.5    Hussein, M.6
  • 30
    • 0024820051 scopus 로고
    • The benefit of early trabeculectomy versus conventional management in primary open angle glaucoma relative to severity of disease
    • Jay J.L., and Allan D. The benefit of early trabeculectomy versus conventional management in primary open angle glaucoma relative to severity of disease. Eye 3 Pt 5 (1989) 528-535
    • (1989) Eye , vol.3 , Issue.PART 5 , pp. 528-535
    • Jay, J.L.1    Allan, D.2
  • 31
    • 33646875735 scopus 로고    scopus 로고
    • The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models
    • Johnson E.C., Cepurna W.O., Jia L., and Morrison J.C. The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models. Exp. Eye Res. 83 (2006) 51-60
    • (2006) Exp. Eye Res. , vol.83 , pp. 51-60
    • Johnson, E.C.1    Cepurna, W.O.2    Jia, L.3    Morrison, J.C.4
  • 32
    • 0036269833 scopus 로고    scopus 로고
    • The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
    • discussion 829-730
    • Kass M.A., Heuer D.K., Higginbotham E.J., Johnson C.A., Keltner J.L., Miller J.P., Parrish II R.K., Wilson M.R., and Gordon M.O. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch. Ophthalmol. 120 (2002) 701-713 discussion 829-730
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 701-713
    • Kass, M.A.1    Heuer, D.K.2    Higginbotham, E.J.3    Johnson, C.A.4    Keltner, J.L.5    Miller, J.P.6    Parrish II, R.K.7    Wilson, M.R.8    Gordon, M.O.9
  • 33
    • 3042801077 scopus 로고    scopus 로고
    • Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration
    • Kipnis J., Cardon M., Avidan H., Lewitus G.M., Mordechay S., Rolls A., Shani Y., and Schwartz M. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J. Neurosci. 24 (2004) 6133-6143
    • (2004) J. Neurosci. , vol.24 , pp. 6133-6143
    • Kipnis, J.1    Cardon, M.2    Avidan, H.3    Lewitus, G.M.4    Mordechay, S.5    Rolls, A.6    Shani, Y.7    Schwartz, M.8
  • 34
    • 0037180556 scopus 로고    scopus 로고
    • Neuroprotective autoimmunity: Naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system
    • Kipnis J., Mizrahi T., Hauben E., Shaked I., Shevach E., and Schwartz M. Neuroprotective autoimmunity: Naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 15620-15625
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 15620-15625
    • Kipnis, J.1    Mizrahi, T.2    Hauben, E.3    Shaked, I.4    Shevach, E.5    Schwartz, M.6
  • 35
    • 0034691136 scopus 로고    scopus 로고
    • T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies
    • Kipnis J., Yoles E., Porat Z., Cohen A., Mor F., Sela M., Cohen I.R., and Schwartz M. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 7446-7451
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 7446-7451
    • Kipnis, J.1    Yoles, E.2    Porat, Z.3    Cohen, A.4    Mor, F.5    Sela, M.6    Cohen, I.R.7    Schwartz, M.8
  • 36
    • 0031940544 scopus 로고    scopus 로고
    • Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo
    • Klocker N., Cellerino A., and Bahr M. Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo. J. Neurosci. 18 (1998) 1038-1046
    • (1998) J. Neurosci. , vol.18 , pp. 1038-1046
    • Klocker, N.1    Cellerino, A.2    Bahr, M.3
  • 37
    • 0031765270 scopus 로고    scopus 로고
    • Glutamate toxicity in chronic neurodegenerative disease
    • Lancelot E., and Beal M.F. Glutamate toxicity in chronic neurodegenerative disease. Prog. Brain Res. 116 (1998) 331-347
    • (1998) Prog. Brain Res. , vol.116 , pp. 331-347
    • Lancelot, E.1    Beal, M.F.2
  • 38
    • 33750361540 scopus 로고    scopus 로고
    • A century-old debate on protein aggregation and neurodegeneration enters the clinic
    • Lansbury P.T., and Lashuel H.A. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 443 (2006) 774-779
    • (2006) Nature , vol.443 , pp. 774-779
    • Lansbury, P.T.1    Lashuel, H.A.2
  • 39
    • 0037251618 scopus 로고    scopus 로고
    • Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial
    • Leske M.C., Heijl A., Hussein M., Bengtsson B., Hyman L., and Komaroff E. Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch. Ophthalmol. 121 (2003) 48-56
    • (2003) Arch. Ophthalmol. , vol.121 , pp. 48-56
    • Leske, M.C.1    Heijl, A.2    Hussein, M.3    Bengtsson, B.4    Hyman, L.5    Komaroff, E.6
  • 42
