Application of liquid chromatography-two-dimensional nuclear magnetic resonance spectroscopy using pre-concentration column trapping and liquid chromatography-mass spectrometry for the identification of degradation products in stressed commercial amlodipine maleate tablets

Journal of Chromatography A

Volumn 1181, Issue 1-2, 2008, Pages 67-76

  Murakami, Tomonori ^a   Fukutsu, Naoto ^a   Kondo, Junichi ^a   Kawasaki, Takao ^a   Kusu, Fumiyo ^b  

^a DAIICHI SANKYO CO   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Amlodipine maleate tablet; Degradation product; LC 2D NMR; LC MS

Indexed keywords

AMLODIPINE MALEATE TABLETS; COUPLING CONSTANT; DEGRADATION PRODUCTS; LACTOSE ANOMERIC PROTONS;

DEGRADATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTONS;

DRUG PRODUCTS;

AMLODIPINE; AMLODIPINE MALEATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DEGRADATION; HETERONUCLEAR MULTIPLE BOND COHERENCE SPECTROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SPECTROSCOPY; TWO DIMENSIONAL CORRELATED EFFECT;

AMLODIPINE; CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUG STABILITY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

EID: 38649091965     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.12.038     Document Type: Article

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