The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury

Biochemical Pharmacology

Volumn 75, Issue 4, 2008, Pages 981-995

  Gyamfi, Maxwell Afari ^a   Damjanov, Ivan ^a   French, Samuel ^b   Wan, Yu Jui Yvonne ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UCLA MEDICAL CENTER   (United States)

Author keywords

Acyl CoA oxidase; Alcoholic steatohepatitis; Ethanol; Liver fatty acid binding protein; Methionine choline deficient diet; Non alcoholic steatohepatitis; Steatosis

Indexed keywords

ALCOHOL; ALKALINE PHOSPHATASE; CHOLINE; FATTY ACID; GLUTATHIONE; INTERLEUKIN 6; LIPID PEROXIDE; MESSENGER RNA; METHIONINE; PROTEIN BCL 2; S ADENOSYLMETHIONINE; STAT3 PROTEIN;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT INJURY; CHOLESTASIS; CONTROLLED STUDY; FATTY LIVER; GENE EXPRESSION; HEPATITIS; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER REGENERATION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; BODY WEIGHT; CHOLINE DEFICIENCY; DIET; ETHANOL; FATTY LIVER; FATTY LIVER, ALCOHOLIC; GENE EXPRESSION; LIVER; LIVER FUNCTION TESTS; MALE; METHIONINE; MICE; MICE, INBRED STRAINS; ORGAN SIZE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 38649110476     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.09.030     Document Type: Article

References (64)

