Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and bax activation

Journal of Biological Chemistry

Volumn 283, Issue 35, 2008, Pages 23721-23730

  Wilsbacher, Julie L ^a   Zhang, Qian ^a   Tucker, Lora A ^a   Hubbard, Robert D ^a   Sheppard, George S ^a   Bamaung, Nwe Y ^a   Fidanze, Steve D ^a   Wang, Gary T ^a   Hu, Xiaoming ^a   Davidsen, Steven K ^a   Bell, Randy L ^a   Wang, Jieyi ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS; AMINO ACIDS; BIOACTIVITY; CELL DEATH; CELL PROLIFERATION; GROWTH (MATERIALS); GROWTH KINETICS; HORMONES; INSULIN; PEPTIDES; PHOSPHORYLATION;

APOPTOSIS; APOPTOTIC SIGNALING; BAX ACTIVATIONS; CANCER.; COMBINED EFFECTS; EXPRESSION LEVELS; GROWTH FACTORS; IN CELLS; INDUCED APOPTOSIS; INHIBITOR COMBINATIONS; KINASE INHIBITORS; RECEPTOR TYROSINE KINASES; SIGNALING PATHWAYS; SQUAMOUS CELL CARCINOMATA; SYNERGISTIC EFFECTS; XENOGRAFT TUMORS;

CELL GROWTH;

4 AMINO 5 (3 BENZYLOXYPHENYL) 7 [3 (1 PYRROLIDINYLMETHYL)CYCLOBUTYL] 7H PYRROLO[2,3 D]PYRIMIDINE; CELL CYCLE PROTEIN; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; PROTEIN BAX; PROTEIN KINASE B; PROTEIN MCL 1; SOMATOMEDIN C RECEPTOR; BAX PROTEIN, HUMAN; CYCLIN D; CYCLINE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; ANIMAL; CANCER TRANSPLANTATION; CELL SURVIVAL; DRUG ANTAGONISM; DRUG RESISTANCE; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; NEOPLASM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYCLINS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM TRANSPLANTATION; NEOPLASMS; ONCOGENE PROTEINS V-ERBB; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 53049083774     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708360200     Document Type: Article

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