Forensic pathological investigation of myocardial hypoxia-inducible factor-1α, erythropoietin and vascular endothelial growth factor in cardiac death

Legal Medicine

Volumn 10, Issue 1, 2008, Pages 11-19

  Zhu, Bao Li ^a,b   Tanaka, Sayaka ^a,c   Ishikawa, Takaki ^a,c   Zhao, Dong ^a   Li, Dong Ri ^a   Michiue, Tomomi ^a,c   Quan, Li ^a,c   Maeda, Hitoshi ^a,c  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c Osaka Medical Examiner's Office   (Japan)

Author keywords

Cardiac death; Forensic pathology; Hypoxia response factor; Immunohistochemistry; Myocardial ischemia; RT PCR

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; ASPHYXIA; AUTOPSY; CAUSE OF DEATH; CELL DAMAGE; CELL STRUCTURE; CHRONIC DISEASE; CONGESTIVE CARDIOMYOPATHY; DISEASE DURATION; DISEASE SEVERITY; DOWNSTREAM PROCESSING; DROWNING; FEMALE; FORENSIC PATHOLOGY; HEART DEATH; HEART DISEASE; HEART INFARCTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART STRESS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MEDICOLEGAL ASPECT; NECROSIS; RECURRENT DISEASE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLING; SUDDEN DEATH; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DEATH, SUDDEN, CARDIAC; ERYTHROPOIETIN; FEMALE; FORENSIC PATHOLOGY; HEART FAILURE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 36448988946     PISSN: 13446223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.legalmed.2007.06.002     Document Type: Article

References (29)

1. Lu M.J., Chang H., Chang C.C., Wang B.W., and Shyu K.G. Temporal and spatial expression of hypoxia-inducible factor-α and vascular endothelial growth factor in a rat model of myocardial ischemia with or without reperfusion. J Formos Med Assoc 104 (2005) 707-714
2. Liu L.X., Lu H., Luo Y., Date T., Belanger A.J., Vincent K.A., et al. Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1. Biochem Biophys Res Commun 291 (2002) 908-914
3. Hashimoto E., Ogita T., Nakaoka T., Matsuoka R., Takao A., and Kira Y. Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am J Physiol 267 (1994) H1948-H1954
4. Maloyan A., Eli-Berchoer L., Semenza G.L., Gerstenblith G., Stern M.D., and Horowitz M. HIF-1α-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiol Genomics 23 (2005) 79-88
5. Shyu K.G., Liou J.Y., Wang B.W., Fang W.J., and Chang H. Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1α and vascular endothelial growth factor in pressure-overloaded rat heart. J Biomed Sci 12 (2005) 409-420
6. Martin C., Yu A.Y., Jiang B.H., Davis L., Kimberly D., Hohimer A.R., et al. Cardiac hypertrophy in chronically anemic fatal sheep: increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am J Obstet Gynecol 178 (1998) 527-534
7. Kido M., Du L., Sullivan C.C., Li X., Deutsch R., Jamieson S.W., et al. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 46 (2005) 2116-2124
8. Sasso F.C., Torella D., Carbonara O., Ellson G.M., Torella M., Scardone M., et al. Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease. J Am Coll Cardiol 46 (2005) 827-834
9. Lee S.H., Wolf P.L., Escudero R., Deutsh R., Jamieson S.W., and Thistlethwaite P.A. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med 342 (2000) 626-633
10. Marfella R., Esposito K., Nappo F., Siniscalchi M., Sasso F.C., Protoghese M., et al. Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes. Diabetes 53 (2004) 2383-2391
11. Xu X., Li J., Simons M., Li J., Laham R.J., and Sellke F.W. Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia. J Thorac Cardiovasc Surg 121 (2001) 735-742
12. Pampin J.B., Rivero S.A.G., Cepeda X.L.O., Boquete A.V., Vila J.F., and Fonseca R.H. Immunohistochemical expression of HIF-1α in response to early myocardial ischemia. J Forensic Sci 51 (2006) 120-124
13. Zhu B.L., Ishikawa T., Michiue T., Li D.R., Zhao D., Oritani S., et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1: analysis with special regard to traumatic causes of death. Legal Med 8 (2006) 86-93
14. Zhu B.L., Ishikawa T., Michiue T., Li D.R., Zhao D., Kamikodai Y., et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 2: analysis for application in the diagnosis of sudden cardiac death with regard to pathology. Legal Med 8 (2006) 94-101
15. Zhao D., Zhu B.L., Ishikawa T., Quan L., Li D.R., and Maeda H. Real-time RT-PCR quantitative assays and postmortem degradation profiles or erythropoietin, vascular endothelial growth factor and hypoxia-inducible factor 1 alpha mRNA transcripts in forensic autopsy materials. Legal Med 8 (2006) 132-136
16. Zhao D., Zhu B.L., Ishikawa T., Li D.R., Michiue T., and Maeda H. Quantitative RT-PCR assays of hypoxia-inducible factor -1α, erythropoietin and vascular endothelial growth factor mRNA transcripts in the kidneys with regard to the cause of death in medicolegal autopsy. Legal Med 8 (2006) 258-263
17. Ishida K., Zhu B.L., and Maeda H. Novel approach to quantitative reverse transcription PCR assay of mRNA component in autopsy materials using the taqman fluorogenic detection system: dynamics of pulmonary surfactant apoprotein A. Forensic Sci Int 113 (2000) 127-131
18. Yuan A., Yu C.J., Luh K.T., Chen W.J., Lin F.Y., Kuo S.H., et al. Quantification of VEGF mRNA expression in non-small cell lung cancer using a real-time quantitative reverse transcription-PCR assay and a comparison with quantitative competitive reverse transcription-PCR. Lab Invest 80 (2000) 1671-1680
19. Yokomizo R., Matsuzaki S., Uehara S., Murakami T., Yaegashi N., and Okamura K. Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle. Mol Hum Reprod 8 (2002) 441-446
20. Tsutamoto T., Wada A., Maeda K., Hisanaga T., Maeda Y., Fukai D., et al. Attenuation of compression of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation 96 (1997) 509-516
21. Katus H.A., Remppis A., Neumann F.J., Scheffold T., Diederich K.W., Vinar G., et al. Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation 83 (1991) 902-912
22. Baum H., Braun S., Gerhardt W., Gilson G., Hafner G., Muller-Bardorff M., et al. Multicenter evalution of a second-generation assay for cardiac troponin T. Clin Chem 43 (1997) 1877-1884
23. Zweig M.H., and Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39 (1993) 561-577
24. Beck J.R., and Shultz E.K. The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110 (1986) 13-20
25. Ishikawa Y., Komiyama K., Masuda S., Murakami M., Akasaka Y., Ito K., et al. Expression of type V secretory phosholipase A2 in myocardial remodeling after infarction. Histopathology 47 (2005) 257-267
26. Myerburg R.J. Sudden cardiac death: epidemiology, causes, and mechanisms. Cardiology 74 (1987) S2-S9
27. Podrid P.J., and Myerburg R.J. Epidemiology and stratification of risk for sudden cardiac death. Clin Cardiol 28 (2005) S3-S11
28. Zhu B.L., Ishikawa T., Michiue T., Li D.R., Zhao D., Tanaka S., et al. Postmortem pericardial natriuretic peptides as markers of cardiac function in medico-legal autopsies. Int J Legal Med 121 (2007) 28-35
29. Zhu B.L., Ishida K., Taniguchi M., Quan L., Oritani S., Tsuda K., et al. Possible postmortem serum markers for differentiation between fresh-, saltwater drowning and acute cardiac death: a preliminary investigation. Legal Med 5 (2003) S298-S301