Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease

Circulation

Volumn 100, Issue 24, 1999, Pages 2406-2410

  Mager, Aviv ^a   Lalezari, Shadan ^a   Shohat, Tamar ^a   Birnbaum, Yochai ^a   Adler, Yehuda ^a   Magal, Nurit ^a   Shohat, Mordechai ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

Coronary disease; Genetics; Myocardial infarction; Risk factors

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; FOLIC ACID;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DYSLIPIDEMIA; FAMILY HISTORY; FEMALE; FOLIC ACID BLOOD LEVEL; GENE MUTATION; GENETIC ANALYSIS; HOMOZYGOSITY; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SMOKING;

EID: 0032763113     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.100.24.2406     Document Type: Article

References (25)

1. Stampfer MJ, Malinow MR, Willet WC, Newcomer LM, Upson B, Ullman D, Tishler PV, Hennekens CH. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992;268:887-881.
2. Arensen E, Refsum H, Bonaa KH, Ueland PM, Forde OH, Nordrehaug JE. Serum total homocysteine and coronary artery disease. Int J Epidemiol. 1995;24:704-709.
3. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995;274: 1049-1057.
4. Verhoef P, Hennekens CH, Malinow MR, Kok FJ, Willet WC, Stampfer MJ. A prospective study of homocyst(e)ine and risk of ischemic stroke. Stroke. 1994;25:1924-1930.
5. den Heijer M, Koster T, Blom HJ, Bos GM, Briet E, Reitsma PH, Vandenbrouke JP, Rosendaal FR. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl J Med. 1996;334:759-762.
6. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollest SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230-236.
7. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GHJ, Den Heijer M, Kluitmans LAJ, Van den Heuvel LPWJ, Rosen R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase gene. Nat Genet. 1995; 10:111-113.
8. Christensen B, Frosst P, Luisier-Cacan S, Selhub J, Goyette P, Rosenblatt DS, Genest J, Rozen R. Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol. 1997;17:569-573.
9. van der Put NMJ, Eskes TKAB, Blom HJ. Is the common 677C→T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. QJM. 1997;90:111-115.
10. Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, Willet WC, Rozen R. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine and risk of myocardial infarction in US physicians. Circulation. 1996;94:2410-2416.
11. Kluitmans KLJ, Van den Heuvel LPWJ, Boers GHJ, Frosst P, Stevens EMB, van Oost BA, Den Heijer M, Trijbels FJM, Rozen R, Blom HJ. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate gene is as a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996;58:45-41.
12. Kluitmans KLJ, Kastelein JJP, Lindemans J, Boers GHJ, Heil SG, Brushke AVG, Jukema JW, Van den Heuvel LPWJ, Trijbels FJM, Boerma GJM, Verheugt FWA, Willems F, Blom HJ. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation. 1997;96:2573-2577.
13. Verhoef P, Kok FJ, Kluitmans LAJ, Blom HJ, Refsum H, Ueland PM, Kruyssen DACM. The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease. Atherosclerosis. 1997;132: 105-113.
14. Gallagher PM, Meleady R, Shields DC, Tan KS, McMaster D, Rosen R, Evans A, Graham IM, Whitehead AS. Homocysteine and the risk of premature coronary heart disease. Circulation. 1996;94:2154-2158.
15. Jaques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9.
16. Schwartz, Siscovick DS, Malinow R, Rosendaal FR, Beverly K, Hess D, Psaty BM, Longstreth WT, Koepsell TD, Ranghunatan TE, Reitsma PH. Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. Circulation. 1997;96:412-417.
17. Izumi M, Iwai N, Ohmichi N, Nakamura Y, Shimoike H, Kinoshita M. Molecular variant of 5,10-methylenetetrahydrofolate reductase is a risk factor of ischemic heart disease in the Japanese population. Atherosclerosis. 1996;121:293-294.
18. Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor coronary artery disease. Circulation. 1997;95:2032-2036.
19. van Boxmeer FM, Mamotte CDS, Vasikaran SD, Taylor RR. Methylenetetrahydrofolate reductase gene and coronary artery disease. Circulation. 1997;95:21-23.
20. Adams M, Smith PD, Martin D, Thompson JR, Lodwick D, Samani NJ. Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. QJM. 1996;89:437-444.
21. Anderson JL, King GJ, Thomson MJ, Todd M, Bair T, Muhlestein JB, Carlquist JF. A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction. J Am Coll Cardiol. 1997;30:1206-1211.
22. Brugada R, Marian AJ. A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis. 1997;128:107-112.
23. Schmitz C, Lindpaintner K, Verhoef P, Gaziano JM, Buring J. Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. Circulation. 1996;94:1812-1814.
24. Reinhardt D, Sigusch HH, Vogt SF, Farker K, Muller S, Hoffmann A. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease. Eur J Clin Invest. 1998;28:20-23.
25. Wilken DEL, Wang XL, Sim AS, McCredie RM. Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) mutation. Arterioscler Thromb Vasc Biol. 1996;16:878-882.