Bench-to-bedside review: The value of cardiac biomarkers in the intensive care patient

Critical Care

Volumn 12, Issue 3, 2008, Pages

  McLean, Anthony S ^a   Huang, Stephen J ^a   Salter, Mark ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CA 125 ANTIGEN; CD40 LIGAND; CHOLINE; CREATINE KINASE MB; FATTY ACID BINDING PROTEIN; HEART TYPE FATTY ACID BINDING PROTEIN; INTERLEUKIN 16; INTERLEUKIN 18; ISCHEMIA MODIFIED ALBUMIN; MYELOPEROXIDASE; TROPONIN; TROPONIN I; TROPONIN T; UNCLASSIFIED DRUG; UROCORTIN; FABP3 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; PEROXIDASE; SERUM ALBUMIN;

ACUTE HEART FAILURE; ATHEROSCLEROTIC PLAQUE; CLINICAL EVALUATION; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; DISEASE SEVERITY; ECHOCARDIOGRAPHY; HEART DISEASE; HEART FAILURE; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HUMAN; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; LUNG EMBOLISM; MYOCARDIAL DISEASE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; REVIEW; SENSITIVITY AND SPECIFICITY; SEPSIS RELATED MYOCARDIAL DYSFUNCTION; BLOOD; CARDIOVASCULAR DISEASE; HEART MUSCLE; HOSPITAL INFORMATION SYSTEM; NECROSIS; PATHOLOGY; SEPSIS;

BIOLOGICAL MARKERS; CA-125 ANTIGEN; CARDIOVASCULAR DISEASES; CD40 LIGAND; CHOLINE; CREATINE KINASE, MB FORM; FATTY ACID-BINDING PROTEINS; HUMANS; INTENSIVE CARE UNITS; INTERLEUKINS; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; NECROSIS; PEROXIDASE; POINT-OF-CARE SYSTEMS; SEPSIS; SERUM ALBUMIN; TROPONIN; UROCORTINS;

EID: 52449132113     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc6880     Document Type: Review

References (114)

1. McLean AS Huang SJ Nalos M Tang B Stewart DE The confounding effects of age, gender, serum creatinine, and electrolyte concentrations on plasma B-type natriuretic peptide concentrations in critically ill patients Crit Care Med 2003, 31:2611-2618. 14605532
2. McLean AS Tang B Nalos M Huang SJ Stewart DE Increased B-type natriuretic peptide (BNP) level is a strong predictor for cardiac dysfunction in intensive care unit patients Anaesth Intensive Care 2003, 31:21-27. 12635390
3. McLean AS Huang SJ Intensive care echocardiography 2006 Yearbook of Intensive Care and Emergency Medicine Berlin: Springer-Verlag Vincent J-L 2006, 131:141.