1. Arteel G., Marsano L., Mendez C., Bentley F., and McClain C.J. Advances in alcoholic liver disease. Best Pract Res 17 (2003) 625-647
2. Ludwig J., Viggiano T.R., McGill D.B., and Oh B.J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic Proc 55 (1980) 434-438
3. Chitturi S., and Farrell G.C. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 21 (2001) 27-41
4. Day C.P., and James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterology 114 (1998) 842-845
5. Weltman M.D., Farrell G.C., Hall P., Ingelman-Sundberg M., and Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27 (1998) 128-133
6. Yang S.Q., Lin H.Z., Lane M.D., Clemens M., and Diehl A.M. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 94 (1997) 2557-2562
7. Desvergne B., and Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20 (1999) 649-688
8. Mandard S., Muller M., and Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci 61 (2004) 393-416
9. Inoue M., Ohtake T., Motomura W., Takahashi N., Hosoki Y., Miyoshi S., et al. Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun 336 (2005) 215-222
10. Crabb D.W. Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease. Progr Liver Dis 13 (1995) 151-172
11. Ip E., Farrell G.C., Robertson G., Hall P., Kirsch R., and Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 38 (2003) 123-132
12. Nanji A.A., Dannenberg A.J., Jokelainen K., and Bass N.M. Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation. J Pharmacol Exp Therap 310 (2004) 417-424
13. Tanaka T., Masuzaki H., Ebihara K., Ogawa Y., Yasue S., Yukioka H., et al. Transgenic expression of mutant peroxisome proliferator-activated receptor gamma in liver precipitates fasting-induced steatosis but protects against high-fat diet-induced steatosis in mice. Metabol: Clin Exp 54 (2005) 1490-1498
14. Diehl A.M. Nonalcoholic fatty liver disease: implications for alcoholic liver disease pathogenesis. Alcohol Clin Exp Res 25 (2001) 8S-14S
15. Feldstein A.E., Canbay A., Angulo P., Taniai M., Burgart L.J., Lindor K.D., et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125 (2003) 437-443
16. Barak A.J., and Beckenhauer H.C. The influence of ethanol on hepatic transmethylation. Alcohol Alcohol 23 (1988) 73-77
17. Trimble K.C., Molloy A.M., Scott J.M., and Weir D.G. The effect of ethanol on one-carbon metabolism: increased methionine catabolism and lipotrope methyl-group wastage. Hepatology 18 (1993) 984-989
18. Weltman M.D., Farrell G.C., and Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 111 (1996) 1645-1653
19. Kojima H., Sakurai S., Uemura M., Takekawa T., Morimoto H., Tamagawa Y., et al. Difference and similarity between non-alcoholic steatohepatitis and alcoholic liver disease. Alcohol Clin Exp Res 29 (2005) 259S-263S
20. McMullen M.R., Pritchard M.T., Wang Q., Millward C.A., Croniger C.M., and Nagy L.E. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. Gastroenterology 128 (2005) 2066-2076
21. Zhou J., Zhai Y., Mu Y., Gong H., Uppal H., Toma D., et al. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem 281 (2006) 15013-15020
22. Sokol R.J., Devereaux M.W., Traber M.G., and Shikes R.H. Copper toxicity and lipid peroxidation in isolated rat hepatocytes: effect of vitamin E. Pediatr Res 25 (1989) 55-62
23. Gyamfi M.A., Kocsis M.G., He L., Dai G., Mendy A.J., and Wan Y.J. The role of retinoid X receptor alpha in regulating alcohol metabolism. J Pharmacol Exp Ther 319 (2006) 360-368
24. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249 (1974) 7130-7139
25. Reinke L.A., and Moyer M.J. p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab Dispos 13 (1985) 548-552
26. She Q.B., Nagao I., Hayakawa T., and Tsuge H. A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver. Biochem Biophys Res Commun 205 (1994) 1748-1754
27. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27 (1969) 502-522
28. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
29. Lieber C.S. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 77 (1997) 517-544
30. Leclercq I.A., Farrell G.C., Field J., Bell D.R., Gonzalez F.J., and Robertson G.R. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 105 (2000) 1067-1075
31. Cressman D.E., Greenbaum L.E., DeAngelis R.A., Ciliberto G., Furth E.E., Poli V., et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274 (1996) 1379-1383
32. Hong F., Jaruga B., Kim W.H., Radaeva S., El-Assal O.N., Tian Z., et al. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 110 (2002) 1503-1513
33. Vance J.E., and Vance D.E. The role of phosphatidylcholine biosynthesis in the secretion of lipoproteins from hepatocytes. Can J Biochem Cell Biol 63 (1985) 870-881
34. Yao Z.M., and Vance D.E. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 263 (1988) 2998-3004
35. Lu S.C., Huang Z.Z., Yang H., Mato J.M., Avila M.A., and Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol 279 (2000) G178-G185
36. Barak A.J., Beckenhauer H.C., and Tuma D.J. Methionine synthase. A possible prime site of the ethanolic lesion in liver. Alcohol 26 (2002) 65-67
37. Lieber C.S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 34 (2004) 9-19
38. Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15 (1995) 3012-3022
39. Fischer M., You M., Matsumoto M., and Crabb D.W. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 278 (2003) 27997-28004
40. Nakajima T., Kamijo Y., Tanaka N., Sugiyama E., Tanaka E., Kiyosawa K., et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 40 (2004) 972-980
41. Fan C.Y., Pan J., Chu R., Lee D., Kluckman K.D., Usuda N., et al. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem 271 (1996) 24698-24710
42. Wolfrum C., Buhlmann C., Rolf B., Borchers T., and Spener F. Variation of liver-type fatty acid binding protein content in the human hepatoma cell line HepG2 by peroxisome proliferators and antisense RNA affects the rate of fatty acid uptake. Bioch Biophys Acta 1437 (1999) 194-201
43. Reid A.E. Nonalcoholic steatohepatitis. Gastroenterology 121 (2001) 710-723
44. Anstee Q.M., and Goldin R.D. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol 87 (2006) 1-16
45. Rao M.S., and Reddy J.K. Peroxisomal beta-oxidation and steatohepatitis. Semin Liver Dis 21 (2001) 43-55
46. Mato J.M., Alvarez L., Ortiz P., and Pajares M.A. S-Adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol Therap 73 (1997) 265-280
47. Alvarez L., Corrales F., Martin-Duce A., and Mato J.M. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies. Biochem J 293 (1993) 481-486
48. Kotb M., Mudd S.H., Mato J.M., Geller A.M., Kredich N.M., Chou J.Y., et al. Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene products. Trends Genet 13 (1997) 51-52
49. Cai J., Mao Z., Hwang J.J., and Lu S.C. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cancer Res 58 (1998) 1444-1450
50. Huang Z.Z., Mato J.M., Kanel G., and Lu S.C. Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. Hepatology 29 (1999) 1471-1478
51. Sullivan D.M., and Hoffman J.L. Fractionation and kinetic properties of rat liver and kidney methionine adenosyltransferase isozymes. Biochemistry 22 (1983) 1636-1641
52. Colell A., Garcia-Ruiz C., Miranda M., Ardite E., Mari M., Morales A., et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115 (1998) 1541-1551
53. Teare J.P., Greenfield S.M., Watson D., Punchard N.A., Miller N., Rice-Evans C.A., et al. Lipid peroxidation in rats chronically fed ethanol. Gut 35 (1994) 1644-1647
54. Finkelstein J.D., Cello J.P., and Kyle W.E. Ethanol-induced changes in methionine metabolism in rat liver. Biochem Biophys Res Commun 61 (1974) 525-531
55. Corrales F., Gimenez A., Alvarez L., Caballeria J., Pajares M.A., Andreu H., et al. S-Adenosylmethionine treatment prevents carbon tetrachloride-induced S-adenosylmethionine synthetase inactivation and attenuates liver injury. Hepatology 16 (1992) 1022-1027
56. Halsted C.H., Villanueva J.A., Devlin A.M., Niemela O., Parkkila S., Garrow T.A., et al. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci USA 99 (2002) 10072-10077
57. McClain C.J., Barve S., Deaciuc I., Kugelmas M., and Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis 19 (1999) 205-219
58. McClain C., Barve S., Joshi-Barve S., Song Z., Deaciuc I., Chen T., et al. Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease. Alcohol Clin Exp Res 29 (2005) 180S-188S
59. Colantoni A., Idilman R., De Maria N., La Paglia N., Belmonte J., Wezeman F., et al. Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines. Alcohol Clin Exp Res 27 (2003) 1184-1189
60. Hill D.B., Marsano L., Cohen D., Allen J., Shedlofsky S., and McClain C.J. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. J Lab Clin Med 119 (1992) 547-552
61. Hong F., Kim W.H., Tian Z., Jaruga B., Ishac E., Shen X., et al. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins. Oncogene 21 (2002) 32-43
62. Hong F., Radaeva S., Pan H.N., Tian Z., Veech R., and Gao B. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology 40 (2004) 933-941
63. Sorrentino P., Tarantino G., Perrella A., Micheli P., Perrella O., and Conca P. A clinical-morphological study on cholestatic presentation of nonalcoholic fatty liver disease. Digest Dis Sci 50 (2005) 1130-1135
64. Wieckowska A., Zein N.N., Yerian L.M., Lopez A.R., McCullough A.J., and Feldstein A.E. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 44 (2006) 27-33