Identification of degradation products in loxoprofen sodium adhesive tapes by liquid chromatography-mass spectrometry and dynamic pressurized liquid extraction-solid-phase extraction coupled to liquid chromatography-nuclear magnetic resonance spectroscopy

Journal of Chromatography A

Volumn 1208, Issue 1-2, 2008, Pages 164-174

  Murakami, Tomonori ^a,d   Kawasaki, Takao ^a,b,c   Takemura, Akira ^a   Fukutsu, Naoto ^a   Kishi, Naoyuki ^a   Kusu, Fumiyo ^d  

^a DAIICHI SANKYO CO   (Japan)

^b Institute of Applied Medicine Inc   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Degradation product; Identification; LC MS; LC NMR; Loxoprofen sodium adhesive tape; Pressurized liquid extraction; Solid phase extraction

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CONCENTRATION (PROCESS); DEGRADATION; DYNAMIC POSITIONING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; LIQUID CHROMATOGRAPHY; LIQUID PHASE EPITAXY; MAGNETIC RESONANCE; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERCOLATION (SOLID STATE); RESONANCE; SENSITIVITY ANALYSIS; SOLAR RADIATION; SOLVENT EXTRACTION; SULFATE MINERALS;

ADHESIVE TAPES; DEGRADATION PRODUCT; DEGRADATION PRODUCTS; HIGHER CONCENTRATIONS; IDENTIFICATION; LC-MS; LC-NMR; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; LOW SENSITIVITY; LOXOPROFEN SODIUM ADHESIVE TAPE; MASS MEASUREMENTS; MOLECULAR FORMULAE; NMR ANALYSES; PRE-CONCENTRATION; PRESSURIZED LIQUID EXTRACTION; PURIFICATION PROCESSES; SAMPLE PREPARATIONS; SOLID-PHASE EXTRACTION; SPE COLUMN;

EXTRACTION;

CARBOXYLIC ACID; LOXOPROFEN;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; DRUG DEGRADATION; DRUG IDENTIFICATION; DRUG STRUCTURE; HEAT STRESS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONLINE MONITORING; OXIDATION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION;

ADHESIVES; CHROMATOGRAPHY, LIQUID; HOT TEMPERATURE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHENYLPROPIONATES; SOLID PHASE EXTRACTION;

EID: 53049091678     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.08.076     Document Type: Article

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