Mechanism of controlled drug release from a salting-out taste-masking system

Journal of Controlled Release

Volumn 131, Issue 1, 2008, Pages 47-53

  Yoshida, Takayuki ^a   Tasaki, Hiroaki ^a   Maeda, Atsushi ^a   Katsuma, Masataka ^a   Sako, Kazuhiro ^a   Uchida, Takahiro ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Immediate drug release; Lag time; Salt; Salting out effect; Taste masking; Water soluble polymer

Indexed keywords

BIOCHEMISTRY; CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; POLYMERS;

CONTROL LAYERS; CONTROLLED DRUG RELEASES; DRUG RELEASES; IMMEDIATE DRUG RELEASE; INSOLUBLE MATERIALS; LAG TIME; SALT; SALTING-OUT; SALTING-OUT EFFECT; SODIUM CARBONATES; TASTE-MASKING; WATER-SOLUBLE POLYMER; WATER-SOLUBLE POLYMERS;

TASTE CONTROL (WATER TREATMENT);

CITRIC ACID TRIETHYL ESTER; CITROFLEX 2; EUDRAGIT RS; HEXADECANOL; HYDROXYPROPYLMETHYLCELLULOSE; KALCOL 6098; PARACETAMOL; SC 60; SODIUM CARBONATE; TALC; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; DRUG FORMULATION; DRUG SOLUBILITY; MASKING; MICROSCOPY; PRIORITY JOURNAL; TASTE;

ACETAMINOPHEN; BIOLOGICAL AVAILABILITY; CARBONATES; DRUG DELIVERY SYSTEMS; METHYLCELLULOSE; PHARMACEUTICAL PREPARATIONS; SALTS; SOLUBILITY; TASTE; TIME FACTORS; WATER;

EID: 52049090332     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.07.009     Document Type: Article

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