Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy

Toxicology and Applied Pharmacology

Volumn 232, Issue 2, 2008, Pages 327-336

  Perez, Maria J ^a   Castaño, Beatriz ^b   Jimenez, Silvia ^b   Serrano, Maria A ^b   Gonzalez Buitrago, Jose M ^a   Marin, Jose J G ^b  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Bile acid; Biliverdin; Mitochondria; Oxidative stress; Pregnancy; Reactive oxygen species; Vitamin C

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; BILE ACID; BILIRUBIN; BILIVERDIN; BILIVERDIN REDUCTASE; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; DEOXYCHOLIC ACID; ENZYME; FARNESOID X RECEPTOR; PREGNANE X RECEPTOR; PROTEIN; PROTEIN SVCT1; PROTEIN SVCT2; REACTIVE OXYGEN METABOLITE; SMALL HETERODIMER PARTNER; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CELL VIABILITY; CHOLESTASIS; CONTROLLED STUDY; FEMALE; FETUS; HUMAN; HUMAN CELL; LIVER; LIVER CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; OXIDATIVE STRESS; PLACENTA; PREGNANCY; PREGNANCY OUTCOME; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL LINE, TUMOR; CHOLESTASIS; FEMALE; HUMANS; MALE; MATERNAL-FETAL EXCHANGE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; OXIDATIVE STRESS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PREGNANCY; PREGNANCY COMPLICATIONS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; URSODEOXYCHOLIC ACID;

RATTUS;

EID: 52049125004     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.07.013     Document Type: Article

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