4. Jessup M Brozena S Heart failure N Engl J Med 2003, 348:2007-2018. 12748317
5. McLean AS Eslick GD Coats AJ The epidemiology of heart failure in Australia Int J Cardiol 2007, 118:370-374. 17046084
6. Vanderheyden M Goethals M Verstreken S De Bruyne B Muller K Van Schuerbeeck E Bartunek J Wall stress modulates brain natriuretic peptide production in pressure overload cardiomyopathy J Am Coll Cardiol 2004, 44:2349-2354. 15607397
7. Houben AJ Zander van der K de Leeuw PW Vascular and renal actions of brain natriuretic peptide in man: Physiology and pharmacology Fundam Clin Pharmacol 2005, 19:411-419. 16011727
8. Zander van der K Houben AJ Kroon AA de Leeuw PW Effects of brain natriuretic peptide on forearm vasculature: Comparison with atrial natriuretic peptide Cardiovasc Res 1999, 44:595-600. 10690292
9. Maisel AS McCord J Nowak RM Hollander JE Wu AH Duc P Omland T Storrow AB Krishnaswamy P Abraham WT Clopton P Steg G Aumont MC Westheim A Knudsen CW Perez A Kamin R Kazanegra R Herrmann HC McCullough PA Bedside B-type natriuretic peptide in the emergency diagnosis of heart failure with reduced or preserved ejection fraction. Results from the Breathing Not Properly Multinational Study J Am Coll Cardiol 2003, 41:2010-2017. 12798574
10. Davis M Espiner E Richards G Billings J Town I Neill A Drennan C Richards M Turner J Yandle T Plasma brain natriuretic peptide in assessment of acute dyspnoea Lancet 1994, 343:440-444. 7905953
11. McDonagh TA Robb SD Murdoch DR Morton JJ Ford I Morrison CE Tunstall-Pedoe H McMurray JJ Dargie HJ Biochemical detection of left-ventricular systolic dysfunction Lancet 1998, 351:9-13. 9433422
12. Januzzi JL Jr Camargo CA Anwaruddin S Baggish AL Chen AA Krauser DG Tung R Cameron R Nagurney JT Chae CU Lloyd-Jones DM Brown DF Foran-Melanson S Sluss PM Lee-Lewandrowski E Lewandrowski KB The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study Am J Cardiol 2005, 95:948-954. 15820160
13. Cowie MR Struthers AD Wood DA Coats AJ Thompson SG Poole-Wilson PA Sutton GC Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care Lancet 1997, 350:1349-1353. 9365448
14. Remme WJ Swedberg K Guidelines for the diagnosis and treatment of chronic heart failure Eur Heart J 2001, 22:1527-1560. 11492984
15. McCullough PA Nowak RM McCord J Hollander JE Herrmann HC Steg PG Duc P Westheim A Omland T Knudsen CW Storrow AB Abraham WT Lamba S Wu AH Perez A Clopton P Krishnaswamy P Kazanegra R Maisel AS B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study Circulation 2002, 106:416-422. 12135939
16. Maisel A Hollander JE Guss D McCullough P Nowak R Green G Saltzberg M Ellison SR Bhalla MA Bhalla V Clopton P Jesse R Primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT). A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath J Am Coll Cardiol 2004, 44:1328-1333. 15364340
17. McLean AS Huang SJ The applications of B-type natriuretic peptide measurement in the intensive care unit Curr Opin Crit Care 2005, 11:406-412. 16175025
18. McLean AS Poh G Huang SJ The effects of acute fluid loading on plasma B-type natriuretic peptide levels in a septic shock patient Anaesth Intensive Care 2005, 33:528-530. 16119499
19. Nellessen U Goder S Schobre R Abawi M Hecker H Tschoke S Serial analysis of troponin I levels in patients with ischemic and nonischemic dilated cardiomyopathy Clin Cardiol 2006, 29:219-224. 16739395
20. Wallace TW Abdullah SM Drazner MH Das SR Khera A McGuire DK Wians F Sabatine MS Morrow DA de Lemos JA Prevalence and determinants of troponin T elevation in the general population Circulation 2006, 113:1958-1965. 16618821
21. Liu Z Cui L Wang Y Guo Y Cardiac troponin I and ventricular arrhythmia in patients with chronic heart failure Eur J Clin Invest 2006, 36:466-472. 16796603
22. Matsumori A Kawai C Yamada T Ohkusa T Morishima S Tamaki N Watanabe Y Yonekura Y Endo K Konishi J Yoshida A Mechanism and significance of myocardial uptake of antimyosin antibody in myocarditis and cardiomyopathy: Clinical and experimental studies Clin Immunol Immunopathol 1993, 68:215-219. 8395362
