Influences of Osmotic Agents in Diffusion Layer on Drug Release from Multilayer Coated Pellets

Drug Development and Industrial Pharmacy

Volumn 30, Issue 2, 2004, Pages 213-220

  Heng, Paul Wan Sia ^a   Hao, Jinsong ^a   Chan, Lai Wah ^a   Chew, Siok Hui ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Drug release; Multilayer coating; Osmotic agent; Pellet

Indexed keywords

CHLORPHENIRAMINE MALEATE; CITRIC ACID; DISODIUM HYDROGEN PHOSPHATE; EUDRAGIT; GLYCINE; HYDROXYPROPYLMETHYLCELLULOSE; OSMOTIC AGENT; POLYACRYLIC ACID; SODIUM CHLORIDE;

ARTICLE; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; OSMOLALITY; OSMOTIC PRESSURE;

ACRYLIC RESINS; ADJUVANTS, PHARMACEUTIC; CHEMISTRY, PHARMACEUTICAL; CHLORPHENIRAMINE; DELAYED-ACTION PREPARATIONS; DIFFUSION; METHYLCELLULOSE; MICROSPHERES; OSMOLAR CONCENTRATION; OSMOTIC PRESSURE; SOLUBILITY; VISCOSITY;

EID: 1842484849     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120028717     Document Type: Article

References (12)

1. McGinity, J.W. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 2nd Ed.; Marcel Dekker, Inc.: New York, 1997. Revised and Expanded.
2. Dittgen, M.; Durrani, M.; Lehmann, K. Acrylic polymers: a review of pharmaceutical applications. STP Pharma Sci. 1997, 7 (6), 403-437.
3. Verma, R.K.; Krishna, D.M.; Garg, S. Formulation aspects in the development of osmotically controlled oral drug delivery systems. J. Control. Release 2002, 79 (1-3), 7-27.
4. Narisawa, S.; Nagata, M.; Hirakawa, Y.; Kobayashi, M.; Yoshino, H. An organic acid-induced sigmoidal release system for oral controlled-release preparations. III. Elucidation of the anomalous drug release behaviour through osmotic pumping mechanism. Int. J. Pharm. 1997, 148 (1), 85-91.
5. Schulz, P.; Kleinebudde, P. A new multiparticulate delayed release system. I. Dissolution properties and release mechanism. J. Control. Release 1997, 47 (2), 181-189.
6. Tang, L.J.; Schwartz, J.B.; Porter, S.C.; Schnaare, R.L.; Wigent, R.J. Drug release from film-coated chlorpheniramine maleate nonpareil beads: effect of water-soluble polymer, coating level, and soluble core material. Pharm. Dev. Technol. 2000, 5 (3), 383-390.
7. Hjartstam, J.; Hjertberg, T. Swelling of pellets coated with a composite film containing ethyl cellulose and hydroxypropyl methylcellulose. Int. J. Pharm. 1998, 161 (1), 23-28.
8. Wan, L.S.C.; Tan, Y.T.F.; Heng, P.W.S. Drug release kinetics of bilayer-coated spheroids. STP Pharma Sci. 1998, 8 (2), 113-122.
9. Heng, P.W.S.; Chan, L.W.; Chew, S.H. Mechanism of pellet coat rupture and its effect on drug release. Chem. Pharm. Bull. 1999, 47 (7), 939-945.
10. Yuasa, H.; Nakano, T.; Kanaya, Y. Suppression of agglomeration in fluidized bed coating. II. Measurement of mist size in a fluidized bed chamber and effect of sodium chloride addition on mist size. Int. J. Pharm. 1999, 178 (1), 1-10.
11. Narisawa, S.; Nagata, M.; Hirakawa, Y.; Kobayashi, M.; Yoshino, H. An organic acid-induced sigmoidal release system for oral controlled-release preparations. II. Permeability enhancement of Eudragit RS coating led by the physicochemical interaction with organic acid. J. Pharm. Sci. 1996, 85 (2), 184-188.
12. Catellani, P.L.; Colombo, P.; Peppas, N.A.; Santi, P.; Bettini, R. Partial permselective coating adds an osmotic contribution to drug release from swellable matrixes. J. Pharm. Sci. 1998, 87 (6), 726-731.