Phytate reduces age-related cardiovascular calcification

Frontiers in Bioscience

Volumn 13, Issue 18, 2008, Pages 7115-7122

  Grases, Felix ^a   Sanchis, Pilar ^a   Perello, Joan ^a   Isern, Bernat ^a   Prieto, Rafel M ^a   Fernandez Palomeque, Carlos ^b   Saus, Carles ^b  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

Author keywords

Aging; Cardiovascular Calcification; Diet; Phytate; Prevention

Indexed keywords

RATTUS; RATTUS NORVEGICUS;

PHYTIC ACID;

AGING; ANIMAL; ANIMAL FOOD; AORTA; AORTA DISEASE; ARTICLE; CALCINOSIS; CARDIOVASCULAR DISEASE; DRUG EFFECT; MALE; ORAL DRUG ADMINISTRATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; WISTAR RAT;

ADMINISTRATION, ORAL; AGING; ANIMAL FEED; ANIMALS; AORTA; AORTIC DISEASES; CALCINOSIS; CARDIOVASCULAR DISEASES; MALE; PHYTIC ACID; RATS; RATS, WISTAR;

EID: 52049113417     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3214     Document Type: Article

References (54)

1. R. J. Elliott and L. T. McGrath: Calcification of the human thoracic aorta during aging. Calcif Tissue Int 54, 268-273 (1994) (Pubitemid 24097828)
2. P. Kieffer, A. Robert, C. Capdeville-Atkinson, J. Atkinson and I. Lartaud-Idjouadiene: Age-related arterial calcification in rats. Life Sci 66, 2371-2381 (2000) (Pubitemid 30252325)
3. A. Boon, E. Cheriex, J. Lodder and F. Kessels: Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 78, 472-474 (1997) (Pubitemid 27515107)
4. B. B. Tomazic: Physiochemical principles of cardiovascular calcification. Z Kardiol 90, 68-80 (2001)
5. H. Yoshitake, S. R. Rittling, D. T. Denhardt and M. Noda: Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Natl Acad of Sci U S A 96, 8156-8160 (1999) (Pubitemid 29328424)
6. F. P. Reinholt, K. Hultenby, A. Oldberg and D. Heinegard: Osteopontin - a possible anchor of osteoclasts to bone. Proc Natl Acad Sci U S A 87, 4473-4475 (1990)
7. C. M. Giachelli, N. Bae, M. Almeida, D. T. Denhardt, C. E. Alpers and S. M. Schwartz: Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J Clin Invest 92, 1686-1696 (1993) (Pubitemid 23304531)
8. K. D. O'Brien, J. Kuusisto, D. D. Reichenbach, M. Ferguson, C. Giachelli, C. E. Alpers and C. M. Otto: Osteopontin is expressed in human aortic valvular lesions. Circulation 92, 2163-2168 (1995)
9. C. M. Giachelli, M. Scatena and T. Wada: Osteopontin, potential roles in vascular function and dystrophic calcification. J Bone Miner Metab 15, 179-183 (1997) (Pubitemid 127502891)
10. H. Yasuda, N. Shima, N. Nakagawa, S. Mochizuki, K. Yano, N. Fujise, Y. Sato, M. Goto, K. Yamaguchi, M. Kuriyama, T. Kanno, A. Murakami, E. Tsuda, T. Morinaga and K. Higashio: Identify of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology 139, 1329-1337 (1998) (Pubitemid 28510154)
11. W. S. Simonet, D. L. Lacey, C. R. Dunstan, M. Kelley, M. S. Chang, R. Luthy, H. Q. Nguyen, S. Wooden, L. Bennett, T. Boone, G. Shimamoto, M. DeRose, R. Elliott, A. Colombero, H. L. Tan, G. Trail, J. Sullivan, E. Davy, N. Bucay, L. Renshaw-Gegg, T. M. Hughes, D. Hill, W. Pattison, P. Campbell, S. Sander, G. Van, J. Tarpley, P. Derby, R. Lee and W. J. Boyle: Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309-319 (1997) (Pubitemid 27199902)
12. N. Bucay, I. Sarosi, C. R. Dunstan, S. Morony, J. Tarpley, C. Capparelli, S. Scully, H. L. Tan, W. Xu, D. L. Lacey, W. J. Boyle and W. S. Simonet: Osteoprotegerindeficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12, 1260-1268 (1998) (Pubitemid 28213402)
13. G. Luo, P. Ducy, M. D. McKee, G. J. Pinero, E. Loyer, R. R. Behringer and G. Karsenty: Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386, 78-81 (1997) (Pubitemid 27130923)
14. A. F. Zebboudj, M. Imura and K. Bostrom: Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem 277, 4388-4394 (2002) (Pubitemid 34968705)
15. P. A. Price, S. A. Faus and M. K. Williamson: Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol 18, 1400-1407 (1998) (Pubitemid 28421877)