23. Sato Y Kita T Takatsu Y Kimura T Biochemical markers of myocyte injury in heart failure Heart 2004, 90:1110-1113. 1768497 15367501
24. Latini R Masson S Anand IS Missov E Carlson M Vago T Angelici L Barlera S Parrinello G Maggioni AP Tognoni G Cohn JN Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure Circulation 2007, 116:1242-1249. 17698733
25. Nishio Y Sato Y Taniguchi R Shizuta S Doi T Morimoto T Kimura T Kita T Cardiac troponin T vs other biochemical markers in patients with congestive heart failure Circ J 2007, 71:631-635. 17456983
26. Mallat Z Heymes C Corbaz A Logeart D Alouani S Cohen-Solal A Seidler T Hasenfuss G Chvatchko Y Shah AM Tedgui A Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure FASEB J 2004, 18:1752-1754. 15371332
27. White M Ducharme A Ibrahim R Whittom L Lavoie J Guertin MC Racine N He Y Yao G Rouleau JL Schiffrin EL Touyz RM Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: Improvement after short-term inotropic support Clin Sci (Lond) 2006, 110:483-489. 16402915
28. Pomerantz BJ Reznikov LL Harken AH Dinarello CA Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β Proc Natl Acad Sci USA 2001, 98:2871-2876. 30232 11226333
29. Bast RC Jr Klug TL St John E Jenison E Niloff JM Lazarus H Berkowitz RS Leavitt T Griffiths CT Parker L Zurawski VR Jr Knapp RC A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer N Engl J Med 1983, 309:883-887. 6310399
30. Nagele H Bahlo M Klapdor R Schaeperkoetter D Rodiger W CA 125 and its relation to cardiac function Am Heart J 1999, 137:1044-1049. 10347329
31. D'Aloia A Faggiano P Aurigemma G Bontempi L Ruggeri G Metra M Nodari S Dei Cas L Serum levels of carbohydrate antigen 125 in patients with chronic heart failure: Relation to clinical severity, hemodynamic and Doppler echocardiographic abnormalities, and short-term prognosis J Am Coll Cardiol 2003, 41:1805-1811. 12767668
32. Kouris NT Zacharos ID Kontogianni DD Goranitou GS Sifaki MD Grassos HE Kalkandi EM Babalis DK The significance of CA125 levels in patients with chronic congestive heart failure. Correlation with clinical and echocardiographic parameters Eur J Heart Fail 2005, 7:199-203. 15701467
33. Mathew B Bhatia V Mahy IR Ahmed I Francis L Elevation of the tumor marker CA125 in right heart failure South Med J 2004, 97:1013-1014. 15558934
34. Seo T Ikeda Y Onaka H Hayashi T Kawaguchi K Kotake C Toda T Kobayashi K Usefulness of serum CA125 measurement for monitoring pericardial effusion Jpn Circ J 1993, 57:489-494. 8340995
35. Veen van der KJ Willebrands AF Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera Clin Chim Acta 1966, 13:312-316. 5943823
36. Sobel BE Shell WE Serum enzyme determinations in the diagnosis and assessment of myocardial infarction Circulation 1972, 45:471-482. 5009490
37. Collinson PO Chandler HA Stubbs PJ Moseley DS Lewis D Simmons MD Measurement of serum troponin T, creatine kinase MB isoenzyme, and total creatine kinase following arduous physical training Ann Clin Biochem 1995, 32:450-453. 8830618
38. Panteghini M Acute coronary syndrome: Biochemical strategies in the troponin era Chest 2002, 122:1428-1435. 12377875
39. Jaffe AS Ravkilde J Roberts R Naslund U Apple FS Galvani M Katus H It's time for a change to a troponin standard Circulation 2000, 102:1216-1220. 10982533
40. Alpert JS Thygesen K Antman E Bassand JP Myocardial infarction redefined - a consensus document of The Joint European Society of Cardiology/ American College of Cardiology Committee for the redefinition of myocardial infarction J Am Coll Cardiol 2000, 36:959-969. 10987628
41. De Zoysa JR Cardiac troponins and renal disease Nephrology 2004, 9:83-88. 15056267
42. Wu AH Jaffe AS The clinical need for high-sensitivity cardiac troponin assays for acute coronary syndromes and the role for serial testing Am Heart J 2008, 155:208-214. 18215588
