RNA interference for CFTR attenuates lung fluid absorption at birth in rats

Respiratory Research

Volumn 9, Issue , 2008, Pages

  Li, Tianbo ^a   Koshy, Shyny ^a   Folkesson, Hans G ^a  

^a Northeastern Ohio Medical University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITHELIAL SODIUM CHANNEL; MESSENGER RNA; SCNN1A PROTEIN, RAT; SMALL INTERFERING RNA; TRANSMEMBRANE CONDUCTANCE REGULATOR; WATER;

ANIMAL; ARTICLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LUNG; METABOLISM; NEWBORN; PREGNANCY; RAT; RESPIRATORY TRACT MUCOSA; RNA INTERFERENCE; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL SODIUM CHANNEL; FEMALE; GENE EXPRESSION REGULATION; LUNG; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; WATER;

EID: 52649120753     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-9-55     Document Type: Article

References (49)

1. Kochanek KD, Murphy SL, Anderson RN, Scott C. Deaths: final data for 2002. Natl Vital Stat Rep 2004, 53:1-115. 15587328.
2. Bland RD, Nielson DW. Developmental changes in lung epithelial ion transport and liquid movement. Annu Rev Physiol 1992, 54:373-394. 10.1146/annurev.ph.54.030192.002105, 1314041.
3. Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelium in the adult lung. Am J Physiol 1996, 270(4 Pt 1):L487-L503. 8928808.
4. Folkesson HG, Norlin A, Baines DL. Salt and water transport across the alveolar epithelium in the developing lung: Correlations between function and recent molecular biology advances (Review). Int J Mol Med 1998, 2:515-531.
5. Matalon S, Lazrak A, Jain L, Eaton DC. Biophysical properties of sodium channels in lung alveolar epithelial cells. J Appl Physiol 2002, 93:1852-1859.
6. Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 2002, 82:569-600.
7. Olver RE, Walters DV, Wilson SM. Developmental regulation of lung liquid transport. Annu Rev Physiol 2004, 66:77-101. 10.1146/annurev.physiol.66.071702.145229, 14977397.
8. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC. Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice. Nat Genet 1996, 12:325-328. 10.1038/ng0396-325, 8589728.
9. Li T, Folkesson HG. RNA interference for α-ENaC inhibits rat lung fluid absorption in vivo. Am J Physiol Lung Cell Mol Physiol 2006, 290:L649-L660. 10.1152/ajplung.00205.2005, 16258001.
10. Ingbar DH, Burns Weeks C, Gilmore-Hebert M, Jacobsen E, Duvick S, Dowin R, Savik SK, Jamieson JD. Developmental regulation of Na, K-ATPase in rat lung. Am J Physiol 1996, 270:L619-L629. 8928822.
11. Sznajder JI, Factor P, Ingbar DH. Lung edema clearance: role of Na+-K+-ATPase. J Appl Physiol 2002, 93:1860-1866.
12. Folkesson HG, Matthay MA, Chapin CJ, Porta NFM, Kitterman JA. Pre- and postnatal lung development, maturation, and plasticity: Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines. Am J Physiol Lung Cell Mol Physiol 2002, 282:L508-L515.
13. Jiang X, Ingbar DH, O'Grady SM. Adrenergic stimulation of Na+ transport across alveolar epithelial cells involves activation of apical Cl- channels. Am J Physiol 1998, 275(6 Pt 1):C1610-C1620. 9843723.
14. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 2002, 119:199-208. 2233804, 11815669, 10.1085/jgp.119.2.199.
15. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim K-J, Crandall ED. Alveolar epithelial ion and fluid transport: Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 2002, 282:L599-L608.
16. Johnson MD, Widdicombe JH, Allen L, Barbry P, Dobbs LG. Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci USA 2002, 99:1966-1971. 122303, 11842214, 10.1073/pnas.042689399.
17. Ballard ST, Schepens SM, Falcone JC, Meininger GA, Taylor AE. Regional bioelectric properties of porcine airway epithelium. J Appl Physiol 1992, 73:2021-2027.
18. Al-Bazzaz FJ. Regulation of Na and Cl transport in sheep distal airways. Am J Physiol 1994, 267(2 Pt 1):L193-L198. 8074243.
19. Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, Jain L, Dobbs LG, Eaton DC. Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport. Proc Natl Acad Sci USA 2006, 103:4964-4969. 1458778, 16549766, 10.1073/pnas.0600855103.
20. Barker PM, Nguyen MS, Gatzy JT, Grubb B, Norman H, Hummler E, Rossier B, Boucher RC, Koller B. Role of γ ENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism. J Clin Invest 1998, 102:1634-1640. 509015, 9788978, 10.1172/JCI3971.
21. Snouwaert JN, Brigman KK, Latour AM, Malouf NN, Boucher RC, Smithies O, Koller BH. An animal model for cystic fibrosis made by gene targeting. Science 1992, 257:1083-1088. 10.1126/science.257.5073.1083, 1380723.
22. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: A laboratory manual. 2001, Plainview, N.Y., USA: Cold Spring Harbor Laboratory Press, Inc, 3.
23. Li T, Koshy S, Folkesson HG. Involvement of αENaC and Nedd4-2 in the conversion from lung fluid secretion to fluid absorption at birth in the rat as assayed by RNA interference analysis. Am J Physiol Lung Cell Mol Physiol 2007, 293:L1069-L1078. 10.1152/ajplung.00151.2007, 17693485.
