Delivery of nanoparticles to the brain detected by fluorescence microscopy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 627-632

  Reimold, Isolde ^a   Domke, Diana ^b   Bender, Joe ^b   Seyfried, Christoph A ^b   Radunz, Hans Eckhard ^b   Fricker, Gert ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NanoDel Technologies GmbH   (Germany)

Author keywords

Blood brain barrier; Drug delivery; Poly(n butylcyano acrylate) (PBCA) nanoparticles

Indexed keywords

CYANOACRYLATE DERIVATIVE; DEXTRAN; DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE; NANOPARTICLE; POLY(N BUTYLCYANO ACRYLATE); RHODAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BRAIN LEVEL; FLUORESCENCE MICROSCOPY; LIGHT SCATTERING; MALE; MICROEMULSION; NONHUMAN; PARTICLE SIZE; RAT; TISSUE DISTRIBUTION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; DEXTRANS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENBUCRILATE; FLUORESCEIN-5-ISOTHIOCYANATE; MALE; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; RATS; RATS, WISTAR; RHODAMINE 123;

EID: 52949107192     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.007     Document Type: Article

References (17)

1. Bauer B., Hartz A.M., Fricker G., and Miller D.S. Modulation of p-glycoprotein transport function at the blood-brain barrier. Exp. Biol. Med. (Maywood) 230 (2005) 118-127
2. Scherrmann J.M. Expression and function of multidrug resistance transporters at the blood-brain barriers. Exp. Opin. Drug Metab. Toxicol. 1 (2005) 233-246
3. Hermann D.M., Kilic E., Spudich A., Krämer S.D., Wunderli-Allenspach H., and Bassetti C.L. Role of drug efflux carriers in the healthy and diseased brain. Ann. Neurol. 60 (2006) 489-498
4. Bodor N., Farag H.H., Barros M.D., Wu W.M., and Buchwald P. In vitro and in vivo evaluations of dihydroquinoline- and dihydroisoquinoline-based targetor moieties for brain-specific chemical delivery systems. J. Drug Target. 10 (2002) 63-71
5. Prokai L., Prokai-Tatrai K., and Bodor N. Targeting drugs to the brain by redox chemical delivery systems. Med. Res. Rev. 20 (2000) 367-416
6. Schneider A., and Huwyler J. Drug transport to brain with targeted liposomes. NeuroRx 2 (2005) 99-107
7. Thöle M M., Nobmann S., Huwyler J., Bartmann A., and Fricker G. Uptake of cationzied albumin coupled liposomes by cultured porcine brain microvessel endothelial cells and intact brain capillaries. J. Drug Target. 10 (2002) 337-344
8. Koziara J.M., Lockman P.R., Allen D.D., and Mumper R.J. Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Contr. Rel. 99 (2004) 259-269
9. Steiniger S.C., Kreuter J., Khalansky A.S., Skidan I.N., Bobruskin A.I., Smirnova Z.S., Severin S.E., Uhl R., Kock M., Geiger K.D., and Gelperina S.E. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int. J. Cancer 109 (2004) 759-767
10. Ambruosi A., Gelperina S., Khalansky A., Tanski S., Theisen A., and Kreuter J. Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model. J. Microencapsul. 23 (2006) 582-592
11. Kreuter J., Hekmatara T., Dreis S., Vogel T., Gelperina S., and Langer K. Covalent attachment of apolipoprotein A-I and Apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain. J. Drug Rel. 118 (2007) 54-58
12. Gessner A., Olbrich C., Schröder W., Kayser O., and Müller R.H. The role of plasma proteins in brain targeting: species dependent protein adsorption patterns on brain-specific lipid drug conjugate (LDC) nanoparticles. Int. J. Pharm. 214 (2001) 87-91
13. Woodcock D.M., Linsenmeyer M.E., Chrojnowski G., Kriegler A.B., Nink V., Webster L.K., and Sayer W.H. Reversal of multidrug resistance by surfactants. Br. J. Cancer 66 (1992) 62-68
14. Nerurkar M.M., Burto P.S., and Borchardt R.T. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarisized efflux system. Pharm. Res. 123 (1996) 528-534
15. Kozler P., and Pokorný J. Evans blue distribution in the rat brain after intracarotid injection with the blood-brain barrier intact and open to osmosis. Sb Lek. 104 (2003) 255-262
16. Tosi G., Costantino L., Ruozi B., Forni F., and Vandelli M.A. Polymeric nanoparticles for the drug delivery to the central nervous system. Exp. Opin. Drug Deliv. 5 (2008) 155-174
17. Kreuter J., Shamenkov D., Petrov V., Ramge P., Cychutek K., Koch-Brandt C., and Alyautdin R. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J. Drug Target. 10 (2002) 317-325