43. Donnino MW Karriem-Norwood V Rivers EP Gupta A Nguyen HB Jacobsen G McCord J Tomlanovich MC Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysis Acad Emerg Med 2004, 11:979-981. 15347551
44. Jaffe AS Babuin L Apple FS Biomarkers in acute cardiac disease: The present and the future J Am Coll Cardiol 2006, 48:1-11. 16814641
45. Hamm CW Giannitsis E Katus HA Cardiac troponin elevations in patients without acute coronary syndrome Circulation 2002, 106:2871-2872. 12460862
46. Aviles RJ Askari AT Lindahl B Wallentin L Jia G Ohman EM Mahaffey KW Newby LK Califf RM Simoons ML Topol EJ Berger P Lauer MS Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction N Engl J Med 2002, 346:2047-2052. 12087140
47. Glatz JF Paulussen RJ Veerkamp JH Fatty acid binding proteins from heart Chem Phys Lipids 1985, 38:115-129. 4064216
48. Tanaka T Hirota Y Sohmiya K Nishimura S Kawamura K Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction Clin Biochem 1991, 24:195-201. 2040092
49. Tanaka T Sohmiya K Kitaura Y Takeshita H Morita H Ohkaru Y Asayama K Kimura H Clinical evaluation of point-of-care-testing of heart-type fatty acid-binding protein (H-FABP) for the diagnosis of acute myocardial infarction J Immunoassay Immunochem 2006, 27:225-238. 16827225
50. Ecollan P Collet JP Boon G Tanguy ML Fievet ML Haas R Bertho N Siami S Hubert JC Coriat P Montalescot G Pre-hospital detection of acute myocardial infarction with ultra-rapid human fatty acid-binding protein (H-FABP) immunoassay Int J Cardiol 2007, 119:349-354. 17097752
51. Niizeki T Takeishi Y Arimoto T Takabatake N Nozaki N Hirono O Watanabe T Nitobe J Harada M Suzuki S Koyama Y Kitahara T Sasaki T Kubota I Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients J Card Fail 2007, 13:120-127. 17395052
52. O'Donoghue M de Lemos JA Morrow DA Murphy SA Buros JL Cannon CP Sabatine MS Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes Circulation 2006, 114:550-557. 16880323
53. Libby P Inflammation in atherosclerosis Nature 2002, 420:868-874. 12490960
54. Hansson GK Inflammation, atherosclerosis, and coronary artery disease N Engl J Med 2005, 352:1685-1695. 15843671
55. Larsson PT Hallerstam S Rosfors S Wallen NH Circulating markers of inflammation are related to carotid artery atherosclerosis Int Angiol 2005, 24:43-51. 15876998
56. Pasceri V Cheng JS Willerson JT Yeh ET Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs Circulation 2001, 103:2531-2534. 11382718
57. Tanaka A Shimada K Sano T Namba M Sakamoto T Nishida Y Kawarabayashi T Fukuda D Yoshikawa J Multiple plaque rupture and C-reactive protein in acute myocardial infarction J Am Coll Cardiol 2005, 45:1594-1599. 15893172
58. Liuzzo G Biasucci LM Rebuzzi AG Gallimore JR Caligiuri G Lanza GA Quaranta G Monaco C Pepys MB Maseri A Plasma protein acute-phase response in unstable angina is not induced by ischemic injury Circulation 1996, 94:2373-2380. 8921776
59. Wong CK Szeto CC Chan MH Leung CB Li PK Lam CW Elevation of pro-inflammatory cytokines, C-reactive protein and cardiac troponin T in chronic renal failure patients on dialysis Immunol Invest 2007, 36:47-57. 17190649
60. Deodhar SD C-reactive protein: The best laboratory indicator available for monitoring disease activity Cleve Clin J Med 1989, 56:126-130. 2659202
61. Lindahl B Toss H Siegbahn A Venge P Wallentin L Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease N Engl J Med 2000, 343:1139-1147. 11036119
62. Schieffer B Schieffer E Hilfiker-Kleiner D Hilfiker A Kovanen PT Kaartinen M Nussberger J Harringer W Drexler H Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability Circulation 2000, 101:1372-1378. 10736279
63. Lindmark E Diderholm E Wallentin L Siegbahn A Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: Effects of an early invasive or noninvasive strategy JAMA 2001, 286:2107-2113. 11694151
