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Volumn 49, Issue 5, 2008, Pages 541-548

Enhancement of radiosensitivity by roscovitine pretreatment in human non-small cell lung cancer A549 cells

Author keywords

A549 cells; Apoptosis; Caspase 3; DNA repair; Ionizing radiation; Roscovitine

Indexed keywords

BIOLOGICAL ORGANS; CELL CULTURE; DISEASES; DNA; FLOW CYTOMETRY; GAMMA RAYS; PROTEINS; RADIOTHERAPY; REPAIR;

EID: 52249092188     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1269/jrr.08024     Document Type: Article
Times cited : (26)

References (25)
  • 1
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    • Meijer, L., Borgne, A., Mulner, O., Chong, J. P.. Blow, J. J. and Inagaki, N. et al. (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biocheml. 243: 527-536.
    • (1997) Eur J Biocheml , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3    Chong, J.P.4    Blow, J.J.5    Inagaki, N.6
  • 2
    • 27144512221 scopus 로고    scopus 로고
    • Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo
    • Tirado, O. M., Mateo-Lozano, S. and Notario, V. (2005) Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo. Cancer Res. 65: 9320-9327.
    • (2005) Cancer Res , vol.65 , pp. 9320-9327
    • Tirado, O.M.1    Mateo-Lozano, S.2    Notario, V.3
  • 3
    • 24744434754 scopus 로고    scopus 로고
    • Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells
    • Mohapatra, S., Chu, B., Zhao, X. H. and Pledger, W. J. (2005) Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells. Cancer Res. 65: 7717-7723.
    • (2005) Cancer Res , vol.65 , pp. 7717-7723
    • Mohapatra, S.1    Chu, B.2    Zhao, X.H.3    Pledger, W.J.4
  • 4
    • 0041622837 scopus 로고    scopus 로고
    • Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells
    • Wojciechowski, J., Horky, M., Gueorguieva, M. and Wesierska-Gadek, J. (2002) Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells. Int J Cancer. 106: 486-495.
    • (2002) Int J Cancer , vol.106 , pp. 486-495
    • Wojciechowski, J.1    Horky, M.2    Gueorguieva, M.3    Wesierska-Gadek, J.4
  • 5
    • 0347626096 scopus 로고    scopus 로고
    • Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2
    • Mohapatra, S., Chu, B., Wei, S., Djeu, J., Epling-Bumette, P. K. and Loughran, T. et al. (2003) Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 63: 8523-8530.
    • (2003) Cancer Res , vol.63 , pp. 8523-8530
    • Mohapatra, S.1    Chu, B.2    Wei, S.3    Djeu, J.4    Epling-Bumette, P.K.5    Loughran, T.6
  • 6
    • 28144434721 scopus 로고    scopus 로고
    • Roscovitine Modulates DNA repair and senescence: Implications for combination chemotherapy
    • Crescenzi, E., Palumbo, G. and Brady, H. J. (2005) Roscovitine Modulates DNA repair and senescence: implications for combination chemotherapy. Clin Cancer Res. 11: 8158-8171.
    • (2005) Clin Cancer Res , vol.11 , pp. 8158-8171
    • Crescenzi, E.1    Palumbo, G.2    Brady, H.J.3
  • 7
    • 0038519961 scopus 로고    scopus 로고
    • Enhancement of radiation response by roscovitine in human breast carcinoma in Vitro and in Vivo
    • Maggiorella, L., Deutsch, E., Frascogna, V., Chavaudra, N., Jeanson, L. and Milliat, F. et al. (2003) Enhancement of radiation response by roscovitine in human breast carcinoma in Vitro and in Vivo. Cancer Res. 63: 2513-2517.
    • (2003) Cancer Res , vol.63 , pp. 2513-2517
    • Maggiorella, L.1    Deutsch, E.2    Frascogna, V.3    Chavaudra, N.4    Jeanson, L.5    Milliat, F.6
  • 8
    • 0033561531 scopus 로고    scopus 로고
    • Roscovitine induces cell death and morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells
    • Mgbonyebi, O. P., Russo, J. and Russo, I. H. (1999) Roscovitine induces cell death and morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells. Cancer Res. 59: 1903-1910.
    • (1999) Cancer Res , vol.59 , pp. 1903-1910
    • Mgbonyebi, O.P.1    Russo, J.2    Russo, I.H.3
  • 9
    • 11144316653 scopus 로고    scopus 로고
    • Cyclin dependent kinase inhibitor roscovitine induces apoptosis in chronic lym-phocytic leukemia cells
    • Hahntow, I. N., Schneller, F., Oelsner, M., Weick, K., Ringshausen, I. and Fend, F. et al. (2004) Cyclin dependent kinase inhibitor roscovitine induces apoptosis in chronic lym-phocytic leukemia cells. Leukemia. 18: 747-755.
    • (2004) Leukemia , vol.18 , pp. 747-755
    • Hahntow, I.N.1    Schneller, F.2    Oelsner, M.3    Weick, K.4    Ringshausen, I.5    Fend, F.6
  • 10
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V
    • Vermes, I., Haanen, C., Steffens-Nakken, H. and Reutelingsperger, C. (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J Immunol Methods. 184: 39-51.
    • (1995) J Immunol Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 11
    • 0028102478 scopus 로고
    • Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. and Earnshaw, W. C. (1994) Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371: 346-347.
    • (1994) Nature , vol.371 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 12
    • 0038745560 scopus 로고    scopus 로고
    • Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells
    • Raju, U., Nakata, E., Mason, K. A., Ang, K. K. and Milas, L. (2003) Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Cancer Res. 63: 3263-3267.
    • (2003) Cancer Res , vol.63 , pp. 3263-3267
    • Raju, U.1    Nakata, E.2    Mason, K.A.3    Ang, K.K.4    Milas, L.5
  • 13
    • 0028925622 scopus 로고
    • Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells
    • Palayoor, S. T., Macklis, R. M., Bump, E. A. and Coleman, C. N. (1995) Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells. Radiat Res. 141: 235-243.
    • (1995) Radiat Res , vol.141 , pp. 235-243
    • Palayoor, S.T.1    Macklis, R.M.2    Bump, E.A.3    Coleman, C.N.4
  • 14
    • 0032587587 scopus 로고    scopus 로고
    • G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation
    • Ning, S. and Knox, S. J. (1999) G2/M-phase arrest and death by apoptosis of HL60 cells irradiated with exponentially decreasing low-dose-rate gamma radiation. Radiat Res. 151: 659-669.
    • (1999) Radiat Res , vol.151 , pp. 659-669
    • Ning, S.1    Knox, S.J.2
  • 15
    • 3042661957 scopus 로고    scopus 로고
    • Role of cell cycle in mediating sensitivity to radiotherapy
    • Pawlik, T. M. and Keyomarsi, K. (2004) Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys. 59: 928-942.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 928-942
    • Pawlik, T.M.1    Keyomarsi, K.2
  • 16
    • 33947224658 scopus 로고    scopus 로고
    • Breaking chemoresistance and radioresistance with [213Bi] anti-CD45 antibodies in leukemia cells
    • Friesen, C., Glatting, G., Koop, B., Schwarz, K., Morgenstern, A. and Apostolidis, C. et al. (2007) Breaking chemoresistance and radioresistance with [213Bi] anti-CD45 antibodies in leukemia cells. Cancer Res. 67: 1950-1958.
    • (2007) Cancer Res , vol.67 , pp. 1950-1958
    • Friesen, C.1    Glatting, G.2    Koop, B.3    Schwarz, K.4    Morgenstern, A.5    Apostolidis, C.6
  • 17
    • 33749599776 scopus 로고    scopus 로고
    • Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase
    • Petermann, E. and Caldecott, K. W. (2006) Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle. 5: 2203-2209.
    • (2006) Cell Cycle , vol.5 , pp. 2203-2209
    • Petermann, E.1    Caldecott, K.W.2
  • 18
    • 33645283870 scopus 로고    scopus 로고
    • BID as a double agent in cell life and death
    • Gross, A. (2006) BID as a double agent in cell life and death. Cell Cycle. 5: 582-584.
    • (2006) Cell Cycle , vol.5 , pp. 582-584
    • Gross, A.1
  • 20
    • 33846663007 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions
    • He, F., Li, L., Kim, D., Wen, B., Deng, X. and Gutin, P. H. et al. (2007) Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions. Cancer Res. 67: 634-642.
    • (2007) Cancer Res , vol.67 , pp. 634-642
    • He, F.1    Li, L.2    Kim, D.3    Wen, B.4    Deng, X.5    Gutin, P.H.6
  • 21
    • 0242525123 scopus 로고    scopus 로고
    • Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma
    • Shintani, S., Mihara, M., Li, C., Nakahara, Y., Hino, S. and Nakashiro, K. et al. (2003) Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma. Cancer Sci. 94: 894-900.
    • (2003) Cancer Sci , vol.94 , pp. 894-900
    • Shintani, S.1    Mihara, M.2    Li, C.3    Nakahara, Y.4    Hino, S.5    Nakashiro, K.6
  • 22
    • 2942612900 scopus 로고    scopus 로고
    • DNA-PK: The major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway
    • Hashimoto, M., Rao, S., Tokono, O., Yamamoto, K. I., Takata, M. and Takeda, S. et al. (2003) DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway. J Radiat Res. 44: 151-159.
    • (2003) J Radiat Res , vol.44 , pp. 151-159
    • Hashimoto, M.1    Rao, S.2    Tokono, O.3    Yamamoto, K.I.4    Takata, M.5    Takeda, S.6
  • 23
    • 0037195933 scopus 로고    scopus 로고
    • Expression of Ku70 and Ku80 mediated by NF-κB and cyclooxygenase-2 is related to proliferation of human gastric cancer cells
    • Lim, J. W., Kim, H. and Kim, K. H. (2002) Expression of Ku70 and Ku80 mediated by NF-κB and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. J Biol Chem. 277: 46093-46100.
    • (2002) J Biol Chem , vol.277 , pp. 46093-46100
    • Lim, J.W.1    Kim, H.2    Kim, K.H.3
  • 24
    • 38149082690 scopus 로고    scopus 로고
    • R-roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis: Implications in cancer therapy
    • Dey, A., Wong, E. T., Cheok, C. F., Tergaonkar, V. and Lane, D. P. (2008) R-roscovitine simultaneously targets both the p53 and NF-κB pathways and causes potentiation of apoptosis: implications in cancer therapy. Cell Death Differ. 15: 263-273.
    • (2008) Cell Death Differ , vol.15 , pp. 263-273
    • Dey, A.1    Wong, E.T.2    Cheok, C.F.3    Tergaonkar, V.4    Lane, D.P.5
  • 25
    • 0034777846 scopus 로고    scopus 로고
    • The impact of p53 status on cellular sensitivity to antifolate drugs
    • Lu, X. H., Ellington, J., Curtin, N. L, Lunec, J. and Newell, D. R. (2001) The impact of p53 status on cellular sensitivity to antifolate drugs. Clin Cancer Res. 7: 2114-2123.
    • (2001) Clin Cancer Res , vol.7 , pp. 2114-2123
    • Lu, X.H.1    Ellington, J.2    Curtin, N.L.3    Lunec, J.4    Newell, D.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.