Impact of ethnicity and MTHFR genotype on age at onset of coronary artery disease in women in Israel

Israel Medical Association Journal

Volumn 10, Issue 7, 2008, Pages 516-519

  Mager, Aviv ^a,b   Koren Morag, Nira ^a,b   Shohat, Mordechai ^a,b   Dadashev, Alexander ^a,b   Kornowski, Ran ^a,b   Battler, Alexander ^a,b   Hasdai, David ^a,b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Coronary artery disease; Ethnicity; Genetics; Methylenetetrahydrofolate reductase; Women

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; ETHNICITY; FEMALE; GENE MUTATION; GENOTYPE; HUMAN; ISRAEL; JEW; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; ONSET AGE; RISK ASSESSMENT; RISK FACTOR; SAMPLE SIZE; AGE; COMPARATIVE STUDY; ETHNIC GROUP; ETHNOLOGY; GENETICS; MIDDLE AGED; SEX DIFFERENCE;

AGE FACTORS; AGE OF ONSET; CORONARY ARTERY DISEASE; DNA; ETHNIC GROUPS; FEMALE; GENOTYPE; HUMANS; ISRAEL; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS;

EID: 52049106689     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Stampfer MJ, Malinow MR, Willet WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 1992;268:877-81.
2. Arnesen E, Refsum H, Bonaa KH, Ueland PM, Forde OH, Nordrehaug JE. Serum total homocysteine and coronary artery disease. Int J Epidemiol 1995;24:704-9.
3. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
4. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997;337:230-6.
5. Frosst P, Blom HJ, Milos R, et al. Candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase gene. Nat Genet 1995;10:111-13.
6. Christensen B, Frosst P, Lussier-Cacan S, et al. Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol 1997;17:569-73.
7. Ma J, Stampfer MJ, Hennekens CH, et al. Methylenetetrahydrofola te reductase polymorphism, plasma folate, homocysteine and risk of myocardial infarction in US physicians. Circulation 1996;94:2410-16.
8. Kluijtmans LA, Van den Heuvel LP, Boers GH, et al. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 1996;58:17-20.
9. Kluijtmans LA, Kastelein JJ, Lindemans J, et al. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1997;96:2573-7.
10. Gallagher PM, Meleady R, Shields DC, et al. Homocysteine and the risk of premature coronary heart disease. Circulation 1996;94:2154-8.
11. Izumi M, Iwai N, Ohmichi N, Nakamura Y, Shimoike H, Kinoshita M. Molecular variant of 5,10-methylenetetrahydrofolate reductase is a risk factor of ischemic heart disease in the Japanese population. Atheroslerosis1996;121:293-4.
12. Morita H, Taguchi J, Kurihara H, et al. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 1997;95:2032-6.
13. Mager A, Lalezari S, Shohat T, et al. Methylenetetrahydrofolat e reductase genotypes and early-onset coronary artery disease. Circulation 1999;100:2406-10.
14. Tanis BC, Blom HJ, Bloemenkamp DG, et al. Folate, homocysteine levels methylenetetrahydrofolate reductase (MTHFR) 677 C->T variant and the risk of myocardial infarction in young women. Thromb Haemost 2004;2:35-41.
15. Schwartz SM, Siscovick DS, Malinow MR, et al. Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. Circulation 1997;96:412-17.
16. Terruzzi I, Senesi P, Fermo I, Lattuada G, Luzi L. Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity? J Endocrinol Invest 2007;30:747-53.
17. Ilhan N, Kucuksu M, Kaman D, Ilhan N, Ozbay Y. The 677C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. Arch Med Res 2008;39:125-30.
18. Pollak RD, Friedlander Y, Pollak A, Idelson M, Bejarano-Achache I, Blumenfeld A. Ethnic differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in healthy Israeli populations. Genet Test 2000;4:309-11.
19. Pollak RD, Pollak A, Idelson M, Bejarano-Achache I, Doron D, Blumenfeld A. The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia. J Am Geriatr Soc 2000 48:664-8.
20. Nakai K, Habano W, Nakai K, Fukushima N, Fujita T, Gurwitz D. Ethnic differences of coronary artery disease-associated SNPs in two Israeli healthy populations using MALDI-TOF mass spectrometry. Life Sci 2004;75:1003-10.
21. Seligsohn U, Zivelin A. Thrombophilia as a multigenic disorder. Thromb Haemost 1997;78:297-301.
22. Alroy S, Preis M, Barzilai M, et al. Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation. IMAJ 2007;9:321-5.
23. Russo GT, Friso S, Jacques PF, et al. Age and gender affect the relation between methyleneterahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring study cohort. J Nutr 2003;133:3416-21.
24. Mager A, Battler A, Birnbaum Y, Magal N, Shohat M. Plasma homocysteine, methylenetetrahydrofolate reductase genotypes and age at onset of symptoms of myocardial ischemia. Am J Cardiol 2002;89:919-23.