64. Ridker PM Rifai N Stampfer MJ Hennekens CH Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men Circulation 2000, 101:1767-1772. 10769275
65. Mallat Z Corbaz A Scoazec A Besnard S Leseche G Chvatchko Y Tedgui A Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability Circulation 2001, 104:1598-1603. 11581135
66. Zirlik A Abdullah SM Gerdes N MacFarlane L Schonbeck U Khera A McGuire DK Vega GL Grundy S Libby P de Lemos JA Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: Results from the Dallas Heart Study Arterioscler Thromb Vasc Biol 2007, 27:2043-2049. 17626902
67. Blankenberg S Tiret L Bickel C Peetz D Cambien F Meyer J Rupprecht HJ Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina Circulation 2002, 106:24-30. 12093765
68. Parker MM Shelhamer JH Bacharach SL Green MV Natanson C Frederick TM Damske BA Parrillo JE Profound but reversible myocardial depression in patients with septic shock Ann Int Med 1984, 100:483-490. 6703540
69. Annane D Bellissant E Cavaillon JM Septic shock Lancet 2005, 365:63-78. 15639681
70. Cuthbertson BH Patel RR Croal BL Barclay J Hillis GS B-type natriuretic peptide and the prediction of outcome in patients admitted to intensive care Anaesthesia 2005, 60:16-21. 15601267
71. Witthaut R Busch C Fraunberger P Walli A Seidel D Pilz G Stuttmann R Speichermann N Verner L Werdan K Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: Impact of interleukin-6 and sepsis-associated left ventricular dysfunction Intensive Care Med 2003, 29:1696-1702. 12915939
72. Charpentier J Luyt CE Fulla Y Vinsonneau C Cariou A Grabar S Dhainaut JF Mira JP Chiche JD Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis Crit Care Med 2004, 32:660-665. 15090944
73. McLean AS Huang SJ Hyams S Poh G Nalos M Pandit R Balik M Tang B Seppelt I Prognostic values of B-type natriuretic peptide in severe sepsis and septic shock Crit Care Med 2007, 35:1019-1026. 17334249
74. McLean AS Huang SJ The applications of B-type natriuretic peptide measurement in the intensive care unit Curr Opin Crit Care 2005, 11:406-412. 16175025
75. ver Elst KM Spapen HD Nguyen DN Garbar C Huyghens LP Gorus FK Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock Clin Chem 2000, 46:650-657. 10794747
76. Mehta NJ Khan IA Gupta V Jani K Gowda RM Smith PR Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock Int J Cardiol 2004, 95:13-17. 15159032
77. Cunnion RE Schaer GL Parker MM Natanson C Parrillo JE The coronary circulation in human septic shock Circulation 1986, 73:637-644. 3948366
78. Ammann P Fehr T Minder EI Gunter C Bertel O Elevation of troponin I in sepsis and septic shock Intensive Care Med 2001, 27:965-969. 11497154
79. Wu AH Feng YJ Moore R Apple FS McPherson PH Buechler KF Bodor G Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization Clin Chem 1998, 44:1198-1208. 9625043
80. Amorim S Dias P Rodrigues RA Araujo V Macedo F Maciel MJ Goncalves FR Troponin I as a marker of right ventricular dysfunction and severity of pulmonary embolism Rev Port Cardiol 2006, 25:181-186. 16673648
81. Pruszczyk P N-terminal pro-brain natriuretic peptide as an indicator of right ventricular dysfunction J Card Fail 2005, 11:S65-S69. 15948104
82. Pruszczyk P Kostrubiec M Bochowicz A Styczynski G Szulc M Kurzyna M Fijalkowska A Kuch-Wocial A Chlewicka I Torbicki A N-terminal pro-brain natriuretic peptide in patients with acute pulmonary embolism Eur Respir J 2003, 22:649-653. 14582919
83. Kruger S Graf J Merx MW Koch KC Kunz D Hanrath P Janssens U Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism Am Heart J 2004, 147:60-65. 14691420
84. Renaud B Ngako A Heart-type fatty acid-binding proteins (H-FABP): A reliable tool for initial risk stratification of pulmonary embolism? Eur Heart J 2007, 28:146-147. 17208938
85. Bar-Or D Lau E Rao N Bampos N Winkler JV Curtis CG Reduction in the cobalt binding capacity of human albumin with myocardial ischemia [abstract] Ann Emerg Med 1999, 34:S56.
