메뉴 건너뛰기




Volumn 20, Issue 10, 2008, Pages 1351-1360

Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: Implications for peripheral tolerance

Author keywords

Autoimmunity; B cells; Fas; Skin

Indexed keywords

DESMOGLEIN 3; FAS LIGAND; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROTEIN BCL 2; RAG2 PROTEIN;

EID: 52949149409     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn095     Document Type: Article
Times cited : (13)

References (55)
  • 1
    • 0034045874 scopus 로고    scopus 로고
    • Receptor selection in B and T lymphocytes
    • Nemazee, D. 2000. Receptor selection in B and T lymphocytes. Annu. Rev. Immunol. 18:19.
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 19
    • Nemazee, D.1
  • 2
    • 33748992038 scopus 로고    scopus 로고
    • Receptor editing in lymphocyte development and central tolerance
    • Nemazee, D. 2006. Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6:728.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 728
    • Nemazee, D.1
  • 3
    • 0032494194 scopus 로고    scopus 로고
    • Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes
    • Kench, J. A., Russell, D. M. and Nemazee, D. 1998. Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes. J. Exp. Med. 188:909.
    • (1998) J. Exp. Med , vol.188 , pp. 909
    • Kench, J.A.1    Russell, D.M.2    Nemazee, D.3
  • 4
    • 0029076561 scopus 로고
    • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells
    • Rathmell, J. C., Cooke, M. P., Ho, W. Y. et al. 1995. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 376:181.
    • (1995) Nature , vol.376 , pp. 181
    • Rathmell, J.C.1    Cooke, M.P.2    Ho, W.Y.3
  • 5
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. and Nagata, S. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
    • (1992) Nature , vol.356 , pp. 314
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 6
    • 0026471742 scopus 로고
    • Genetic analysis of MRL-lpr mice: Relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci
    • Watson, M. L., Rao, J. K., Gilkeson, G. S. et al. 1992. Genetic analysis of MRL-lpr mice: Relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176:1645.
    • (1992) J. Exp. Med , vol.176 , pp. 1645
    • Watson, M.L.1    Rao, J.K.2    Gilkeson, G.S.3
  • 7
    • 0037730377 scopus 로고    scopus 로고
    • FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease
    • Yajima, K., Nakamura, A., Sugahara, A. and Takai, T. 2003. FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur. J. Immunol. 33:1020.
    • (2003) Eur. J. Immunol , vol.33 , pp. 1020
    • Yajima, K.1    Nakamura, A.2    Sugahara, A.3    Takai, T.4
  • 8
    • 0025789652 scopus 로고
    • Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
    • Amagai, M., Klaus-Kovtun, V. and Stanley, J. R. 1991. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67:869.
    • (1991) Cell , vol.67 , pp. 869
    • Amagai, M.1    Klaus-Kovtun, V.2    Stanley, J.R.3
  • 9
    • 0025804398 scopus 로고
    • Major Histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris
    • Ahmed, A. R., Wagner, R., Khatri, K. et al. 1991. Major Histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc. Natl Acad. Sci. USA 88:5056.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 5056
    • Ahmed, A.R.1    Wagner, R.2    Khatri, K.3
  • 10
    • 0027984822 scopus 로고
    • HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method
    • Niizeki, H., Inoko, H., Mizuki, N. et al. 1994. HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method. Tissue Antigens 44:248.
    • (1994) Tissue Antigens , vol.44 , pp. 248
    • Niizeki, H.1    Inoko, H.2    Mizuki, N.3
  • 11
    • 0025739256 scopus 로고
    • HLA class II antigens are associated with Japanese pemphigus patients
    • Niizeki, H., Inoko, H., Narimatsu, H. et al. 1991. HLA class II antigens are associated with Japanese pemphigus patients. Hum. Immunol. 31:246.
    • (1991) Hum. Immunol , vol.31 , pp. 246
    • Niizeki, H.1    Inoko, H.2    Narimatsu, H.3
  • 12
    • 20144387052 scopus 로고    scopus 로고
    • Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display
    • Payne, A. S., Ishii, K., Kacir, S. et al. 2005. Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J. Clin. Invest. 115:888.
    • (2005) J. Clin. Invest , vol.115 , pp. 888
    • Payne, A.S.1    Ishii, K.2    Kacir, S.3
  • 13
    • 0033731491 scopus 로고    scopus 로고
    • Conformational eptiope mapping of desmoglein 3 using domain-swapped molecules in pemphigus vulgaris
