Cardiac troponins and renal disease

Nephrology

Volumn 9, Issue 2, 2004, Pages 83-88

  De Zoysa, Janak R ^a,b  

^a John Walls Renal Unit   (United Kingdom)

^b LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Chronic renal failure; Myocardial ischaemia; Troponin

Indexed keywords

CALCIUM; TROPOMYOSIN; TROPONIN; TROPONIN C; TROPONIN I; TROPONIN T;

ACTIN MYOSIN INTERACTION; ANALYTICAL EQUIPMENT; BIOCHEMISTRY; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CEREBROVASCULAR ACCIDENT; DERMATOMYOSITIS; ENDOCRINE DISEASE; HEART DEATH; HEART DISEASE; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEMATOLOGIC MALIGNANCY; HUMAN; HYPERTROPHY; KIDNEY DISEASE; KIDNEY FAILURE; POLYMYOSITIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SUBARACHNOID HEMORRHAGE;

HUMANS; KIDNEY FAILURE; MYOCARDIUM; TROPONIN;

EID: 1942435969     PISSN: 13205358     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2003.00235.x     Document Type: Review

References (89)

1. Wolfe RA, Port FK, Webb RL et al. Annual data report of the United States renal data system. VI. Causes of death. Am. J. Kidney Dis. Suppl. 1998; 32: S81-8.
2. Aronow WS, Ahn C, Mercando AD, Epstein S. Prevalence of coronary artery disease, complex ventricular arrhythmias, and silent myocardial ischemia and incidence of new coronary artery events in older persons with chronic renal insufficiency and with normal renal function. Am. J. Cardiol. 2000; 86: 1142-3.
3. Nakamura S, Uzu T, Inenaga T, Kimura G. Prediction of coronary artery disease and cardiac events using electrocardiographic changes during hemodialysis. Am. J. Kidney Dis. 2000; 36: 592-9.
4. Robbins MJ, Epstein EM, Shah S. Creatine kinase subform analysis in hemodialysis patients without acute coronary syndromes. Nephron 1997; 76: 296-9.
5. Jaffe AS, Ritter C, Meltzer V, Harter H, Roberts R. Unmasking artifactual increases in creatine kinase isoenzymes in patients with renal failure. J. Lab. Clin. Med. 1984; 104: 193-202.
6. Cummins P, Perry SV. Troponin I from human skeletal and cardiac muscles. Biochem. J. 1978; 171: 251-9.
7. Bleier J, Vorderwinkler KP, Falkensammer J et al. Different intracellular compartmentations of cardiac troponins and myosin heavy chains: A causal connection to their different early release after myocardial damage. Clin. Chem. 1998; 44: 1912-18.
8. Hunkeler NM, Kullman JAM, Murphy AM. Troponin I isoform expression in human heart. Circulation Res. 1991; 69: 1409-14.
9. Bodor GS, Porterfield D, Voss EM, Smith S, Apple FS. Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue. Clin. Chem. 1995; 41 Part 1: 1710-15.
10. Anderson PA, Malouf NN, Oakley AE, Pagani ED, Allen PD. Troponin T isoform expression in humans: A comparison among normal and failing adult, fetal heart, and adult and fetal skeletal muscle. Circulation Res. 1991; 69: 1226-33.
11. Pearlstone JR, Carpenter MR, Smillie LB. Amino acid sequence of rabbit cardiac troponin T. J. Biol. Chem. 1986; 261: 16 795-810.
12. Parmacek MS, Leiden JM. Structure and expression of the murine slow/cardiac troponin C gene. J. Biol. Chem. 1989; 264: 13217-25.
13. Cummins B, Auckland ML, Cummins P. Cardiac-specific troponin-1 radioimmunoassay in the diagnosis of acute myocardial infarction. Am. Heart J. 1987; 113: 1333-44.
14. Katus HA, Remppis A, Looser S, Hallermeier K, Scheffold T, Kuebler W. Enzyme linked immuno assay of cardiac troponin I for the detection of acute myocardial infarction in patients. J. Mol. Cell. Cardiol. 1989; 21: 1349-53.
15. Mair J, Thome-Kromer B, Wagner I et al. Concentration time courses of troponin and myosin subunits after acute myocardial infarction. Coron. Artery Dis. 1994; 5: 865-72.
16. Wu AH, Feng YJ, Contois JH, Pervaiz S. Comparison of myoglobin, creatine kinase-MB, and cardiac troponin I for diagnosis of acute myocardial infarction. Ann. Clin. Lab. Sci. 1996; 26: 291-300.
17. Burlina A, Zaninotto M, Secchiero S, Rubin D, Accorsi F. Troponin T as a marker of ischemic myocardial injury. Clin. Biochem. 1994; 27: 113-21.