86. Bar-Or D Lau E Winkler JV A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia - a preliminary report J Emerg Med 2000, 19:311-315. 11074321
87. Sinha MK Roy D Gaze DC Collinson PO Kaski JC Role of 'ischemia modified albumin', a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes Emerg Med J 2004, 21:29-34. 1756335 14734370
88. Refaai MA Wright RW Parvin CA Gronowski AM Scott MG Eby CS Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery Clin Chim Acta 2006, 366:264-268. 16337614
89. Gaze DC Crompton L Collinson P Ischemia-modified albumin concentrations should be interpreted with caution in patients with low serum albumin concentrations Med Princ Pract 2006, 15:322-324. 16763404
90. Lippi G Brocco G Salvagno GL Montagnana M Dima F Guidi GC High-workload endurance training may increase serum ischemia-modified albumin concentrations Clin Chem Lab Med 2005, 43:741-744. 16207135
91. Danne O Mockel M Lueders C Mugge C Zschunke GA Lufft H Muller C Frei U Prognostic implications of elevated whole blood choline levels in acute coronary syndromes Am J Cardiol 2003, 91:1060-1067. 12714147
92. Danne O Lueders C Storm C Frei U Mockel M Whole blood choline and plasma choline in acute coronary syndromes: Prognostic and pathophysiological implications Clin Chim Acta 2007, 383:103-109. 17553478
93. Schonbeck U Mach F Libby P CD154 (CD40 ligand) Int J Biochem Cell Biol 2000 32 687 693 10856699
94. Stumpf C Lehner C Eskafi S Raaz D Yilmaz A Ropers S Schmeisser A Ludwig J Daniel WG Garlichs CD Enhanced levels of CD154 (CD40 ligand) on platelets in patients with chronic heart failure Eur J Heart Fail 2003, 5:629-637. 14607202
95. Varo N de Lemos JA Libby P Morrow DA Murphy SA Nuzzo R Gibson CM Cannon CP Braunwald E Schonbeck U Soluble CD40L: Risk prediction after acute coronary syndromes Circulation 2003, 108:1049-1052. 12912804
96. Nishikimi T Miyata A Horio T Yoshihara F Nagaya N Takishita S Yutani C Matsuo H Matsuoka H Kangawa K Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart Am J Physiol Heart Circ Physiol 2000, 279:H3031-H3039. 11087261
97. Agnello D Bertini R Sacco S Meazza C Villa P Ghezzi P Corticosteroid-independent inhibition of tumor necrosis factor production by the neuropeptide urocortin Am J Physiol 1998, 275:E757-E762. 9814993
98. Rademaker MT Charles CJ Espiner EA Fisher S Frampton CM Kirkpatrick CM Lainchbury JG Nicholls MG Richards AM Vale WW Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep J Am Coll Cardiol 2002, 40:1495-1505. 12392842
99. Ng LL Loke IW O'Brien RJ Squire IB Davies JE Plasma uro-cortin in human systolic heart failure Clin Sci (Lond) 2004, 106:383-388. 14651473
100. Tang WH Brennan ML Philip K Tong W Mann S Van Lente F Hazen SL Plasma myeloperoxidase levels in patients with chronic heart failure Am J Cardiol 2006, 98:796-799. 16950188
101. Tang WH Tong W Troughton RW Martin MG Shrestha K Borowski A Jasper S Hazen SL Klein AL Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure J Am Coll Cardiol 2007, 49:2364-2370. 17572253
