Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 289, Issue 3 52-3, 2005, Pages

  Shimakura, Jin ^a   Terada, Tomohiro ^a   Katsura, Toshiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Caco 2; SLC15A1; Small intestine

Indexed keywords

MITHRAMYCIN; MITHRAMYCIN A; PEPTIDE TRANSPORTER 1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BRUSH BORDER; CELL STRAIN CACO 2; DOSE RESPONSE; EPITHELIUM CELL; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION;

CACO-2 CELLS; GENE EXPRESSION REGULATION; HUMANS; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR; SYMPORTERS; TRANSCRIPTION, GENETIC;

EID: 24044461724     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00025.2005     Document Type: Article

References (29)

1. Adibi SA. Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Am J Physiol Gastrointest Liver Physiol 285: G779-G788, 2003.
2. Ashida K, Katsura T, Motohashi H, Saito H, and Inui K. Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 282: G617-0623, 2002.
3. 2-Adrenergic receptors stimulate oligopeptide transport in a human intestinal cell line. J Pharmacol Exp Ther 294: 466-472, 2000.
4. Black AR, Black JD, and Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 188: 143-160, 2001.
5. Blake MC, Jambou RC, Swick AG, Kahn JW, and Azizkhan JC. Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter. Mol Cell Biol 10: 6632-6641, 1990.
6. Blume SW, Snyder RC, Ray R, Thomas S, Koller CA, and Miller DM. Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J Clin Invest 88: 1613-1621, 1991.
7. Buyse M, Charrier L, Sitaraman S, Gewirtz A, and Merlin D. Interferon-γ increases hPepT1-mediated uptake of di-tripeptides including the bacterial tripeptide fMLP in polarized intestinal epithelia. Am J Pathol 163: 1969-1977, 2003.
8. Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol 66: 361-384, 2004.
9. Fei YJ, Sugawara M, Liu JC, Li HW, Ganapathy V, Ganapathy ME, and Leibach FH. cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim Biophys Acta 1492: 145-154, 2002.
10. +/peptide transporter PEPT1 in the human intestinal cell line Caco-2. Biochem Biophys Res Commun 261: 242-246, 1999.
11. Gangopadhyay A, Thamotharan M, and Adibi SA. Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Am J Physiol Gastrointest Liver Physiol 283: G133-G138, 2002.
12. Li L, He S, Sun JM, and Davie JR. Gene regulation by Sp1 and Sp3. Biochem Cell Biol 82: 460-471, 2004.
13. +-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1. Am J Physiol Gastrointest Liver Physiol 278: G591-G603, 2000.
14. Mastrangelo IA, Courey AJ, Wall JS, Jackson SP, and Hough PVC. DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc Natl Acad Sci USA 88: 5670-5674, 1991.
15. Mitchelmore C, Troelsen JT, Spodsberg N, Sjostrom H, and Noren O. Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene. Biochem J 346: 529-535, 2000.
16. Nabokina SM and Said HM. Characterization of the 5′-regulatory region of the human thiamin transporter SLC19A3: in vitro and in vivo studies. Am J Physiol Gastrointest Liver Physiol 287: G822-G829, 2004.
17. Naruhashi K, Sai Y, Tamai I, Suzuki N, and Tsuji A. Pept1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine. Pharm Res 19: 1417-1423, 2002.
18. Nielsen CU, Amstrup J, Steffansen B, Frokjaer S, and Brodin B. Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line. Am J Physiol Gastrointest Liver Physiol 281: G191-G199, 2001.
19. +-peptide cotransporter in the rat small intestine. Am J Physiol Gastrointest Liver Physiol 283: G57-G64, 2002.
20. Pugh BF and Tjian R. Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev 5: 1935-1945, 1991.
21. Ray R, Snyder RC, Thomas S, Koller CA, and Miller DM. Mithramycin blocks protein binding and function of the SV40 early promoter. J Clin Invest 83: 2003-2007, 1989.
22. Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, and Reinecker HC. Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1 alpha. J Biol Chem 277: 21361-21370, 2002.
23. Shields JM, Christy RJ, and Yang VW. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem 271: 20009-20017, 1996.
24. +/peptide transporter PepT1. Gastroenterology 116: 354-362, 1999.
25. Silberg DG, Swain GP, Suh ER, and Traber PG. Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 119: 961-971, 2000.
26. Suh E, Chen L, Taylor J, and Traber PG. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 14: 7340-7351, 1994.
27. Suh E and Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 16: 619-625, 1996.
28. Terada T and Inui K. Peptide transporters: structure, function, regulation and application for drug delivery. Curr Drug Metabol 5: 85-94, 2004.
29. Urtti A, Johns SJ, and Sadee W. Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH sensing regulatory splice variant. AAPS Pharm Sci 3: E6, 2001.