Genotoxic effect of Physalis angulata L. (Solanaceae) extract on human lymphocytes treated in vitro

Biocell

Volumn 32, Issue 2, 2008, Pages 195-200

  dos Santos, Raquel Alves ^a   Cabral, Teresinha Rosa ^b   Cabral, Isabel Rosa ^b   Greggi Antunes, Lusânia Maria ^a,c   Andrade, Cristiane Pontes ^c   dos Santos Cardoso, Plínio Cerqueira ^a   de Oliveira Bahia, Marcelo ^b   Pessoa, Claudia ^d   Martins do Nascimento, José Luis ^b   Burbano, Rommel Rodríguez ^b   Takahashi, Catarina Satie ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^c FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Comet assay; Micronuclei; P. angulata

Indexed keywords

PHYSALIS ANGULATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINESIS; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE CULTURE; LYMPHOCYTOTOXICITY; MICRONUCLEUS TEST; MITOSIS INDEX; MITOSIS INHIBITION; PHYSALIS; PHYSALIS ANGULATA;

ADOLESCENT; ADULT; CELLS, CULTURED; COMET ASSAY; FEMALE; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEUS TESTS; MUTAGENS; PHYSALIS; PLANT EXTRACTS;

PHYSALIS ANGULATA; SOLANACEAE;

EID: 52949095697     PISSN: 03279545     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Aruoma OI (2003). Methodological considerations for characterizing potential antioxidant actions of bioactive components in plant foods. Mutat Res 523: 9-20.
2. Bailar JC, Mosteller F (1992). Medical uses of statistics. Boston, MA: New England Journal Medicine Books, 1992.
3. Canalle R, Burim RV, Callegari JL, Takahashi CS (2001). Assesment of the cytotoxic and clastogenic activities of the sesquiterpene lactone lynchnopholide in mammalian cells in vitro and in vivo. Cancer Detec Prev 25: 93-101.
4. Chiang HC, Jaw SM, Chen CF, Kan WS (1992a). Antitumor agent, physalin F from Physalis angulata L. Anticancer Res 12: 837-843.
5. Chiang HC, Jaw SM, Chen CF (1992). Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro. Anticancer Res 12: 155-162.
6. Choi EM, Hwang JK (2003). Investigations of anti-inflammatory and antinociceptive activities of Piper cubeta, Physalis angulata and Rosa hybrida. J Ethnopharm 89: 171-175.
7. Fenech M (1997). The advantages and disavantages of the cytokinesis-block micronucleus method. Mutat Res 392: 11-18.
8. Fenech M (2000). The in vitro micronucleus technique. Mutat Res 455: 81-95.
9. Fenech M, Crott JW (2002). Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat Res 504: 131-136.
10. Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E; HUman Micron Nucleus project (2003). HUMN project detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated lymphocytes cultures Mutat Res 534: 65-75.
11. Gontijo AMMC, Tice R (2003). Comet Assay: detection of DNA damage and DNA repair in individual cells (Teste do cometa para a deteção de dano no DNA e reparo em células individualizadas). In: Mutagênese Ambiental, Canoas, ULBRA, Ribeiro LR, Salvadori DMF, Marques EK, Eds. pp. 247-275.
12. Hsieh WT, Huang KY, Lin HY, Chung JG (2006). Physalis angulata induced G2/M phase arrest in human breast cancer cells. Food Chem Toxicol 44: 974-983.
13. Islaih M, Halstead BW Kadura IA, Li B, Reid-Hubbard JL, Flick L, Altizer JL, Thom Deahl J, Monteith DK, Newton RK, Watson DE (2005). Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals. Mutat Res 578: 100-116.
14. Ismail N, Alam M (2001). A novel cytotoxic falvonoid glycoside from Physalis angulata. Fitoterapia 72: 676-679.
15. Januário AH, Filho ER, Pietro RC, Kashima S, Sato DN, França SC (2002). Antimycobacterial physalins from Physalis angulata L. (Solanaceae). Phytother Res 16: 445-448.
16. Kuo PC, Kuo TH, Damu AG, Su CR, Lee EJ, Wu TS, Shu R, Chen CM, Bastow KF, Chen TH, Lee KH (2006). Physanolide A, a novel skeleton steroid, and other cytotoxic principles ftom Physalis angulata. Org Lett 8: 2953-2956.
17. Lin YS, Chiang HC, Kan WS, Hone E, Shih SJ, Won MH (1992). Immunomodulatory activity of various fractions derived from Physalis angulata L. extract. Am J Chin Med, 20: 233-243.
18. Magalhães HI, Veras ML, Torres MR, Alves AP, Pessoa OD, Silveira ER, Costa-Lotufo LV, de Moraes MO, Pessoa C (2006). In vitro and in vivo antitumor activity of physalins B and D from Physalis angulata. J Pharm Pharmacol 58: 235-241.
19. Nagafuji S, Okabe H, Akahane H, Abe F (2004). Trypanocidal constituents in plants 4. Withanolides from the aerial parts of Physalis angulata. Biol Pharm Bull 27: 93-197.
20. Maistro EL, Carvalho JCT, Mantovani MS (2004). Evaluation of the genotoxic potential of the Caseaaria sylvestris extract on HCT and V79 cells by the comet assay. Toxicol in Vitro 18: 337-342.
21. Schmid W (1973). Chemical mutagen testing on in vivo somatic mammalian cells. Agents Actions 3: 77-85.
22. Singh NP, McCoy MT, Tice RR, Schneider EL (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191.
23. Soares MB, Bellintani MC, Ribeiro IM, Tomassim TC, Ribeiro dos Santos R (2003). Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L. Eur J Pharmacol 459: 107-112.
24. Surrallés J, Xamena N, Creus A, Catalán J, Norppa H, Marcos R (1995). Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocytes cultures. Mutat Res 341: 169-184.
25. Wu SJ, Ng LT, Chen CH, Lin DL, Wang SS, Lin CC (2004). Antihepatoma activity of Physalis angulata and P. Peruviana extracts and their effects on apoptosis in human Hep G2 cells. Life Sci 74: 2061-2073.