18. Murthy W, Karmen A. Troponin-T as a serum marker for myocardial infarction. J. Clin. Lab. Anal. 1997; 11: 125-8.
19. Katrukha AG, Bereznikova AV, Esakova TV et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin. Chem. 1997; 43 Part 1: 1379-85.
20. Wu AH, Feng YJ, Moore R et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. Clin. Chem. 1998; 44 Part 1: 1198-208.
21. Katus HA, Remppis A, Scheffold T, Diederich KW, Kuebler W. Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am. J. Cardiol. 1991; 67: 1360-7.
22. Mair J, Artner-Dworzak E, Lechleitner P et al. Cardiac troponin T in diagnosis of acute myocardial infarction. Clin. Chem. 1991; 37: 845-52.
23. Ravkilde J, Horder M, Gerhardt W et al. Diagnostic performance and prognostic value of serum troponin T in suspected acute myocardial infarction. Scand. J. Clin. Lab. Invest. 1993; 53: 677-85.
24. Collinson PO, Moseley D, Stubbs PJ, Carter GD. Troponin T for the differential diagnosis of ischaemic myocardial damage. Ann. Clin. Biochem. 1993; 30: 11-16.
25. Hamm CW, Ravkilde J, Gerhardt W et al. The prognostic value of serum troponin T in unstable angina. N. Engl. J. Med. 1992; 327: 146-50.
26. Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction redefined: A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J. Am. Coll. Cardiol. 2000; 36: 959-69.
27. Lauer B, Niederau C, Kuhl U et al. Cardiac troponin T in patients with clinically suspected myocarditis. J. Am. Coll. Cardiol. 1997; 30: 1354-9.
28. Godon P, Guerard S, Bonnefoy E et al. Increase of tioponin I during acute pericarditis. 69 cases at an emergency service. Presse Med. 2000; 29: 127-4.
29. Ferjani M, Droc G, Dreux S et al. Circulating cardiac troponin T in myocardial contusion. Chest 1997; 111: 427-33.
30. Adams JE, Davila-Roman VG, Bessey PQ, Blake DP, Ladenson JH, Jaffe AS. Improved detection of cardiac contusion with cardiac troponin I. Am. Heart J. 1996; 131: 308-12.
31. Bertinchant JP, Polge A, Mohty D et al. Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma. J. Trauma 2000; 48: 924-31.
32. Grubb NR, Cuthbert D, Cawood P, Flapan AD, Fox KA. Effect of DC shock on serum levels of total creatine kinase, MB-creatine kinase mass and troponin T. Resuscitation 1998; 36: 193-9.
33. Neumayr G, Hagn C, Ganzer H et al. Plasma levels of troponin T after electrical cardioversion of atrial fibrillation and flutter. Am. J. Cardiol. 1997; 80: 1367-9.
34. Kobayashi S, Tanaka M, Tamura N, Hahimoto H, Hirose SI. Serum cardiac troponin T I polymyositis/dermatomyositis (letter). Lancet 1992; 340: 726.
35. Missov E, Calzolari C, Davy JM, Leclerq F, Rossi M, Pau B. Cardiac troponin I in patients with hematologic malignancies. Coron. Artery Dis. 1997; 8: 537-41.
36. Khan IA, Tun A, Wattanassauwan N et al. Elevation of serum cardiac troponin I in noncardiac and cardiac diseases other than acute coronary syndromes. Am. J. Emerg. Med. 1999; 17: 225-9.
37. Fernandes CJ, Akamine N, Knobel E. Cardiac troponin: a new serum marker of myocardial injury in sepsis. Intens. Care Med. 1999; 25: 1165-8.
38. Turner A, Tsamitros M, Bellomo R. Myocardial cell injury in septic shock. Crit. Care Med. 1999; 27: 1775-80.
39. Edouard AR, Benoist JF, Cossan C, Mimoz O, Legrand A, Samii K. Circulating troponin I in trauma patients without cardiac contusion. Intens. Care Med. 1998; 24: 569-73.
40. Guest TM, Ramanthan AV, Tuteur PG, Schechtman KB, Ladenson JH, Jaffee AS. Myocardial injury in critically ill patients. A frequently unrecognized complication. J. Am. Med. Assoc. 1995; 273: 1945-9.
41. Spies C, Haude V, Fitzner R et al. Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 1998; 113: 1055-63.
42. Kollef MH, Laderson JH, Eisenberg PR. Clinically recognized cardiac dysfunction: An independent determinant of mortality among critically ill patients. Is there a role for serial measurement of cardiac troponin I? Chest 1997; 111: 1340-7.
43. McLaurin MD, Apple FS, Voss EM, Herzog CA, Sharkey SA. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: Evidence of cardiac troponin T expression in skeletal muscle. Clin. Chem. 1997; 43: 976-82.
