Verbal working memory dysfunction in schizophrenia: An fMRI investigation

International Journal of Neuroscience

Volumn 118, Issue 10, 2008, Pages 1467-1487

  Pae, Chi Un ^a,b   Juh, Rahyeong ^c   Yoo, Seung Schik ^d   Choi, Byung Gil ^a   Lim, Hyun Kook ^a   Lee, Chul ^a   Paik, In Ho ^a   Jeun, Sin Su ^a   Lee, Chang Uk ^a  

^a The Catholic University of Korea   (South Korea)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c The Catholic University of Korea College of Medicine   (South Korea)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

fMRI; Schizophrenia; Working memory

Indexed keywords

CHLORPROMAZINE; OLANZAPINE; RISPERIDONE;

ADULT; ARTICLE; BLOOD OXYGENATION; BRAIN FUNCTION; BRAIN REGION; BRIEF PSYCHIATRIC RATING SCALE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ECHO PLANAR IMAGING; FEMALE; FRONTAL BONE; FRONTAL CORTEX; FRONTAL LOBE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INFORMATION PROCESSING; KOREA; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MINI MENTAL STATE EXAMINATION; NERVE CELL NETWORK; NUCLEAR MAGNETIC RESONANCE IMAGING; SCHIZOPHRENIA; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; TASK PERFORMANCE; TEMPORAL LOBE; VERBAL MEMORY; WORKING MEMORY;

ADOLESCENT; ADULT; BRAIN; BRAIN MAPPING; FEMALE; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MIDDLE AGED; MOTOR SKILLS; NEUROPSYCHOLOGICAL TESTS; OXYGEN; SCHIZOPHRENIA; VERBAL LEARNING; YOUNG ADULT;

EID: 51849141871     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.1080/00207450701591131     Document Type: Article

References (58)