    • 34249093924 scopus 로고    scopus 로고
    • Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation
    • Lipton S.A. Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Curr. Drug Targets 8 (2007) 621-632
    • (2007) Curr. Drug Targets , vol.8 , pp. 621-632
    • Lipton, S.A.1
  • 43
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton S.A., and Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330 (1994) 613-622
    • (1994) N. Engl. J. Med. , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 44
    • 0028324822 scopus 로고
    • Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
    • Mansour-Robaey S., Clarke D.B., Wang Y.C., Bray G.M., and Aguayo A.J. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 1632-1636
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 1632-1636
    • Mansour-Robaey, S.1    Clarke, D.B.2    Wang, Y.C.3    Bray, G.M.4    Aguayo, A.J.5
  • 45
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: signaling for suicide and survival
    • Martindale J.L., and Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell Physiol. 192 (2002) 1-15
    • (2002) J. Cell Physiol. , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 47
    • 0037111317 scopus 로고    scopus 로고
    • The tissue-specific self-pathogen is the protective self-antigen: the case of uveitis
    • Mizrahi T., Hauben E., and Schwartz M. The tissue-specific self-pathogen is the protective self-antigen: the case of uveitis. J. Immunol. 169 (2002) 5971-5977
    • (2002) J. Immunol. , vol.169 , pp. 5971-5977
    • Mizrahi, T.1    Hauben, E.2    Schwartz, M.3
  • 48
    • 0033712614 scopus 로고    scopus 로고
    • Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity
    • Moalem G., Gdalyahu A., Shani Y., Otten U., Lazarovici P., Cohen I.R., and Schwartz M. Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J. Autoimmun. 15 (2000) 331-345
    • (2000) J. Autoimmun. , vol.15 , pp. 331-345
    • Moalem, G.1    Gdalyahu, A.2    Shani, Y.3    Otten, U.4    Lazarovici, P.5    Cohen, I.R.6    Schwartz, M.7
  • 49
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • Moalem G., Leibowitz-Amit R., Yoles E., Mor F., Cohen I.R., and Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5 (1999) 49-55
    • (1999) Nat. Med. , vol.5 , pp. 49-55
    • Moalem, G.1    Leibowitz-Amit, R.2    Yoles, E.3    Mor, F.4    Cohen, I.R.5    Schwartz, M.6
  • 50
    • 35848953211 scopus 로고    scopus 로고
    • Is there more to glaucoma treatment than lowering IOP?
    • Mozaffarieh M., and Flammer J. Is there more to glaucoma treatment than lowering IOP?. Surv. Ophthalmol. 52 Suppl 2 (2007) S174-S179
    • (2007) Surv. Ophthalmol. , vol.52 , Issue.SUPPL. 2
    • Mozaffarieh, M.1    Flammer, J.2
  • 51
    • 0032988397 scopus 로고    scopus 로고
    • Reduced glutamate uptake by retinal glial cells under ischemic/hypoxic conditions
    • Napper G.A., Pianta M.J., and Kalloniatis M. Reduced glutamate uptake by retinal glial cells under ischemic/hypoxic conditions. Vis. Neurosci. 16 (1999) 149-158
    • (1999) Vis. Neurosci. , vol.16 , pp. 149-158
    • Napper, G.A.1    Pianta, M.J.2    Kalloniatis, M.3
  • 52
    • 0033578378 scopus 로고    scopus 로고
    • Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma
    • Neufeld A.H., Sawada A., and Becker B. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 9944-9948
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 9944-9948
    • Neufeld, A.H.1    Sawada, A.2    Becker, B.3
  • 53
    • 34248144933 scopus 로고    scopus 로고
    • From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma
    • Nickells R.W. From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma. Can. J. Ophthalmol. 42 (2007) 278-287
    • (2007) Can. J. Ophthalmol. , vol.42 , pp. 278-287
    • Nickells, R.W.1
  • 56
    • 0030729743 scopus 로고    scopus 로고
    • Retinal toxicity of nitric oxide released by administration of a nitric oxide donor in the albino rabbit
    • Oku H., Yamaguchi H., Sugiyama T., Kojima S., Ota M., and Azuma I. Retinal toxicity of nitric oxide released by administration of a nitric oxide donor in the albino rabbit. Invest. Ophthalmol. Vis. Sci. 38 (1997) 2540-2544
    • (1997) Invest. Ophthalmol. Vis. Sci. , vol.38 , pp. 2540-2544
    • Oku, H.1    Yamaguchi, H.2    Sugiyama, T.3    Kojima, S.4    Ota, M.5    Azuma, I.6
