Binding of matrix metalloproteinase inhibitors to extracellular matrix: 3D-QSAR analysis

Chemical Biology and Drug Design

Volumn 72, Issue 4, 2008, Pages 237-248

  Zhang, Yufen ^a   Lukacova, Viera ^a   Bartus, Vladimir ^a   Nie, Xiaoping ^a   Sun, Guorong ^a   Manivannan, Ethirajan ^a   Ghorpade, Sandeep R ^a   Jin, Xiaomin ^a   Manyem, Shankar ^a   Sibi, Mukund P ^a   Cook, Gregory R ^a   Balaz, Stefan ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

3 dimensional quantitative structure activity relationship; Comparative Molecular Field Analysis; Disposition; Extracellular matrix; Matrix metalloproteinase inhibitors; Multiple binding modes; Pharmacokinetics; Tissue accumulation

Indexed keywords

3 PYRAZOLIDINONE DERIVATIVE; 4,5 DIHYDROOXAZOLINE DERIVATIVE; ILOMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; N CARBONYLUREA DERIVATIVE; OXAZOLINE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOACCUMULATION; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG PROTEIN BINDING; EXTRACELLULAR MATRIX; LIPOPHILICITY; PARTITION COEFFICIENT; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION;

BINDING SITES; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52649150857     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00710.x     Document Type: Article

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