Cyclosporine Preserves Mitochondrial Morphology After Myocardial Ischemia/Reperfusion Independent of Calcineurin Inhibition

Annals of Thoracic Surgery

Volumn 86, Issue 4, 2008, Pages 1286-1292

  Leshnower, Bradley G ^a   Kanemoto, Shinya ^a   Matsubara, Muneaki ^a   Sakamoto, Hiroaki ^a   Hinmon, Robin ^a   Gorman III, Joseph H ^a   Gorman, Robert C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN; DRUG VEHICLE; EVANS BLUE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; TACROLIMUS; TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; GENE DISRUPTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; HEART PROTECTION; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RABBIT; TRANSMISSION ELECTRON MICROSCOPY;

ANALYSIS OF VARIANCE; ANIMALS; CALCINEURIN; CYCLOSPORINE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; PROBABILITY; RABBITS; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; TACROLIMUS;

EID: 52049119777     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2008.06.033     Document Type: Article

References (25)

1. Halestrap A.P. Calcium, mitochondria and reperfusion injury: a pore way to die. Biochem Soc Trans 34 (2006) 232-237
2. Nazareth W., Yafei N., and Crompton M. Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A. J Mol Cell Cardiol 23 (1991) 1351-1354
3. Weinbrenner C., Liu G.S., Downey J.M., and Cohen M.V. Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia. Cardiovasc Res 38 (1998) 678-684
4. Griffiths E.J., and Halestrap A.P. Protection by cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts. J Mol Cell Cardiol 25 (1993) 1461-1469
5. Hausenloy D.J., Maddock H.L., Baxter G.F., and Yellon D.M. Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?. Cardiovasc Res 55 (2002) 534-543
6. Argaud L., Gateau-Roesch O., Muntean D., et al. Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J Mol Cell Cardiol 38 (2005) 367-374
7. Griffiths E.J., and Halestrap A.P. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 307 (1995) 93-98
8. Halestrap A.P., Connern C.P., Griffiths E.J., and Kerr P.M. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol Cell Biochem 174 (1997) 167-172
9. Wilkinson P.L., Moyers J.R., Ports T., Chatterjee K., Ullyott D., and Hamilton W.K. Rate-pressure product and myocardial oxygen consumption during surgery for coronary artery bypass. Circulation 60 (1979) 170-173
10. Lesauskaite V., Epistolato M.C., Ivanoviene L., and Tanganelli P. Apoptosis of cardiomyocytes in explanted and transplanted hearts. Comparison of results from in situ TUNEL, ISEL, and ISOL reactions. Am J Clin Pathol 121 (2004) 108-116
11. Halestrap A.P., McStay G.P., and Clarke S.J. The permeability transition pore complex: another view. Biochimie 84 (2002) 153-166
12. Jayaraman T., and Marks A.R. Calcineurin is downstream of the inositol 1,4,5-trisphosphate receptor in the apoptotic and cell growth pathways. J Biol Chem 275 (2000) 6417-6420
13. Shibasaki F., Kondo E., Akagi T., and McKeon F. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature 386 (1997) 728-731
14. Shibasaki F., and McKeon F. Calcineurin functions in Ca(2+)-activated cell death in mammalian cells. J Cell Biol 131 (1995) 735-743
15. Wang H.G., Pathan N., Ethell I.M., et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284 (1999) 339-343
16. Lotem J., Kama R., and Sachs L. Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin. Proc Natl Acad Sci USA 96 (1999) 12016-12020
17. Halestrap A.P., Clarke S.J., and Javadov S.A. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res 61 (2004) 372-385
18. Nathan M., Friehs I., Choi Y.H., et al. Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. Ann Thorac Surg 79 (2005) 1620-1626
19. Tachibana T., Shiiya N., Kunihara T., et al. Immunophilin ligands FK506 and cyclosporine A improve neurologic outcome after transient spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 129 (2005) 123-128
20. Di Lisa F., and Bernardi P. Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole. Cardiovasc Res 70 (2006) 191-199
21. Argaud L., Gateau-Roesch O., Raisky O., Loufouat J., Robert D., and Ovize M. Postconditioning inhibits mitochondrial permeability transition. Circulation 111 (2005) 194-197
22. Hausenloy D., Wynne A., Duchen M., and Yellon D. Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. Circulation 109 (2004) 1714-1717
23. Yellon D.M., and Hausenloy D.J. Myocardial reperfusion injury. N Engl J Med 357 (2007) 1121-1135
24. Shanmuganathan S., Hausenloy D.J., Duchen M.R., and Yellon D.M. Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. Am J Physiol Heart Circ Physiol 289 (2005) H237-H242
25. Schmitt J.P., Schroder J., Schunkert H., Birnbaum D.E., and Aebert H. Role of apoptosis in myocardial stunning after open heart surgery. Ann Thorac Surg 73 (2002) 1229-1235