24. Jassal D, Han RN, Caniggia I, Post M, Tanswell AK. Growth of distal fetal rat lung epithelial cells in a defined serum-free medium. In Vitro Cell Dev Biol Anim 1991, 27A:625-632.
25. Selinger SL, Bland RD, Demling RH, Staub NC. Distribution of volumes of 131I-albumin, 14C-sucrose and 36Cl in sheep. J Appl Physiol 1975, 39:773-779.
26. Tchepichev S, Ueda J, Canessa C, Rossier BC, O'Brodovich H. Lung epithelial Na channel subunits are differentially regulated during development and by steroids. Am J Physiol 1995, 269(3 Pt 1):C805-C812. 7573414.
27. Barker PM, Gowen CW, Lawson EE, Knowles MR. Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome. J Pediatr 1997, 130:373-377. 10.1016/S0022-3476(97)70198-7, 9063411.
28. O'Brodovich H. Deficient Na+ channel expression in newborn respiratory distress syndrome. Pediatr Pulmonol Suppl 2004, 26:141-142. 10.1002/ppul.70085, 15029631.
29. Folkesson HG, Chapin C, Beard LL, Ertsey R, Matthay MA, Kitterman JA. Congenital diaphragmatic hernia prevents clearance of distal airspace fluid in late-gestation rat fetuses. Am J Physiol Lung Cell Mol Physiol 2006, 290:L478-L484. 10.1152/ajplung.00124.2005, 16214817.
30. Garty H, Palmer LG. Epithelial sodium channels: Function, structure, and regulation. Physiol Rev 1997, 77:359-396.
31. Folkesson HG, Weström BR, Karlsson BW. Permeability of the respiratory tract to different-sized macromolecules after intratracheal instillation in young and adult rats. Acta Physiol Scand 1990, 139:347-354.
32. Sawa T, Miyazaki H, Pittet J-F, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP. Intraluminal water increases expression of plasmid DNA in rat lung. Hum Gene Ther 1996, 7:933-941. 10.1089/hum.1996.7.8-933, 8727507.
33. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. Direct gene transfer into mouse muscle in vivo. Science 1990, 247:1465-1468. 10.1126/science.1690918, 1690918.
34. Bhargava A, Dallman MF, Pearce D, Choi S. Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides. Brain Res Brain Res Protoc 2004, 13:115-125. 10.1016/j.brainresprot.2004.03.003, 15171994.
35. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. Interleukin-1β decreases expression of the epithelial sodium channel α-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem 2005, 280:18579-18589. 10.1074/jbc.M410561200, 15755725.
36. Berger M. Inflammatory mediators in cystic fibrosis lung disease. Allergy Asthma Proc 2002, 23:19-25.
37. Li S, Wu SP, Whitmore M, Loeffert EJ, Wang L, Watkins SC, Pitt BR, Huang L. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. Am J Physiol 1999, 276(5 Pt 1):L796-L804. 10330036.
38. Ma Z, Li J, He F, Wilson A, Pitt B, Li S. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Comm 2005, 330:755-759. 10.1016/j.bbrc.2005.03.041, 15809061.
39. Gondai T, Yamaguchi K, Miyano-Kurosaki N, Habu Y, Takaku H. Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon. Nucleic Acids Res 2008, 36:e18. 2241887, 18208841, 10.1093/nar/gkm1043.
40. Hummler E, Barker P, Talbot C, Wang Q, Verdumo C, Grubb B, Gatzy J, Burnier M, Horisberger J-D, Beermann F, Boucher R, Rossier BC. A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci USA 1997, 94:11710-11715. 23605, 9326675, 10.1073/pnas.94.21.11710.
41. Barker PM, Markiewicz M, Parker KA, Walters DV, Strang LB. Synergistic action of triiodothyronine and hydrocortisone on epinephrine-induced reabsorption of fetal lung liquid. Pediatr Res 1990, 27:588-591. 10.1203/00006450-199006000-00010, 2356103.
42. Finley N, Norlin A, Baines DL, Folkesson HG. Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs. J Clin Invest 1998, 101:972-981. 508648, 9486967, 10.1172/JCI1478.
43. Baines DL, Folkesson HG, Norlin A, Bingle CD, Yuan H, Olver RE. The influence of mode of delivery, hormonal status and postnatal O2 environment on epithelial sodium channel (ENaC) expression in perinatal guinea-pig lung. J Physiol 2000, 522:147-157. 10.1111/j.1469-7793.2000.t01-2-00147.xm, 10618159, 2269744.
44. Barker PM, Olver RE. Lung edema clearance: 20 years of progress. Invited review: Clearance of lung liquid during the perinatal period. J Appl Physiol 2002, 93:1542-1548.
45. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC. CFTR as a cAMP-dependent regulator of sodium channels. Science 1995, 269:847-850. 10.1126/science.7543698, 7543698.
46. Reddy MM, Light MJ, Quinton PM. Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function. Nature 1999, 402:301-304. 10.1038/46297, 10580502.
47. Kunzelmann K. The cystic fibrosis transmembrane conductance regulator and its function in epithelial transport. Rev Physiol Biochem Pharmacol 1999, 137:1-70.
48. Horisberger JD. ENaC-CFTR interactions: the role of electrical coupling of ion fluxes explored in an epithelial cell model. Pflugers Arch 2003, 445(4):522-528. 12548399.
49. Marunaka Y, Niisato N, O'Brodovich H, Eaton DC. Regulation of an amiloride-sensitive Na+-permeable channel by a β2-adrenergic agonist, cytosolic Ca2+ and Cl- in fetal rat alveolar epithelium. J Physiol 1999, 515:669-683. 10.1111/j.1469-7793.1999.669ab.x, 10066896, 2269183.