Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8745-8759

  LeDour, Gwennaël ^a   Moroy, Gautier ^a   Rouffet, Matthieu ^a   Bourguet, Erika ^a   Guillaume, Dominique ^a   Decarme, Martine ^a   ElMourabit, Haquima ^a   Augé, Franck ^a   Alix, Alain J P ^a   Laronze, Jean Yves ^a   Bellon, Georges ^a   Hornebeck, William ^a   Sapi, Janos ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Ilomastat; Matrix metalloproteinase; Molecular modeling; Selective MMP 9 inhibition; Sulfonylhydrazide; Zinc binding group

Indexed keywords

4 (4 BROMOPHENYL)BENZENESULFONYL DERIVATIVE; ALKYL GROUP; GELATINASE B; GELATINASE INHIBITOR; HYDRAZIDE DERIVATIVE; ILOMASTAT; N' [3 [2 (1H INDOL 3 YL) 1 (METHYLCARBAMOYL)ETHYLCARBAMOYL] 5 METHYLHEXANOYL] N 4 (4 BROMOPHENYL)BENZENESULFONYL HYDRAZIDE; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

ARTICLE; CHROMATOGRAPHY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL;

ALGORITHMS; BENZENE; HYDRAZINES; INDOLES; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 9; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

EID: 51849144056     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.041     Document Type: Article

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