Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin

Biochemical Journal

Volumn 382, Issue 1, 2004, Pages 183-189

  Vandegriff, Kim D ^a   Bellelli, Andrea ^b,c   Samaja, Michele ^d   Malavalli, Ashok ^a   Brunori, Maurizio ^b,c   Winslow, Robert M ^a,e  

^a SANGART INC   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Altered conformational states; Haemoglobin; Ligand binding kinetics; O 2 equilibrium binding; Poly(ethylene glycol); Poly(ethylene glycol) modified haemoglobin

Indexed keywords

DISSOCIATION RATES; HAEMOGLOBIN; KINETIC CONSTANTS; LIGANDS;

CELLS; MOLECULES; NITROGEN; OXYGEN; POLYETHYLENE GLYCOLS; SCAVENGING;

ENZYME KINETICS;

MACROGOL; MALEIMIDE; NITRIC OXIDE; HEMOGLOBIN; MACROGOL DERIVATIVE; MALEIMIDE DERIVATIVE; MALEIMIDE POLYETHYLENE GLYCOL MODIFIED HEMOGLOBIN, MP4; MALEIMIDE-POLYETHYLENE GLYCOL-MODIFIED HEMOGLOBIN, MP4; OXYGEN;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONJUGATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DENSITY GRADIENT CENTRIFUGATION; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; OXIDATION KINETICS; OXYGEN AFFINITY; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN DEGRADATION; STROMA CELL; CHEMISTRY; METABOLISM;

HEMOGLOBINS; HUMANS; MALEIMIDES; NITRIC OXIDE; OXYGEN; POLYETHYLENE GLYCOLS;

EID: 4344704521     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040156     Document Type: Article

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