  • 57
    • 0014544544 scopus 로고
    • Glutaate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion
    • Olney J.W. Glutaate-induced retinal degeneration in neonatal mice. Electron microscopy of the acutely evolving lesion. J. Neuropathol. Exp. Neurol. 28 (1969) 455-474
    • (1969) J. Neuropathol. Exp. Neurol. , vol.28 , pp. 455-474
    • Olney, J.W.1
  • 59
    • 0028149786 scopus 로고
    • Checkpoints of dueling dimers foil death wishes
    • Oltvai Z.N., and Korsmeyer S.J. Checkpoints of dueling dimers foil death wishes. Cell 79 (1994) 189-192
    • (1994) Cell , vol.79 , pp. 189-192
    • Oltvai, Z.N.1    Korsmeyer, S.J.2
  • 60
    • 0029979673 scopus 로고    scopus 로고
    • Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study
    • Peinado-Ramon P., Salvador M., Villegas-Perez M.P., and Vidal-Sanz M. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Invest. Ophthalmol. Vis. Sci. 37 (1996) 489-500
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 489-500
    • Peinado-Ramon, P.1    Salvador, M.2    Villegas-Perez, M.P.3    Vidal-Sanz, M.4
  • 61
    • 33644648172 scopus 로고    scopus 로고
    • The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease
    • Potashkin J.A., and Meredith G.E. The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease. Antioxid. Redox Signal. 8 (2006) 144-151
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 144-151
    • Potashkin, J.A.1    Meredith, G.E.2
  • 62
    • 0032889607 scopus 로고    scopus 로고
    • Neuronal death in glaucoma
    • Quigley H.A. Neuronal death in glaucoma. Prog. Retin. Eye Res. 18 (1999) 39-57
    • (1999) Prog. Retin. Eye Res. , vol.18 , pp. 39-57
    • Quigley, H.A.1
  • 63
    • 0018386277 scopus 로고
    • Long-term follow-up of treated open-angle glaucoma
    • Quigley H.A., and Maumenee A.E. Long-term follow-up of treated open-angle glaucoma. Am. J. Ophthalmol. 87 (1979) 519-525
    • (1979) Am. J. Ophthalmol. , vol.87 , pp. 519-525
    • Quigley, H.A.1    Maumenee, A.E.2
  • 64
    • 0020445566 scopus 로고
    • Risk factors for progression of visual field defects in medically treated patients with glaucoma
    • Richler M., Werner E.B., and Thomas D. Risk factors for progression of visual field defects in medically treated patients with glaucoma. Can. J. Ophthalmol. 17 (1982) 245-248
    • (1982) Can. J. Ophthalmol. , vol.17 , pp. 245-248
    • Richler, M.1    Werner, E.B.2    Thomas, D.3
  • 65
    • 33750444913 scopus 로고    scopus 로고
    • From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain
    • Riederer P., and Hoyer S. From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain. J. Neural Transm. 113 (2006) 1671-1677
    • (2006) J. Neural Transm. , vol.113 , pp. 1671-1677
    • Riederer, P.1    Hoyer, S.2
  • 66
    • 0034116017 scopus 로고    scopus 로고
    • Potential role for Ginkgo biloba extract in the treatment of glaucoma
    • Ritch R. Potential role for Ginkgo biloba extract in the treatment of glaucoma. Med. Hypotheses 54 (2000) 221-235
    • (2000) Med. Hypotheses , vol.54 , pp. 221-235
    • Ritch, R.1
  • 67
    • 0033535779 scopus 로고    scopus 로고
    • Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins
    • Rocha M., Martins R.A., and Linden R. Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins. Brain Res. 827 (1999) 79-92
    • (1999) Brain Res. , vol.827 , pp. 79-92
    • Rocha, M.1    Martins, R.A.2    Linden, R.3
  • 69
    • 0035853085 scopus 로고    scopus 로고
    • Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma
    • Schori H., Kipnis J., Yoles E., WoldeMussie E., Ruiz G., Wheeler L.A., and Schwartz M. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 3398-3403
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 3398-3403
    • Schori, H.1    Kipnis, J.2    Yoles, E.3    WoldeMussie, E.4    Ruiz, G.5    Wheeler, L.A.6    Schwartz, M.7
  • 71
    • 0037377893 scopus 로고    scopus 로고
    • Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture
    • Schwartz M. Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1407-1411
    • (2003) Invest. Ophthalmol. Vis. Sci. , vol.44 , pp. 1407-1411
    • Schwartz, M.1
  • 72
    • 22544479099 scopus 로고    scopus 로고
    • Lessons for glaucoma from other neurodegenerative diseases: can one treatment suit them all?