1. Allen, G., Buxton, R. B., Wong, E. C., & Courchesne E. (1997). Attentional activation of the cerebellum independent of motor involvement. Science, 275, 1940-1943.
2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorder. 4th edition. Washington, DC: Author.
3. Andreasen, N. C., Rezai, K., & Alliger, R. (1992). Hypofrontality in neuroleptic-naive patients and in patient swith chronic schizophrenia. Archives of General Psychiatry, 49, 943-958.
4. Barch, D. M., Carter, C. S., & Braver, T. S. (2001). Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Archives of General Psychiatry, 58, 280-288.
5. Berman, K. F., Torrey, E. F., Daniel, D. G., & Weinberger, D. R. (1992). Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Archives of General Psychiatry, 49, 927-934.
6. Berman, K. F., Zec, R. F., & Weinberger, D. R. (1986). Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia II: Role of neuroleptic treatment, attention, and mental effort [see comments]. Archives of General Psychiatry, 43, 126-135.
7. Bertolino, A., Sciota, D., Brudaglio, F., Altamura, M., Blasi, G., Bellomo, A., et al. (2003). Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder. American Journal of Psychiatry, 160, 483-489.
8. Braus, D. F., Weber-Fahr, W., Tost, H., Ruf, M., & Henn, F. A. (2002). Sensory information processing in neuroleptic-naive, first-episode schizophrenic patients: A functional magnetic resonance imaging study. Archives of General Psychiatry, 59, 696-701.
9. Callicott, J. H., Bertolino, A., Mattay, V. S., Langheim, F. J., Duyn, J., Coppola, R., et al. (2000). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex, 10, 1078-1092.
10. Callicott, J. H., Mattay, V. S., Verchinski, B. A., Marenco, S., Egan, M. F., & Weinberger, D. (2003). Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down. American Journal of Psychiatry, 160, 2209-2215.
11. Callicott, J. H., Ramsey, N. F., & Tallent, K. (1998). Functional magnetic resonance imaging brain mapping in psychiatry: Methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology, 18, 186-196.
12. Carter, C., Robertson, L., Nordahl, T., Chaderjian, M., Kraft, L., & O'Shora-Celaya, L. (1996). Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients. Biological Psychiatry, 40, 930-932.
13. Carter, C. S., Perlstein, W., Ganguli, R., Brar, J., Mintun, M., & Cohen, J. D. (1998). Functional hypofrontality and working memory dysfunction in schizophrenia. American Journal of Psychiatry, 155, 1285-1287.
14. Collette, F., & Van Der Linden, M. (2002). Brain imaging of the central executive component of working memory. Neuroscience and Biobehavioral Reviews, 26, 105-125.
15. Courchesne, E., & Allen, G. (1997). Prediction and preparation, fundamental functions of the cerebellum. Learning and Memory, 4, 1-35.
16. Deicken, R. F., Feiwell, R., Schuff, N., & Soher, B. (2001). Evidence for altered cerebellar vermis neuronal integrity in schizophrenia. Psychiatry Research, 107, 125-134.
17. Desmond, J. E., & Glover, G. H. (2002). Estimating sample size in functional MRI (fMRI) neuroimaging studies: Statistical power analyses. Journal of Neuroscience Methods, 118, 115-128.
18. D'Esposito, M., Aguirre, G. K., Zarahn, E., Ballard, D., Shin, R. K., & Lease, J. (1998). Functional MRI studies of spatial and nonspatial working memory: Brain research. Cognitive Brain Research, 70, 1-13.
19. D'Esposito, M., Detre, J. A., Alsop, D. C., Shin, R. K., Atlas, S., & Grossman, M. (1995). The neural basis of the central executive system of working memory. Nature, 378, 279-281.
20. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1995). Structured clinical interview for DSM-IV axis I disorders - Non-patient edition (SCID-I/NP), version 2.0. New York: New York State Psychiatric Institute, Biometrics Research.
21. Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
22. Friedman, H. R., & Goldman-Rakic, P. S. (1994). Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey. Journal of Neuroscience, 14, 2775-2788.
23. Friston, K. J., Holmes, A. P., Price, C. J., Buchel, C., & Worsley, K. J. (1999a). Multisubject fMRI studies and conjunction analyses. Neuroimage, 10, 385-396.
24. Friston, K. J., Holmes, A. P., & Worsley, K. J. (1999b). How many subjects constitute a study? Neuroimage, 10, 1-5.
25. Gold, J. M., Wilk, C. M., McMahon, R. P., Buchanan, R. W., & Luck, S. J. (2003). Working memory for visual features and conjunctions in schizophrenia. Journal of Abnormal Psychology, 112, 61-71.
