Thymidylate synthase genotyping is more predictive for therapy response than immunohistochemistry in patients with colon cancer

International Journal of Cancer

Volumn 123, Issue 8, 2008, Pages 1941-1949

  Gosens, Marleen J ^a,b   Moerland, Elna ^b   Lemmens, Valery P ^c   Rutten, Harm T ^a   Tan Go, Ivonne ^b   Van Den Brule, Adriaan J ^b  

^a CATHARINA HOSPITAL   (Netherlands)

^b Stichting Laboratoria voor Pathologie en Medische Microbiologie   (Netherlands)

^c The Netherlands   (Netherlands)

Author keywords

5 fluorouracil; Colon cancer; Gene amplification; Polymorphism; Thymidylate synthase

Indexed keywords

FLUOROURACIL; FOLINIC ACID; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER PATIENT; CLINICAL ARTICLE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT; TUMOR RECURRENCE;

ADENOCARCINOMA; ADULT; AGED; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; DNA, NEOPLASM; FEMALE; FLUOROURACIL; GENE AMPLIFICATION; GENOTYPE; HUMANS; IMMUNOHISTOCHEMISTRY; LEUCOVORIN; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; THYMIDYLATE SYNTHASE;

EID: 51949105702     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23740     Document Type: Article

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