    • Schwartz M. Lessons for glaucoma from other neurodegenerative diseases: can one treatment suit them all?. J. Glaucoma 14 (2005) 321-323
    • (2005) J. Glaucoma , vol.14 , pp. 321-323
    • Schwartz, M.1
  • 73
    • 34250678472 scopus 로고    scopus 로고
    • Modulating the immune system: a vaccine for glaucoma?
    • Schwartz M. Modulating the immune system: a vaccine for glaucoma?. Can. J. Ophthalmol. 42 (2007) 439-441
    • (2007) Can. J. Ophthalmol. , vol.42 , pp. 439-441
    • Schwartz, M.1
  • 74
    • 0029904475 scopus 로고    scopus 로고
    • Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration
    • Schwartz M., Belkin M., Yoles E., and Solomon A. Potential treatment modalities for glaucomatous neuropathy: neuroprotection and neuroregeneration. J. Glaucoma 5 (1996) 427-432
    • (1996) J. Glaucoma , vol.5 , pp. 427-432
    • Schwartz, M.1    Belkin, M.2    Yoles, E.3    Solomon, A.4
  • 75
    • 14844309321 scopus 로고    scopus 로고
    • Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators
    • Shaked I., Tchroesh D., Gersner R., Meiri G., Mordechai S., Xiao X., Hart R.P., and Schwartz M. Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators. J. Neurochem. 92 (2005) 997-1009
    • (2005) J. Neurochem. , vol.92 , pp. 997-1009
    • Shaked, I.1    Tchroesh, D.2    Gersner, R.3    Meiri, G.4    Mordechai, S.5    Xiao, X.6    Hart, R.P.7    Schwartz, M.8
  • 78
    • 33645109024 scopus 로고    scopus 로고
    • Protective effects of melatonin in experimental free radical-related ocular diseases
    • Siu A.W., Maldonado M., Sanchez-Hidalgo M., Tan D.X., and Reiter R.J. Protective effects of melatonin in experimental free radical-related ocular diseases. J. Pineal Res. 40 (2006) 101-109
    • (2006) J. Pineal Res. , vol.40 , pp. 101-109
    • Siu, A.W.1    Maldonado, M.2    Sanchez-Hidalgo, M.3    Tan, D.X.4    Reiter, R.J.5
  • 79
    • 0030175747 scopus 로고    scopus 로고
    • In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection
    • Stuiver B.T., Douma B.R., Bakker R., Nyakas C., and Luiten P.G. In vivo protection against NMDA-induced neurodegeneration by MK-801 and nimodipine: combined therapy and temporal course of protection. Neurodegeneration 5 (1996) 153-159
    • (1996) Neurodegeneration , vol.5 , pp. 153-159
    • Stuiver, B.T.1    Douma, B.R.2    Bakker, R.3    Nyakas, C.4    Luiten, P.G.5
  • 80
    • 0030728050 scopus 로고    scopus 로고
    • Molecular basis of glutamate toxicity in retinal ganglion cells
    • Sucher N.J., Lipton S.A., and Dreyer E.B. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res. 37 (1997) 3483-3493
    • (1997) Vision Res. , vol.37 , pp. 3483-3493
    • Sucher, N.J.1    Lipton, S.A.2    Dreyer, E.B.3
  • 82
    • 0026652469 scopus 로고
    • Protective effects of flunarizine on ischemic injury in the rat retina
    • Takahashi K., Lam T.T., Edward D.P., Buchi E.R., and Tso M.O. Protective effects of flunarizine on ischemic injury in the rat retina. Arch. Ophthalmol. 110 (1992) 862-870
    • (1992) Arch. Ophthalmol. , vol.110 , pp. 862-870
    • Takahashi, K.1    Lam, T.T.2    Edward, D.P.3    Buchi, E.R.4    Tso, M.O.5
  • 83
    • 33748677104 scopus 로고    scopus 로고
    • Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences
    • Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog. Retin. Eye Res. 25 (2006) 490-513