    • Futei, Y., Amagai, M., Sekiguchi, M., Nishifuji, K., Fujii, Y. and Nishikawa, T. 2000. Conformational eptiope mapping of desmoglein 3 using domain-swapped molecules in pemphigus vulgaris. J. Invest. Dermatol. 115:829.
    • (2000) J. Invest. Dermatol , vol.115 , pp. 829
    • Futei, Y.1    Amagai, M.2    Sekiguchi, M.3    Nishifuji, K.4    Fujii, Y.5    Nishikawa, T.6
  • 14
    • 0035500301 scopus 로고    scopus 로고
    • Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins
    • Sekiguchi, M., Futei, Y., Fujii, Y., Iwasaki, T., Nishikawa, T. and Amagai, M. 2001. Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins. J. Immunol. 167:5439.
    • (2001) J. Immunol , vol.167 , pp. 5439
    • Sekiguchi, M.1    Futei, Y.2    Fujii, Y.3    Iwasaki, T.4    Nishikawa, T.5    Amagai, M.6
  • 15
    • 0034116198 scopus 로고    scopus 로고
    • Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus
    • Amagai, M., Tsunoda, K., Suzuki, H., Nishifuji, K., Koyasu, S. and Nishikawa, T. 2000. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J. Clin. Invest. 105:625.
    • (2000) J. Clin. Invest , vol.105 , pp. 625
    • Amagai, M.1    Tsunoda, K.2    Suzuki, H.3    Nishifuji, K.4    Koyasu, S.5    Nishikawa, T.6
  • 16
    • 3242762566 scopus 로고    scopus 로고
    • A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice
    • Aoki-Ota, M., Tsunoda, K., Ota, T. et al. 2004. A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice. Br. J. Dermatol. 151:346.
    • (2004) Br. J. Dermatol , vol.151 , pp. 346
    • Aoki-Ota, M.1    Tsunoda, K.2    Ota, T.3
  • 17
    • 0036209714 scopus 로고    scopus 로고
    • Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris
    • Tsunoda, K., Ota, T., Suzuki, H. et al. 2002. Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris. Eur. J. Immunol. 32:627.
    • (2002) Eur. J. Immunol , vol.32 , pp. 627
    • Tsunoda, K.1    Ota, T.2    Suzuki, H.3
  • 18
    • 33751103915 scopus 로고    scopus 로고
    • Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation
    • Kawasaki, H., Tsunoda, K., Hata, T., Ishii, K., Yamada, T. and Amagai, M. 2006. Synergistic pathogenic effects of combined mouse monoclonal anti-desmoglein 3 IgG antibodies on pemphigus vulgaris blister formation. J. Invest. Dermatol. 126:2621.
    • (2006) J. Invest. Dermatol , vol.126 , pp. 2621
    • Kawasaki, H.1    Tsunoda, K.2    Hata, T.3    Ishii, K.4    Yamada, T.5    Amagai, M.6
  • 19
    • 0037442123 scopus 로고    scopus 로고
    • Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive Interface of desmoglein 3
    • Tsunoda, K., Ota, T., Aoki, M. et al. 2003. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive Interface of desmoglein 3. J. Immunol. 170: 2170.
    • (2003) J. Immunol , vol.170 , pp. 2170
    • Tsunoda, K.1    Ota, T.2    Aoki, M.3
  • 20
    • 5044252860 scopus 로고    scopus 로고
    • Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism
    • Ota, T., Aoki-Ota, M., Tsunoda, K. et al. 2004. Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism. Int. Immunol. 16:1487.
    • (2004) Int. Immunol , vol.16 , pp. 1487
    • Ota, T.1    Aoki-Ota, M.2    Tsunoda, K.3
  • 21
    • 0030902370 scopus 로고    scopus 로고
    • Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
    • Koch, P. J., Mahoney, M. G., Ishikawa, H. et al. 1997. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J. Cell Biol. 137:1091.
    • (1997) J. Cell Biol , vol.137 , pp. 1091
    • Koch, P.J.1    Mahoney, M.G.2    Ishikawa, H.3
  • 22
    • 0026581936 scopus 로고
    • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    • Shinkai, Y., Rathbun, G., Lam, K. P. et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
    • (1992) Cell , vol.68 , pp. 855
    • Shinkai, Y.1    Rathbun, G.2    Lam, K.P.3
  • 23
    • 27544458293 scopus 로고    scopus 로고
    • Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling
    • Gauld, S. B., Benschop, R. J., Merrell, K. T. and Cambier, J. C. 2005. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat. Immunol. 6: 1160.
    • (2005) Nat. Immunol , vol.6 , pp. 1160
    • Gauld, S.B.1    Benschop, R.J.2    Merrell, K.T.3    Cambier, J.C.4
  • 24
    • 33845398322 scopus 로고    scopus 로고
    • Identification of anergic B cells within a wild-type repertoire
    • Merrell, K. T., Benschop, R. J., Gauld, S. B. et al. 2006. Identification of anergic B cells within a wild-type repertoire. Immunity 25:953.
    • (2006) Immunity , vol.25 , pp. 953
    • Merrell, K.T.1    Benschop, R.J.2    Gauld, S.B.3
  • 25
    • 0031897801 scopus 로고    scopus 로고
    • Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
    • Barnden, M. J., Allison, J., Heath, W. R. and Carbone, F. R. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76:34.
    • (1998) Immunol. Cell Biol , vol.76 , pp. 34
    • Barnden, M.J.1    Allison, J.2    Heath, W.R.3    Carbone, F.R.4
  • 26
    • 0035099037 scopus 로고    scopus 로고
    • Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire
    • Takahashi, Y., Ohta, H. and Takemori, T. 2001. Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire. Immunity 14:181.
    • (2001) Immunity , vol.14 , pp. 181
    • Takahashi, Y.1    Ohta, H.2    Takemori, T.3
  • 27
    • 0028429962 scopus 로고
    • The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
    • Lynch, D. H., Watson, M. L., Alderson, M. R. et al. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1: 131.
    • (1994) Immunity , vol.1 , pp. 131
    • Lynch, D.H.1    Watson, M.L.2    Alderson, M.R.3
  • 28
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • Takahashi, T., Tanaka, M., Brannan, C. I. et al. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969.
    • (1994) Cell , vol.76 , pp. 969
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3
  • 29
    • 34247120690 scopus 로고    scopus 로고
    • Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4-Tregs, regulate effector T cells using FasL
    • Baatar, D., Olkhanud, P., Sumitomo, K., Taub, D., Gress, R. and Biragyn, A. 2007. Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4-Tregs, regulate effector T cells using FasL. J. Immunol. 178:4891.
    • (2007) J. Immunol , vol.178 , pp. 4891
    • Baatar, D.1    Olkhanud, P.2    Sumitomo, K.3    Taub, D.4    Gress, R.5    Biragyn, A.6
  • 30
    • 33750306678 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism
    • Venet, F., Pachot, A., Debard, A. L. et al. 2006. Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J. Immunol. 177:6540.
    • (2006) J. Immunol , vol.177 , pp. 6540
    • Venet, F.1    Pachot, A.2    Debard, A.L.3
  • 31
    • 0028915454 scopus 로고
    • Regulation of lymphocyte survival by the bcl-2 gene family
    • Cory, S. 1995. Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13:513.
    • (1995) Annu. Rev. Immunol , vol.13 , pp. 513
    • Cory, S.1
  • 32
    • 0026468231 scopus 로고
    • Differential effects of Bcl-2 on T and B cells in transgenic mice
    • Katsumata, M., Siegel, R. M., Louie, D. C. et al. 1992. Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc. Natl Acad. Sci. USA 89:11376.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 11376
    • Katsumata, M.1    Siegel, R.M.2    Louie, D.C.3
  • 33
    • 0030694311 scopus 로고    scopus 로고
    • Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells
    • Lang, J., Arnold, B., Hammerling, G. et al. 1997. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J. Exp. Med. 186:1513.
    • (1997) J. Exp. Med , vol.186 , pp. 1513
    • Lang, J.1    Arnold, B.2    Hammerling, G.3
  • 34
    • 0028297141 scopus 로고
    • Bcl-2 expression promotes B- but not T-lymphoid development in scid mice
    • Strasser, A., Harris, A. W., Corcoran, L. M. and Cory, S. 1994. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 368:457.
    • (1994) Nature , vol.368 , pp. 457
    • Strasser, A.1    Harris, A.W.2    Corcoran, L.M.3    Cory, S.4
  • 35
    • 0025939204 scopus 로고
    • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser, A., Whittingham, S., Vaux, D. L. et al. 1991. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl Acad. Sci. USA 88:8661.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 8661
    • Strasser, A.1    Whittingham, S.2    Vaux, D.L.3
  • 36
    • 0037868066 scopus 로고    scopus 로고
    • Selective unresponsiveness to conformational B cell epitopes of the myelin oligodendrocyte glycoprotein in H-2b mice
    • Bourquin, C., Schubart, A., Tobollik, S. et al. 2003. Selective unresponsiveness to conformational B cell epitopes of the myelin oligodendrocyte glycoprotein in H-2b mice. J. Immunol. 171:455.
    • (2003) J. Immunol , vol.171 , pp. 455
    • Bourquin, C.1    Schubart, A.2    Tobollik, S.3
  • 37
    • 0034612560 scopus 로고    scopus 로고
    • The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research
    • Warren, S. J., Lin, M. S., Giudice, G. J. et al. 2000. The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research. N. Engl. J. Med. 343:23.
    • (2000) N. Engl. J. Med , vol.343 , pp. 23
    • Warren, S.J.1    Lin, M.S.2    Giudice, G.J.3
  • 38
    • 0031468121 scopus 로고    scopus 로고
    • Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells
    • Akkaraju, S., Canaan, K. and Goodnow, C. C. 1997. Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells. J. Exp. Med. 186:2005.
    • (1997) J. Exp. Med , vol.186
    • Akkaraju, S.1    Canaan, K.2    Goodnow, C.C.3
  • 39
    • 0025017688 scopus 로고
    • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
    • Shlomchik, M., Mascelli, M., Shan, H. et al. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265.
    • (1990) J. Exp. Med , vol.171 , pp. 265
    • Shlomchik, M.1    Mascelli, M.2    Shan, H.3
  • 43
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. and von Boehmer, H. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756.
    • (2002) Nat. Immunol , vol.3 , pp. 756
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 44
    • 0035320679 scopus 로고    scopus 로고
    • Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    • Jordan, M. S., Boesteanu, A., Reed, A. J. et al. 2001. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
    • (2001) Nat. Immunol , vol.2 , pp. 301
    • Jordan, M.S.1    Boesteanu, A.2    Reed, A.J.3
  • 46
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen, H. M.. Benoist, C. and Mathis, D. 2004. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200: 1221.
    • (2004) J. Exp. Med , vol.200 , pp. 1221
    • van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 47
    • 13544271161 scopus 로고    scopus 로고
    • Cutting edge: Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    • Gondek, D. C., Lu, L. F., Quezada, S. A., Sakaguchi, S. and Noelle, R. J. 2005. Cutting edge: Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 174:1783.
    • (2005) J. Immunol , vol.174 , pp. 1783
    • Gondek, D.C.1    Lu, L.F.2    Quezada, S.A.3    Sakaguchi, S.4    Noelle, R.J.5
  • 48
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • Grossman, W. J., Verbsky, J. W., Barchet, W., Colonna, M., Atkinson, J. P. and Ley, T. J. 2004. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21:589.
    • (2004) Immunity , vol.21 , pp. 589
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 49
    • 5644238762 scopus 로고    scopus 로고
    • Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
    • Grossman, W. J., Verbsky, J. W., Tollefsen, B. L., Kemper, C., Atkinson, J. P. and Ley, T. J. 2004. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104:2840.
    • (2004) Blood , vol.104 , pp. 2840
    • Grossman, W.J.1    Verbsky, J.W.2    Tollefsen, B.L.3    Kemper, C.4    Atkinson, J.P.5    Ley, T.J.6
  • 51
    • 33646567156 scopus 로고    scopus 로고
    • Activated CD4+CD25+ T cells selectively kill B lymphocytes
    • Zhao, D. M., Thornton, A. M., DiPaolo, R. J. and Shevach, E. M. 2006. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107:3925.
    • (2006) Blood , vol.107 , pp. 3925
    • Zhao, D.M.1    Thornton, A.M.2    DiPaolo, R.J.3    Shevach, E.M.4
  • 52
    • 1542619242 scopus 로고    scopus 로고
    • T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals
    • Veldman, C. M., Gebhard, K. L., Uter, W. et al. 2004. T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals. J. Immunol. 172:3883.
    • (2004) J. Immunol , vol.172 , pp. 3883
    • Veldman, C.M.1    Gebhard, K.L.2    Uter, W.3
  • 53
    • 2442535915 scopus 로고    scopus 로고
    • Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris
    • Veldman, C., Hohne, A., Dieckmann, D., Schuler, G. and Herti, M. 2004. Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgaris. J. Immunol. 172:6468.
    • (2004) J. Immunol , vol.172 , pp. 6468
    • Veldman, C.1    Hohne, A.2    Dieckmann, D.3    Schuler, G.4    Herti, M.5
  • 54
    • 23944443477 scopus 로고    scopus 로고
    • Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: Effect of immunosuppressive treatment
    • Fattorossi, A., Battaglia, A., Buzzonetti, A., Ciaraffa, F., Scambia, G. and Evoli, A. 2005. Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: Effect of immunosuppressive treatment. Immunology 116:134.
    • (2005) Immunology , vol.116 , pp. 134
    • Fattorossi, A.1    Battaglia, A.2    Buzzonetti, A.3    Ciaraffa, F.4    Scambia, G.5    Evoli, A.6
  • 55
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • Balandina, A., Lecart, S., Dartevelle, P., Saoudi, A. and Berrih-Aknin, S. 2005. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 105:735.
    • (2005) Blood , vol.105 , pp. 735
    • Balandina, A.1    Lecart, S.2    Dartevelle, P.3    Saoudi, A.4    Berrih-Aknin, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.