16. R. J. Levy, F. J. Schoen, J. T. Levy, A. C. Nelson, S. L. Howard and L. J. Oshry: Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats. Am J Pathol 113, 143-155 (1983) (Pubitemid 13023450)
17. A. P. Gadeau, H. Chaulet, D. Daret, M. Kockx, J. M. Daniel-Lamaziere and C. Desgranges: Time course of osteopontin, osteocalcin, and osteonectin accumulation and calcification after acute vessel wall injury. J Histochem Cytochem 49, 79-86 (2001) (Pubitemid 32012843)
18. A. L. Boskey, M. Maresca, W. Ullrich, S. B. Doty, W. T. Butler and C. W. Prince: Osteopontin-hydroxyapatite interactions in vitro: inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner 22, 147-159 (1993) (Pubitemid 23272798)
19. G. K. Hunter and H. A. Goldberg: Nucleation of hydroxyapatite by bone sialoprotein. Proc Natl Acad Sci U S A 90, 8562-8565 (1993) (Pubitemid 23277709)
20. G. K. Hunter, P. V. Hauschka, L. C. Rosenberg, A. R. Poole and H. A. Goldberg: Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem J 317, 59-64 (1996) (Pubitemid 26238329)
21. A. Govindaraj and R. Selvam: An oxalate-binding protein with crystal growth promoter activity from human kidney stone matrix. BJU Int 90, 336-344 (2002) (Pubitemid 34989086)
22. T. Yamate, K. Kohri, T. Umekawa, N. Amasaki, N. Amasaki, Y. Isikawa, M. Iguchi and T. Kurita: The effect of osteopontin on the adhesion of calcium oxalate crystals to Madin-Darby canine kidney cells. Eur Urol 30, 388-393 (1996) (Pubitemid 26362884)
23. J. C. Lieske, F. G. Toback and S. Deganello: Sialic acid-containing glycoproteins on renal cells determine nucleation of calcium oxalate dihydrate crystals. Kidney Int 60, 1784-1791 (2001) (Pubitemid 32999983)
24. K. A. Lomashvili, S. Cobbs, R.A. Hennigar, K.I. Hardcastle and W. C. O'Neill: Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin. J Am Soc Nephrol 15, 1392-1401 (2004) (Pubitemid 38679664)
25. D. Schibler, R. G. G. Russell and H. Fleisch: Inhibition by pyrophosphate and polyphosphate of aortic calcification induced by vitamin D3 in rats. Clin Sci 35, 363-372 (1968)
26. H. Fleisch, D. Schibler, J. Maerki and I. Frossard: Inhibition of aortic calcification by means of pyrophosphate and polyphosphates. Nature 207, 1300-1301 (1965)
27. P. A. Price, J. R. Buckley and M. K. Williamson: The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats. J Nutr 131, 2910-2915 (2001) (Pubitemid 33063122)
28. P. A. Price, S. A. Faus and M. K. Williamson: Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol 21, 817-824 (2001) (Pubitemid 32448773)
29. M. Bevilacqua, L. J. Dominguez, S. Rosini and M. Barbagallo: Bisphosphonates and atherosclerosis: why? Lupus 14, 773-779 (2005) (Pubitemid 41413310)
30. P. A. Price, A. M. Roublick and M. K. Williamson: Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate. Kidney Int 70, 1577-1583 (2006) (Pubitemid 44606992)
31. F. Grases, P. Sanchis, J. Perello, B. Isern, R. M. Prieto, C. Fernandez-Palomeque, M. Fiol, O. Bonnin and J. J. Torres: Phytate (myo-inositol hexakisphosphate) inhibits cardiovascular calcifications in rats. Front Biosci 11, 136-142 (2006) (Pubitemid 43253481)
32. F. Grases, P. Sanchis, J. Perello, B. Isern, R. M. Prieto, C. Fernandez-Palomeque and J. J. Torres: Effect of crystallization inhibitors on vascular calcifications induced by vitamin D: A Pilot Study in Sprague-Dawley Rats. Circ J 71, 1152-1156 (2007) (Pubitemid 46998036)
33. R. Rosenhek, U. Klaar, M. Schemper, C. Scholten, M. Heger, H. Gabriel, T. Binder, G. Maurer and H. Baumgartner: Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography. Eur Heart J 25, 185-187 (2004)
34. H. Fleisch and S. Bisaz: Isolation from urine of pyrophosphate, a calcification inhibitor. Am J Physiol 203, 671-675 (1962)
35. H. Fleisch and W. F. Neuman: Mechanism of calcification: role of collagen, polyphosphates, and phosphatases. Am J Physiol 200, 1296-1300 (1961)
