Regulatory mechanism governing the diurnal rhythm of intestinal H +/peptide cotransporter 1 (PEPT1)

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 295, Issue 2, 2008, Pages

  Saito, Hirofumi ^a   Terada, Tomohiro ^a   Shimakura, Jin ^a   Katsura, Toshiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Albumin D site binding protein; Clock gene; Restricted feeding; SLC15A1; Small intestine

Indexed keywords

FATTY ACID; PEPTIDE TRANSPORTER 1; PER1 PROTEIN; PER2 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN BMAL1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR SP1; COTRANSPORTER; DBP PROTEIN, RAT; DNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEEDING BEHAVIOR; GEL MOBILITY SHIFT ASSAY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SMALL INTESTINE; ANIMAL; BLOOD; CALORIC RESTRICTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANIMALS; BASE SEQUENCE; CALORIC RESTRICTION; CIRCADIAN RHYTHM; DNA-BINDING PROTEINS; FATTY ACIDS, NONESTERIFIED; MALE; MICE; MOLECULAR SEQUENCE DATA; PPAR ALPHA; RATS; SYMPORTERS; TRANSCRIPTION FACTORS;

EID: 52449116546     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90317.2008     Document Type: Article

References (37)

1. Adibi SA. Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Am J Physiol Gastrointest Liver Physiol 285: G779-G788, 2003.
2. Ashida K, Katsura T, Motohashi H, Saito H, Inui K. Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 282: G617-G623, 2002.
3. Balsalobre A, Brown SA, Marcacci L, Tronche F, Kellendonk C, Reichardt HM, Schutz G, Schibler U. Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289: 2344-2347, 2000.
4. Damiola F, Le Minh N, Preitner N, Kornmann B, Fleury-Olela F, Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 14: 2950-2961, 2000.
5. Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol 66: 361-384, 2004.
6. Duffield GE, Best JD, Meurers BH, Bittner A, Loros JJ, Dunlap JC. Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr Biol 12: 551-557, 2002.
7. Fisher RB, Gardner ML. A diurnal rhythm in the absorption of glucose and water by isolated rat small intestine. J Physiol 254: 821-825, 1976.
8. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280: 1564-1569, 1998.
9. Gibbons GF, Patel D, Wiggins D, Knight BL. The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor-alpha (PPAR-α). Adv Enzyme Regul 42: 227-247, 2002.
10. Ihara T, Tsujikawa T, Fujiyama Y, Bamba T. Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditions. Digestion 61: 59-67, 2000.
11. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98: 193-205, 1999.
12. Lavery DJ, Lopez-Molina L, Margueron R, Fleury-Olela F, Conquet F, Schibler U, Bonfils C. Circadian expression of the steroid 15 α-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Mol Cell Biol 19: 6488-6499, 1999.
13. Lee YH, Alberta JA, Gonzalez FJ, Waxman DJ. Multiple, functional DBP sites on the promoter of the cholesterol 7α-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. J Biol Chem 269: 14681-14689, 1994.
14. Matthews DM. Intestinal absorption of peptides. Physiol Rev 55: 537-608, 1975.
15. Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, Atsumi G, Ohkura N, Azama T, Mesaki M, Yukimasa S, Kobayashi H, Iitaka C, Umehara T, Horikoshi M, Kudo T, Shimizu Y, Yano M, Monden M, Machida K, Matsuda J, Horie S, Todo T, Ishida N. Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J Biol Chem 278: 41519-41527, 2003.
16. +-peptide cotransporter in rat small intestine. Am J Physiol Gastrointest Liver Physiol 283: G57-G64, 2002.
17. Pan X, Terada T, Okuda M, Inui K. Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten. J Pharmacol Exp Ther 307: 626-632, 2003.
18. Pan X, Terada T, Okuda M, Inui K. The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats. J Nutr 134: 2211-2215, 2004.
19. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109: 307-320, 2002.
20. Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol 63: 647-676, 2001.
21. + exchanger NHE3 in the kidney. Kidney Int 67: 1410-1419, 2005.
22. Shimakura J, Terada T, Katsura T, Inui K. Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1. Am J Physiol Gastrointest Liver Physiol 289: G471-G477, 2005.
23. Shimakura J, Terada T, Saito H, Katsura T, Inui K. Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor α. Am J Physiol Gastrointest Liver Physiol 291: G851-G856, 2006.
24. Shimakura J, Terada T, Shimada Y, Katsura T, Inui K. The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1. Biochem Pharmacol 71: 1581-1588, 2006.
25. Sladek M, Rybova M, Jindrakova Z, Zemanova Z, Polidarova L, Mrnka L, O'Neill J, Pacha J, Sumova A. Insight into the circadian clock within rat colonic epithelial cells. Gastroenterology 133: 1240-1249, 2007.
26. Stevenson NR, Fierstein JS. Circadian rhythms of intestinal sucrase and glucose transport: cued by time of feeding. Am J Physiol 230: 731-735, 1976.
27. Stokkan KA, Yamazaki S, Tei H, Sakaki Y, Menaker M. Entrainment of the circadian clock in the liver by feeding. Science 291: 490-493, 2001.
28. Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ. Extensive and divergent circadian gene expression in liver and heart. Nature 417: 78-83, 2002.
29. Sunaga K, Fujimura A, Shiga T, Ebihara A. Chronopharmacology of enalapril in hypertensive patients. Eur J Clin Pharmacol 48: 441-445, 1995.
30. Takiguchi T, Tomita M, Matsunaga N, Nakagawa H, Koyanagi S, Ohdo S. Molecular basis for rhythmic expression of CYP3A4 in serumshocked HepG2 cells. Pharmacogenet Genomics 17: 1047-1056, 2007.
31. Terada T, Inui K. Peptide transporters: structure, function, regulation and application for drug delivery. Curr Drug Metab 5: 85-94, 2004.
32. Thamotharan M, Bawani SZ, Zhou X, Adibi SA. Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast. Metabolism 48: 681-684, 1999.
33. Tsuda M, Terada T, Irie M, Katsura T, Niida A, Tomita K, Fujii N, Inui K. Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther 318: 455-460, 2006.
34. Yamaguchi S, Mitsui S, Yan L, Yagita K, Miyake S, Okamura H. Role of DBP in the circadian oscillatory mechanism. Mol Cell Biol 20: 4773-4781, 2000.
35. Yamamoto T, Nakahata Y, Soma H, Akashi M, Mamine T, Takumi T. Transcriptional oscillation of canonical clock genes in mouse peripheral tissues. BMC Mol Biol 5: 18, 2004.
36. Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, Ueda M, Block GD, Sakaki Y, Menaker M, Tei H. Resetting central and peripheral circadian oscillators in transgenic rats. Science 288: 682-685, 2000.
37. Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ, Menaker M, Takahashi JS. PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA 101: 5339-5346, 2004.