Low expression of APAF-1XL in acute myeloid leukemia may be associated with the failure of remission induction therapy

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 7, 2008, Pages 571-578

  Benites, B D ^a   Fattori, A ^a   Hackel, C ^a   Lorand Metze, I ^a   De Souza, C A ^a   Schulz, E ^a   Costa, F F ^a   Saad, Sara T O ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Acute myeloid leukemia; APAF 1; Apoptosis; Chemotherapy resistance

Indexed keywords

ANTHRACYCLINE DERIVATIVE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; APOPTOTIC PROTEASE ACTIVATING FACTOR 1LC; APOPTOTIC PROTEASE ACTIVATING FACTOR 1LN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1S; APOPTOTIC PROTEASE ACTIVATING FACTOR 1XL; CORE BINDING FACTOR BETA; CYTARABINE; ENZYME ACTIVATOR; ETOPOSIDE; MESSENGER RNA; MITOXANTRONE; MYOSIN HEAVY CHAIN; MYOSIN HEAVY CHAIN 11; PROCASPASE 9; PROMYELOCYTIC LEUKEMIA PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; TIOGUANINE; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BLOOD CELL COUNT; BONE MARROW; CANCER MORTALITY; CANCER RESISTANCE; CLINICAL ARTICLE; CYTOGENETICS; DRUG RESPONSE; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; LEUKEMIA REMISSION; MALE; OVERALL SURVIVAL; PROGNOSIS;

EID: 52949152443     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008000700004     Document Type: Article

References (36)

1. Nicholson DW. ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nat Biotechnol 1996; 14: 297-301.
2. Jia L, Allen PD, Macey MG, Grahn MF, Newland AC, Kelsey SM. Mitochondrial electron transport chain activity, but not ATP synthesis, is required for drug-induced apoptosis in human leukaemic cells: a possible novel mechanism of regulating drug resistance. Br J Haematol 1997; 98: 686-698.
3. Jia L, Macey MG, Yin Y, Newland AC, Kelsey SM. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood 1999; 93: 2353-2359.
4. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
5. Hu Y, Benedict MA, Ding L, Nunez G. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J 1999; 18: 3586-3595.
6. Saleh A, Srinivasula SM, Acharya S, Fishel R, Alnemri ES. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem 1999; 274: 17941-17945.
7. Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 1998; 94: 727-737.
8. Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, et al. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94: 739-750.
9. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997; 90: 405-413.
10. Hahn C, Hirsch B, Jahnke D, Durkop H, Stein H. Three new types of Apaf-1 in mammalian cells. Biochem Biophys Res Commun 1999; 261: 746-749.
11. Walke DW, Morgan JI. A comparison of the expression and properties of Apaf-1 and Apaf-1L. Brain Res 2000; 886: 73-81.
12. Benedict MA, Hu Y, Inohara N, Nunez G. Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9. J Biol Chem 2000; 275: 8461-8468.
13. Melo MB, Ahmad NN, Lima CS, Pagnano KB, Bordin S, Lorand-Metze I, et al. Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis. Hematology 2002; 7: 13-19.
14. Casas S, Ollila J, Aventin A, Vihinen M, Sierra J, Knuutila S. Changes in apoptosis-related pathways in acute myelocytic leukemia. Cancer Genet Cytogenet 2003; 146: 89-101.
15. Svingen PA, Karp JE, Krajewski S, Mesner PW Jr, Gore SD, Burke PJ, et al. Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia. Blood 2000; 96: 3922-3931.
16. Jia L, Srinivasula SM, Liu FT, Newland AC, Fernandes-Alnemri T, Alnemri ES, et al. Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells. Blood 2001; 98: 414-421.
17. Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, Ishii H, et al. Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res 2005; 3: 325-334.
18. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 1985; 103: 620-625.
19. Krzyzanski W, Oberdoester J, Rabin RA. Mechanism of ethanol enhancement of apoptosis and caspase activation in serum-deprived PC12 cells. Life Sci 2007; 81: 756-764.
20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
21. Vandenbroucke II, Vandesompele J, Paepe AD, Messiaen L. Quantification of splice variants using real-time PCR. Nucleic Acids Res 2001; 29: E68.
22. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
23. Tse W, Meshinchi S, Alonzo TA, Stirewalt DL, Gerbing RB, Woods WG, et al. Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemia. Blood 2004; 104: 3058-3063.
24. Recher C, Ysebaert L, Beyne-Rauzy O, Mansat-De Mas V, Ruidavets JB, Cariven P, et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res 2004; 64: 3191-3197.
25. Tourneur L, Delluc S, Levy V, Valensi F, Radford-Weiss I, Legrand O, et al. Absence or low expression of fas-associated protein with death domain in acute myeloid leukemia cells predicts resistance to chemotherapy and poor outcome. Cancer Res 2004; 64: 8101-8108.
26. Del Poeta G, Venditti A, Del Principe MI, Maurillo L, Buccisano F, Tamburini A, et al. Amount of spontaneous apoptosis detected by Bax/ Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML). Blood 2003; 101: 2125-2131.
27. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.
28. Campos L, Rouault JP, Sabido O, Oriol P, Roubi N, Vasselon C, et al. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood 1993; 81: 3091-3096.
29. Lauria F, Raspadori D, Rondelli D, Ventura MA, Fiacchini M, Visani G, et al. High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate. Leukemia 1997; 11: 2075-2078.
30. Bincoletto C, Saad ST, da Silva ES, Queiroz ML. Haematopoietic response and bcl-2 expression in patients with acute myeloid leukaemia. Eur J Haematol 1999; 62: 38-42.
31. Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X, et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001; 409: 207-211.
32. Sun Y, Orrenius S, Pervaiz S, Fadeel B. Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance. Blood 2005; 105: 4070-4077.
33. Sturm I, Bosanquet AG, Radetzki S, Hummel M, Dorken B, Daniel PT. Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation. Int J Cancer 2006; 118: 2329-2336.
34. Umetani N, Fujimoto A, Takeuchi H, Shinozaki M, Bilchik AJ, Hoon DS. Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma. Oncogene 2004; 23: 8292-8300.
35. Leo C, Richter C, Horn LC, Schutz A, Pilch H, Hockel M. Expression of Apaf-1 in cervical cancer correlates with lymph node metastasis but not with intratumoral hypoxia. Gynecol Oncol 2005; 97: 602-606.
36. Roman-Gomez J, Jimenez-Velasco A, Castillejo JA, Agirre X, Barrios M, Navarro G, et al. Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood 2004; 104: 2492-2498.