102. Brennan ML Penn MS Van Lente F Nambi V Shishehbor MH Aviles RJ Goormastic M Pepoy ML McErlean ES Topol EJ Nissen SE Hazen SL Prognostic value of myeloperoxidase in patients with chest pain N Engl J Med 2003, 349:1595-1604. 14573731
103. Stolker JM Rich MW The combination of B-type natriuretic peptide and C-reactive protein provides incremental prognostic value among older patients referred for cardiac catheterization Am J Geriatr Cardiol 2007, 16:229-235. 17617749
104. Foussas SG Zairis MN Makrygiannis SS Manousakis SJ Anastassiadis FA Apostolatos CS Patsourakos NG Glyptis MP Papadopoulos JK Xenos DC Adamopoulou EN Olympios CD Argyrakis SK The significance of circulating levels of both cardiac troponin I and high-sensitivity C reactive protein for the prediction of intravenous thrombolysis outcome in patients with ST-segment elevation myocardial infarction Heart 2007, 93:952-956. 17344331
105. Peacock F Morris DL Anwaruddin S Christenson RH Collinson PO Goodacre SW Januzzi JL Jesse RL Kaski JC Kontos MC Lefevre G Mutrie D Sinha MK Uettwiller-Geiger D Pollack CV Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department Am Heart J 2006, 152:253-262. 16875905
106. Guest TM Ramanathan AV Tuteur PG Schechtman KB Ladenson JH Jaffe AS Myocardial injury in critically ill patients. A frequently unrecognized complication JAMA 1995, 273:1945-1949. 7783306
107. Noble JS Reid AM Jordan LV Glen AC Davidson JA Troponin I and myocardial injury in the ICU Br J Anaesth 1999, 82:41-46. 10325834
108. King DA Codish S Novack V Barski L Almog Y The role of cardiac troponin I as a prognosticator in critically ill medical patients: A prospective observational cohort study Crit Care 2005, 9:R390-R395. 1269455 16137352
109. Ammann P Maggiorini M Bertel O Haenseler E Joller-Jemelka HI Oechslin E Minder EI Rickli H Fehr T Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes J Am Coll Cardiol 2003, 41:2004-2009. 12798573
110. Lim W Qushmaq I Cook DJ Crowther MA Heels-Ansdell D Devereaux PJ Elevated troponin and myocardial infarction in the intensive care unit: a prospective study Crit Care 2005, 9:R636-R644. 1414005 16280062
111. Lim W Cook DJ Griffith LE Crowther MA Devereaux PJ Elevated cardiac troponin levels in critically ill patients: Prevalence, incidence, and outcomes Am J Crit Care 2006, 15:280-288. 16632770
112. Povoa P Coelho L Almeida E Fernandes A Mealha R Moreira P Sabino H C-reactive protein as a marker of infection in critically ill patients Clin Microbiol Infect 2005, 11:101-108. 15679483
113. Sierra R Rello J Bailen MA Benitez E Gordillo A Leon C Pedraza S C-reactive protein used as an early indicator of infection in patients with systemic inflammatory response syndrome Intensive Care Med 2004, 30:2038-2045. 15378239
114. Lobo SM Lobo FR Bota DP Lopes-Ferreira F Soliman HM Melot C Vincent JL C-reactive protein levels correlate with mortality and organ failure in critically ill patients Chest 2003, 123:2043-2049. 12796187