    • (2006) Prog. Retin. Eye Res. , vol.25 , pp. 490-513
    • Tezel, G.1
  • 84
    • 0034071397 scopus 로고    scopus 로고
    • Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes
    • Tezel G., Hernandez R., and Wax M.B. Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch. Ophthalmol. 118 (2000) 511-518
    • (2000) Arch. Ophthalmol. , vol.118 , pp. 511-518
    • Tezel, G.1    Hernandez, R.2    Wax, M.B.3
  • 85
    • 0037329386 scopus 로고    scopus 로고
    • Glial modulation of retinal ganglion cell death in glaucoma
    • Tezel G., and Wax M.B. Glial modulation of retinal ganglion cell death in glaucoma. J. Glaucoma 12 (2003) 63-68
    • (2003) J. Glaucoma , vol.12 , pp. 63-68
    • Tezel, G.1    Wax, M.B.2
  • 86
    • 4444275866 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head
    • Tezel G., and Wax M.B. Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch. Ophthalmol. 122 (2004) 1348-1356
    • (2004) Arch. Ophthalmol. , vol.122 , pp. 1348-1356
    • Tezel, G.1    Wax, M.B.2
  • 87
    • 27244444388 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma
    • Tezel G., Yang X., and Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest. Ophthalmol. Vis. Sci. 46 (2005) 3177-3187
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 3177-3187
    • Tezel, G.1    Yang, X.2    Cai, J.3
  • 88
    • 0032078217 scopus 로고    scopus 로고
    • Caspases: key mediators of apoptosis
    • Thornberry N.A. Caspases: key mediators of apoptosis. Chem. Biol. 5 (1998) R97-R103
    • (1998) Chem. Biol. , vol.5
    • Thornberry, N.A.1
  • 89
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: enemies within
    • Thornberry N.A., and Lazebnik Y. Caspases: enemies within. Science 281 (1998) 1312-1316
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 91
    • 0028198705 scopus 로고
    • Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor
    • Unoki K., and LaVail M.M. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Invest. Ophthalmol. Vis. Sci. 35 (1994) 907-915
    • (1994) Invest. Ophthalmol. Vis. Sci. , vol.35 , pp. 907-915
    • Unoki, K.1    LaVail, M.M.2
  • 92
    • 33751229311 scopus 로고    scopus 로고
    • The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
    • Van Den Bosch L., Van Damme P., Bogaert E., and Robberecht W. The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim. Biophys. Acta 1762 (2006) 1068-1082
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 1068-1082
    • Van Den Bosch, L.1    Van Damme, P.2    Bogaert, E.3    Robberecht, W.4
  • 93
    • 2442643730 scopus 로고    scopus 로고
    • Primary open-angle glaucoma
    • Weinreb R.N., and Khaw P.T. Primary open-angle glaucoma. Lancet 363 (2004) 1711-1720
    • (2004) Lancet , vol.363 , pp. 1711-1720
    • Weinreb, R.N.1    Khaw, P.T.2
  • 94
    • 33746689084 scopus 로고    scopus 로고
    • Targeting protein aggregation in neurodegeneration - lessons from polyglutamine disorders
    • Weydt P., and La Spada A.R. Targeting protein aggregation in neurodegeneration - lessons from polyglutamine disorders. Expert Opin. Ther. Targets 10 (2006) 505-513
    • (2006) Expert Opin. Ther. Targets , vol.10 , pp. 505-513
    • Weydt, P.1    La Spada, A.R.2


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