44. Apple FS, Sharkey SW, Hoeft P et al. Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: A 1-year outcomes analysis. Am. J. Kidney Dis. 1997; 29: 399-403.
45. Collinson PO, Hadcocks L, Foo Y et al. Cardiac noponins in patients with renal dysfunction. Ann. Clin. Biochem. 1998; 35: 380-6.
46. Ooi DS, Veinot JP, Wells GA, House AA. Increased mortality in hemodialyzed patients with elevated serum troponin T: A one-year outcome study. Clin. Biochem. 1999; 32: 647-52.
47. Willging S, Keller F, Steinbach A. Specificity of cardiac troponins I and T in renal disease. Clin. Chem. Lab. Med. 1998; 36: 87-92.
48. Hafner G, Thome-Kromer B, Schaube J et al. Cardiac troponins in serum in chronic renal failure. Clin. Chem. 1994; 40: 1790-1.
49. Adams JE, Bodor OS, Davile-Roman VG, Delmez JA, Apple FS, Ladenson JH. Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation 1993; 88: 101-6.
50. Apple FS, Christenson RH, Valdes R et al. Simultaneous rapid measurement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the Triage Cardiac Panel for detection of myocardial infarction. Clin. Chem. 1999; 45: 199-205.
51. Bhayana V, Gougoulias T, Cohoe S, Henderson AR. Discordance between results for serum troponin T and Troponin I in renal disease. Clin. Chem. 1995; 41: 312-17.
52. Wu AH, Feng YJ, Roper L, Herbert K, Schweizer R. Cardiac troponins T and I before and after renal transplantation. Clin. Chem. 1997; 43: 411-12.
53. Wayand D, Baum H, Schatzle G, Scharf J, Neumeier D. Cardiac troponin T and I in end-stage renal failure. Clin. Chem. 2000; 46: 1345-50.
54. McNeil AR, Marshall M, Ellis CJ, Hawkins RC. Why is troponin T increased in the serum of patients with end-stage renal disease? Clin. Chem. 1998; 44: 2377-8.
55. Porter GA, Norton T, Bennett WB, Troponin T. A predictor of death in chronic haemodialysis patients. Eur. Heart J. 1998; 19 (Suppl. N): N34-7.
56. Musso P, Cox I, Vidano E, Zambon D, Panteghini M. Cardiac troponin elevations in chronic renal failure: Prevalence and clinical significance. Clin. Biochem. 1999; 32: 125-30.
57. Stolear JC, Georges B, Shita A, Verbeelen D. The predictive value of cardiac troponin T measurements in subjects on regular haemodialysis. Nephrol. Dial. Transplant. 1999; 14: 1961-7.
58. Dierkes J, Domrose U, Westphal S et al. Cardiac troponin T predicts mortality in patients with end-stage renal disease. Circulation 2000; 102: 1964-9.
59. Ooi DS, Zimmerman D, Graham J, Wells GA. Cardiac troponin T predicts long-term outcomes in hemodialysis patients. Clin. Chem. 2001; 47: 412-17.
60. Roppolo LP, Fitzgerald R, Dillow J, Ziegler T, Rice M, Maisel A. A comparison of troponin T and troponin I as predictors of cardiac events in patients undergoing chronic dialysis at a veteran's hospital: A pilot study. J. Am. Coll. Cardiol. 1999; 34: 448-54.
61. Martin GS, Becker BN, Schulman G. Cardiac troponin-I accurately predicts myocardial injury in renal failure. Nephrol. Dial. Transplant 1998; 13: 1709-12.
62. McLaurin MD, Apple FS, Falahati A, Murakami MM, Miller EA, Sharkey SW. Cardiac troponin I and creatine kinase-MB mass to rule out myocardial injury in hospitalized patients with renal insufficiency. Am. J. Cardiol 1998; 82: 973-5.
63. Wu AH, Feng YJ. Biochemical differences between cTnT and cTnI and their significance for diagnosis of acute coronary syndromes. Eur. Heart J. 1998; 19 (Suppl. N): 25-9.
64. Dean KJ. Biochemistry of troponin. In: AHB Wu, ed. Cardiac Markers. Totowa: Humana Press, 1998; 193-204.
65. Fleming SM, Daly KM. Cardiac troponins in suspected acute coronary syndrome: A meta-analysis of published trials. Cardiology 2001; 95: 66-73.
66. Olatidoye AG, Wu AH, Feng YJ, Waters D. Prognostic role of troponin T versus troponin I in unstable angina pectoris for cardiac events with meta-analysis comparing published studies. Am. J. Cardiol. 1998; 81: 1405-10.
67. Labugger R, Organ L, Collier C, Atar D, Van Eyk JE. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 2000; 102: 1221-6.
68. Bodor GS, Oakeley AE, Allen PD, Crimmins DL, Ladenson JH, Anderson PA. Troponin I phosphorylation in the normal and failing adult human heart. Circulation 1997; 96: 1495-500.
