Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor α

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 5, 2006, Pages

  Shimakura, Jin ^a   Terada, Tomohiro ^a   Saito, Hirofumi ^a   Katsura, Toshiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Caco 2; Glycylsarcosine; SLC15A1; Small intestine; Starvation

Indexed keywords

FATTY ACID; GLYCYLSARCOSINE; GW 501516; PEPTIDE TRANSPORTER 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIOGLITAZONE; PIRINIXIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; RECEPTOR UPREGULATION; SMALL INTESTINE;

ACYL-COA OXIDASE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CACO-2 CELLS; CELLS, CULTURED; FASTING; FATTY ACIDS, NONESTERIFIED; HUMANS; LIGANDS; MALE; MICE; MICE, KNOCKOUT; PPAR ALPHA; PYRIMIDINES; RATS; RATS, WISTAR; RNA, MESSENGER; SYMPORTERS;

EID: 33751071092     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00171.2006     Document Type: Article

References (43)

1. Adibi SA. Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Am J Physiol Gastrointest Liver Physiol 285: G779-G788, 2003.
2. Ashida K, Katsura T, Motohashi H, Saito H, and Inui K. Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 282: G617-G623, 2002.
3. 2-Adrenergic receptors stimulate oligopeptide transport in a human intestinal cell line. J Pharmacol Exp Ther 294: 466-472, 2000.
4. Dallman MF, Akana SF, Bhatnagar S, Bell ME, Choi S, Chu A, Horsley C, Levin N, Meijer O, Soriano LR, Strack AM, and Viau V. Starvation: early signals, sensors, and sequelae. Endocrinology 140: 4015-4023, 1999.
5. Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol 66: 361-384, 2004.
6. Daniel H and Herget M. Cellular and molecular mechanisms of renal peptide transport. Am J Physiol Renal Physiol 273: F1-F8, 1997.
7. Desvergne B and Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20: 649-688, 1999.
8. Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, and Desvergne B. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 142: 4195-4202, 2001.
9. +/peptide transporter PEPT1 in the human intestinal cell line Caco-2. Biochem Biophys Res Commun 261: 242-246, 1999.
10. Gangopadhyay A, Thamotharan M, and Adibi SA. Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Am J Physiol Gastrointest Liver Physiol 283: G133-G138, 2002.
11. Hediger MA and Rhoads DB. Molecular physiology of sodium-glucose cotransporters. Physiol Rev 74: 993-1026, 1994.
12. Hihi AK, Michalik L, and Wahli W. PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 59: 790-798, 2002.
13. +-dependent glucose transporter (NaGLT1) in rat kidney. J Biol Chem 278: 14669-14676, 2003.
14. Ihara T, Tsujikawa T, Fujiyama Y, and Bamba T. Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditions. Digestion 61: 59-67, 2000.
15. Inui K and Terada T. Dipeptide transporters. In: Membrane Transporters as Drug Targets, edited by Amidon GL and Sadée W. New York: Plenum, 1999, p. 269-288.
16. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, and Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103: 1489-1498, 1999.
17. Kersten S, Mandard S, Escher P, Gonzalez FJ, Tafuri S, Desvergne B, and Wahli W. The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. FASEB J 15: 1971-1978, 2001.
18. Knight BL, Patel DD, Humphreys SM, Wiggins D, and Gibbons GF. Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. J Lipid Res 44: 2049-2058, 2003.
19. Landrier JF, Thomas C, Grober J, Zaghini I, Petit V, Poirier H, Niot I, and Besnard P. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. Biochim Biophys Acta 1735: 41-49, 2005.
20. Leibach FH and Ganapathy V. Peptide transporters in the intestine and the kidney. Annu Rev Nutr 16: 99-119, 1996.
21. Leone TC, Weinheimer CJ, and Kelly DP. A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 96: 7473-7478, 1999.
22. Matthews DM. Intestinal absorption of peptides. Physiol Rev 55: 537-608, 1975.
23. McManus JP and Isselbacher KJ. Effect of fasting versus feeding on the rat small intestine. Morphological, biochemical, and functional differences. Gastroenterology 59: 214-221, 1970.
24. Meredith D and Boyd CA. Structure and function of eukaryotic peptide transporters. Cell Mol Life Sci 57: 754-778, 2000.
25. Motojima K. 17Beta-hydroxysteroid dehydrogenase type 11 is a major peroxisome proliferator-activated receptor alpha-regulated gene in mouse intestine. Eur J Biochem 271: 4141-4146, 2004.
26. Naruhashi K, Sai Y, Tamai I, Suzuki N, and Tsuji A. Pept1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine. Pharm Res 19: 1417-1423, 2002.
27. Nielsen CU, Amstrup J, Steffansen B, Frokjaer S, and Brodin B. Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line. Am J Physiol Gastrointest Liver Physiol 281: G191-G199, 2001.
28. Ogihara H, Suzuki T, Nagamachi Y, Inui K, and Takata K. Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids. Histochem J 31: 169-174, 1999.
29. +-peptide cotransporter in the rat small intestine. Am J Physiol Gastrointest Liver Physiol 283: G57-G64, 2002.
30. Pan X, Terada T, Okuda M, and Inui K. Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten. J Pharmacol Exp Ther 307: 626-632, 2003.
31. Pan X, Terada T, Okuda M, and Inui K. The diurnal rhythm of the intestinal transporters SGLT1 and PEPT1 is regulated by the feeding conditions in rats. J Nutr 134: 2211-2215, 2004.
32. Seree E, Villard PH, Pascussi JM, Pineau T, Maurel P, Nguyen QB, Fallone F, Martin PM, Champion S, Lacarelle B, Savouret JF, and Barra Y. Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology 127: 1436-1445, 2004.
33. Shimakura J, Terada T, Katsura T, and Inui K. Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1. Am J Physiol Gastrointest Liver Physiol 289: G471-G477, 2005.
34. Shimakura J, Terada T, Shimada Y, Katsura T, and Inui K. The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1. Biochem Pharmacol 71: 1581-1588, 2006.
35. +/peptide transporter PepT1. Gastroenterology 116: 354-362, 1999.
36. Stannard SR, Thompson MW, Fairbairn K, Huard B, Sachinwalla T, and Thompson CH. Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men. Am J Physiol Endocrinol Metab 283: E1185-E1191, 2002.
37. Suruga K, Mochizuki K, Suzuki R, Goda T, and Takase S. Regulation of cellular retinol-binding protein type II gene expression by arachidonic acid analogue and 9-cis retinoic acid in Caco-2 cells. Eur J Biochem 262: 70-78, 1999.
38. Terada T, Saito H, Mukai M, and Inui K. Recognition of β-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol Renal Physiol 273: F706-F711, 1997.
39. Terada T and Inui K. Peptide transporters: structure, function, regulation and application for drug delivery. Curr Drug Metab 5: 85-94, 2004.
40. +/peptide cotransporter 2 causes a complete loss of transport function. Biochem Biophys Res Commun 316: 416-420, 2004.
41. Terada T, Shimada Y, Pan X, Kishimoto K, Sakurai T, Doi R, Onodera H, Katsura T, Imamura M, and Inui K. Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract. Biochem Pharmacol 70: 1756-1763, 2005.
42. Thamotharan M, Bawani SZ, Zhou X, and Adibi SA. Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast. Metabolism 48: 681-684, 1999.
43. Van den Berghe G. The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism. J Inherit Metab Dis 14: 407-420, 1991.