36. H. A. Fleisch, R. G. Russell, S. Bisaz, R. C. Muhlbauer and D. A. Williams: The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. Eur J Clin Invest 1, 12-18 (1970)
37. F. Grases, R. M. Prieto, B. M. Simonet and J. G. March: Phytate prevents tissue calcifications in female rats. Biofactors 11, 171-177 (2000) (Pubitemid 30365965)
38. F. Grases, J. Perello, R. M. Prieto, B. M. Simonet and J. J. Torres: Dietary myo-inositol hexaphosphate prevents dystrophic calcifications in soft tissues: a pilot study in Wistar rats. Life Sci 75, 11-19 (2004) (Pubitemid 38501761)
39. J. M. Van Gelder, E. Breuer, A. Ornoy, A. Schlossman, N. Patlas and G. Golomb: Anticalcification and antiresorption effects of bisacylphosphonates. Bone 16, 511-520 (1995)
40. F. Grases, B. M. Simonet, R. M. Prieto and J. G. March: Variation of InsP4, InsP5 and InsP6 levels in tissues and biological fluids depending on dietary phytate. J Nutr Biochem 12, 595-601 (2001) (Pubitemid 32930055)
41. F. Grases, B. M. Simonet, I. Vucenik, R. M. Prieto, A. Costa-Bauza, J. G. March and A. M. Shamsuddin: Absorption and excretion of orally administered inositol hexaphosphate (IP6 or phytate) in humans. Biofactors 15, 53-61 (2001) (Pubitemid 34014664)
42. F. Grases, B. Isern, J. Perello, P. Sanchis and R. M. Prieto: Absorption of myo-inositol hexakisphosphate (InsP6) through the skin: Study of the matrix effects. Mechanism of phytate topical absorption. Front Biosci 10, 799-802 (2005)
43. F. Grases, B. Isern, J. Perello, P. Sanchis and A. Costa- Bauza: Absorption of yo-inositol hexakisphosphate (InsP6) through the skin in humans. Pharmazie 61, 52-652 (2006)
44. F. Grases, B. M. Simonet, J. Perello, A. Costa-Bauza and R. M. Prieto: Effect of phytate on element bioavailability in the second generation of rats. J Trace Elem Med Biol 17, 229-234 (2004) (Pubitemid 38520261)
45. H. Ichikawa, S. Ohishi, O. Takahashi, H. Kobayashi, K. Yuzawa, N. Hosokawa and T Hashimoto: Acute oral toxicities of phytic acid and sodium phytate in rats. Kenkyu Nenpo-Tokyo-toristu Eisei Kenkyusho 38, 371-376 (1987)
46. C. Fornieri, D. Jr. Quaglino and G. Mori: Role of extracellular matrix in age-related modifications of the rat aorta. Ultrastructural, morphometric, and enzymatic evaluations. Arterioscler Thromb Vasc Biol 12, 1008-1016 (1992)
47. J. Atkinson: Aging of arterial extracellular matrix elastin: causes and consequences. Pathol Biol 46, 555-559 (1998) (Pubitemid 28509086)
48. S. Najman, Lj. Dordevic, V. Savic, N. Ignjatovic, M. Plavsic and D. Uskokovic: Changes of HAp/PLLA biocomposites and tissue reaction after subcutaneous implantation. Facta Universitatis 10, 131-134 (2003)
49. I. Nadra, J. C. Mason, P. Philippidis, O. Florey, C. D. W. Smythe, G. M. McCarthy, R. C. Landis and D. O Haskard: Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res 96, 1248-1256 (2005) (Pubitemid 40962102)
50. Y. B. Sun, X. R. Zeng, L. Wenger and H. S. Cheung: Basic calcium phosphate crystals stimulate the endocytotic activity of cells-inhibition by anti-calcification agents. Biochem Biophys Res Commun 312, 1053-1059 (2003) (Pubitemid 37490922)
51. E. Graf E and J. W. Eaton: Antioxidant functions of phytic acid. Free Radic Biol Med 8, 61-69 (1990)
52. L. M. Steffen, D. R. Jr. Jacobs, J. Stevens, E. Shahar, T. Carithers and A. R. Folsom: Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: The atherosclerosis risk in communities (ARIC) study. Am J Clin Nutr 78, 383-390 (2003) (Pubitemid 39663503)
53. E. B. Rimm, A. Ascherio, E. Giovannucci, D. Spiegelman, M. J. Stampfer and W. C. Willett: Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA 275, 447-451 (1996) (Pubitemid 26065617)
54. D. R. Jacobs, M. A. Pereira, K. A. Meyer and L. H. Kushi: Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: the Iowa women's health study. J Am Coll Nutr 19, 326S-330S (2000) (Pubitemid 30399589)