69. Apple FS, Ricchiuti V, Voss EM, Anderson PA, Ney A, Odland M. Expression of cardiac troponin T isoforms in skeletal muscle of renal disease patients will not cause false-positive serum results by the second generation cardiac troponin T assay. Eur Heart J. 1998; 19 (Suppl. N): 30-3.
70. Ricchiutti V, Apple FS. RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle. Clin. Chem. 1999; 45: 2129-35.
71. Zumrutdal ZO, Bakinen O, Ucan H, Atalay HV, Bodur H. Relationship between uremic myopathy and false-positive cardiac troponin T test. Nephron 2000; 86: 522-3.
72. Mockel M, Schindler R, Knorr L et al. Prognostic value of cardiac troponin T and I elevations in renal disease patients without acute coronary syndromes: A 9-month outcome analysis. Nephrol. Dial. Transplant. 1999; 14: 1489-95.
73. Escalon JC, Wong SS. False-positive cardiac troponin T levels in chronic hemodialysis patients. Cardiology 1996; 87: 268-9.
74. Van Lente F, McErlean ES, DeLuca SA, Peacock F, Rao JS, Nissen SE. Ability of troponin to predict adverse outcomes in patients with renal insufficiency and suspected acute coronary syndromes: A case-matched study. J. Am. Coll. Cardiol. 1999; 33: 471-8.
75. Ellis K, Dreisbach AW, Lertora JJ. Plasma elimination of cardiac troponin I in end-stage renal disease. South Med. J. 2001; 94: 993-6.
76. Del Carlo CH, O'Connor CM. Cardiac troponins in congestive heart failure. Am. Heart J. 1999; 138: 646-53.
77. Sato Y, Yamada T, Taniguchi R et al. Persistently increased serum concentrations of cardiac troponin T in patients with idiopathic dilated cardiomyopathy are predictive of adverse outcomes. Circulation 2001; 103: 369-74.
78. La Vecchia L, Mezzena O, Zanolla L et al. Cardiac troponin I as diagnostic and prognostic marker in severe heart failure. J. Heart Lung Transplant. 2000; 19: 644-52.
79. Gulati J, Akella AB, Nikolic SD, Starc V, Siri F. Shifts in contractile regulatory protein subunits troponin T and troponin I in cardiac hypertrophy. Biochem. Biophys. Res. Comm. 1994; 202: 384-90.
80. Iliou MC, Fumeron C, Benoit MO et al. Factors associated with increased serum levels of cardiac troponins T and I in chronic hemodialysis patients: chronic hemodialysis and new cardiac markers evaluation (CHANCE) study. Nephrol. Dial. Transplant. 2001; 16: 1452-8.
81. Ooi DS, Isotalo PA, Veinot JP. Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology. Clin. Chem. 2000; 46: 338-44.
82. Apple FS, Murakami MM, Pearce LA, Herzog CA. Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation 2002; 106: 2941-5.
83. Lowbeer C, Stenvinkel P, Pecoits-Filho R et al. Elevated cardiac troponin T in predialysis patients is associated with inflammation and predicts mortality. J. Intern. Med. 2003; 253: 153-60.
84. Mallamaci F, Zoccali C, Parlongo S et al. Troponin is related to left ventricular mass and predicts all-cause and cardiovascular mortality in hemodialysis patients. Am. J. Kidney Dis. 2002; 40: 68-75.
85. Chapelle JP, Dubois B, Bovy C, Aldenhoff MC, Gielen J, Rorive O. Comparison of plasma cardiac troponins T and I in chronically hemodialyzed patients in relation to cardiac status and age. Clin. Chem. Lab. Med. 2002; 40: 240-5.
86. Ishii J, Nomura M, Okuma T et al. Risk stratification using serum concentrations of cardiac troponin T in patients with end-stage renal disease on chronic maintenance dialysis. Clin. Chim Acta 2001; 312: 69-79.
87. Khan IA, Wattanasuwan N, Mehta NJ et al. Prognostic value of serum cardiac troponin I in ambulatory patients with chronic renal failure undergoing long-term hemodialysis: A two-year outcome analysis. J. Am. Coll. Cardiol. 2001; 38: 991-8.
88. Lang K, Schindler S, Forberger C, Stein O, Figulla HR. Cardiac troponins have no prognostic value for acute and chronic cardiac events in asymptomatic patients with end-stage renal failure. Clin. Nephrol. 2001; 56: 44-51.
89. Aviles RJ, Askari AT, Lindahl B et al. Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N. Engl. J. Med. 2002; 346: 2047-52.