Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1α induced for impaired myocardial energy metabolism

Circulation

Volumn 103, Issue 19, 2001, Pages 2387-2394

  Kakinuma, Yoshihiko ^a   Miyauchi, Takashi ^a,b   Yuki, Koichi ^a   Murakoshi, Nobuyuki ^a   Goto, Katsutoshi ^b   Yamaguchi, Iwao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Endothelin; Genes; Heart failure; Metabolism

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1; LUCIFERASE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CARDIOMYOPATHY; CONTROLLED STUDY; DNA BINDING; ELECTROPHORETIC MOBILITY; ENERGY METABOLISM; FATTY ACID OXIDATION; GENE EXPRESSION; HAMSTER; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION REGULATION;

EID: 0035873888     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.19.2387     Document Type: Article

References (24)

1. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol. 1999;61:391-415.
2. Yanagisawa M, Kurihara H, Kimura H, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332: 411-415.
3. Miyauchi T, Yorikane R, Sakai S, et al. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res. 1993;73: 887-897.
4. Sakai S, Miyauchi T, Sakurai T, et al. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure: marked increase in endothelin-1 production in the failing heart. Circulation. 1996;93:1214-1222.
5. Sakai S, Miyauchi T, Kobayashi M, et al. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature. 1996;384:353-355.
6. Yamauchi-Kohno R, Miyauchi T, Hoshino T, et al. Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: increase in endothelin-1 production in the heart and beneficial effect of endothelin A antagonist on survival and cardiac function. Circulation. 1999;99: 2171-2176.
7. Spinale FG, Walker JD, Mukherjee R, et al. Concomitant endothelin receptor subtype-A blockade during the progression of pacing-induced congestive heart failure in rabbits: beneficial effects on left ventricular and myocyte function. Circulation. 1997;95:1918-1929.
8. Sack MN, Rader TA, Park S, et al. Fatty acid oxidization enzyme gene expression is downregulated in the failing heart. Circulation. 1996;94: 2837-2842.
9. Recchia FA, McConnell PI, Bernstein RD, et al. Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog. Circ Res. 1998;83:969-979.
10. Semenza GL, Roth PH, Fang HM, et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem. 1994;269:23757-23763.
11. Semenza GL. Transcriptional regulation by hypoxia-inducible factor I. Trends Cardiovasc Med. 1996;6:151-157.
12. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA. 1993;90:4304-4308.
13. Semenza GL. Regulation of erythropoietin production: new insights into molecular mechanisms of oxygen homeostasis. Hematol Oncol Clin N Am. 1994;8:P863-P884.
14. Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996;16:4604-4613.
15. Haleen SJ, Weishaar RE, Overhiser RW, et al. Effects of quinapril, a new angiotensin converting enzyme inhibitor, on left ventricular failure and survival in the cardiomyopathic hamster. Circ Res. 1991; 68:1302-1312.
16. Kakinuma Y, Miyauchi T, Kobayashi T, et al. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Life Sci. 1999;65:1671-1683.
17. Ramsay RR, Singer TP. Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoreductase by rotenone, piericidin A, and MPP+. Biochem Biophys Res Commun. 1992;189:47-52.
18. Weiberg GS. The effect of cobalt ions on energy metabolism in the rat. Can J Biochem Physiol. 1968;46:549-554.
19. Kakinuma Y, Miyauchi T, Yuki K, et al. Mitochondrial dysfunction of cardiomyocytes causing an impairment of cellular energy metabolism induces apoptosis, which is accompanied by an increase in cardiac ET-1 expression. J Cardiovasc Pharmacol. 2000;36:S201-S204.
20. Weiqiong LW, Markovich R, Chen JW, et al. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circ Res. 1998; 83:516-522.
21. Wenger RH, Rolfs A, Marti HH, et al. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α. Biochem Biophys Res Commun. 1996;223:54-59.
22. Schreiber E, Matthias P, Muller MM, et al. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 1989;17:6419.
23. Packer M, Caspi A, Charlon V, et al. Multicenter, double blind, placebocontrolled study on long term endothelin blockade with bosentan in chronic heart failure: results of the REACH-1 trial. Circulation. 1998; 98(suppl I):I-3. Abstract.
24. Sutsch S, Kiowski W, Yan XW, et al. Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure. Circulation. 1998;98: 2262-2268.