26. Goldberg, T. E., & Weinberger, D. R. (1996). Effects of neuroleptic medications on the cognition of patients with schizophrenia: A review of recent studies. Journal of Clinical Psychiatry, 57(Suppl. 9), 62-65.
27. Goldman-Rakic, P. (1991). Prefrontal cortical dysfuntion in schizophrenia: The relevance of working memory. In B. J. Carroll & J. E. Barrett (Eds.), Psychopathology and the Brain. New York: Raven Press.
28. Hollingshead, A. B. (1958). Two factor index of social position. New Haven, CT: Yale University Press.
29. Honey, G. D., Bullmore, E. T., & Sharma, T. (2002). De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia. Schizophrenia Research, 53, 45-56.
30. Kim, J. J., Andreasen, N. C., O'Leary, D. S., Wiser, A. K., Ponto, L. L., Watkins, G. L., et al. (1999). Direct comparison of the neural substrates of recognition memory for words and faces. Brain, 122, 1069-1083.
31. Koechlin, E., Basso, G., Pietrini, P., Panzer, S., & Grafman, J. (1999). The role of the anterior prefrontal cortex in human cognition. Nature, 399, 148-151.
32. MacDonald, A. W., , Carter, C. S., Kerns, J. G., Ursu, S., Barch, D. M., Holmes, A. J., et al. (2005). Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. American Journal of Psychiatry, 162, 475-484.
33. Manoach, D. S., Gollub, R. L., Benson, E. S., Searl, M. M., Goff, D. C., Halpern, E., et al. (2000). Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry, 48, 99-109.
34. Manoach, D. S., Press, D. Z., Thangaraj, V., Searl, M. M., Goff, D. C., Halpern, E., et al. (1999). Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry, 45, 1128-1137.
35. Mendrek, A., Laurens, K. R., Kiehl, K. A., Ngan, E. T., Stip, E., & Liddle, P. F. (2004). Changes in distributed neural circuitry function in patients with first-episode schizophrenia. British Journal of Psychiatry, 185, 205-214.
36. Menon, V., Anagnoson, R. T., Mathalon, D. H., Glover, G. H., & Pfefferbaum, A. (2001). Functional neuroanatomy of auditory working memory in schizophrenia: Relation to positive and negative symptoms. Neuroimage, 13, 433-446.
37. Okugawa, G., Sedvall, G., Nordstrom, M., Andreasen, N., Pierson, R., Magnotta, V., et al. (2002). Selective reduction of the posterior superior vermis in men with chronic schizophrenia. Schizophrenia Research, 55, 61-67.
38. Oldfield, R. C. (1971). The assessment and analysis of handedness: The Edinburg Inventory. Neuropsychologia, 9, 97-113.
39. Overall, J. E.,& Gorham, D. R. (1962). The brief psychiatric rating scale. Psychological Report, 10, 799-812.
40. Park, S., & Holzman, P. S. (1992). Schizophrenics shows patial working memory deficits. Archives of General Psychiatry, 49, 975-982.
41. Park, S., Holzman, P. S., & Goldman-Rakic, P. S. (1995). Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry, 52, 821-828.
42. Park, S., Puschel, J., Sauter, B. H., Rentsch, M., & Hell, D. (1999). Spatial working memory deficits and clinical symptoms in schizophrenia: A 4-months follow-up study. Biological Psychiatry, 46, 392-400.
43. Petrides, M., Alivisatos, B., Meyer, E., & Evans, A. C. (1993). Functional activation of the human prefrontal cortex during the performance of verbal working memory tasks. Proceedings of the National Academy of Sciences of the United States of America, 90, 878-882.
44. Poline, J. B., Worsley, K. J., Evans, A. C., & Friston, K. J. (1997). Combining spatial extent and peak intensity to test for activations in functional imaging. Neuroimage, 5, 83-96.
45. Quintana, J., Wong, T., Ortiz-Portillo, E., Kovalik, E., Davidson, T., Marder, S. R., et al. (2003a). Prefrontal-posterior parietal networks in schizophrenia: Primary dysfunctions and secondary compensations. Biological Psychiatry, 53, 12-24.
46. Quintana, J., Wong, T., Ortiz-Portillo, E., Marder, S. R., & Mazziotta, J. C. (2003b). Right lateral fusiform gyrus dysfunction during facial information processing in schizophrenia. Biological Psychiatry, 53, 1099-1112.
47. Ramsey, N. F., Koning, H. A., Welles, P., Cahn, W., Van Der Linden, J. A., & Kahn, R. S. (2002). Excessive recruitment of neural system subserving logical reasoning in schizophrenia. Brain, 125, 1793-1807.
48. Raven, J. C., Court, J. J., & Raven, J. (1995). Raven's progressive matrices and vocabulary scale. Oxford: Oxford Psychologists Press.
49. Schroder, J., Wenz, F., Schad, L. R., Baudendistel, K., & Knopp, M. V. (1995). Sensorimotor cortex and supplememtary motor area changes in schizophrenia: A study with functional magnetic resonance imaging. British Journal of Psychiatry, 167, 197-201.
50. Talairach, J., & Tournoux, P. (1988). Co-planar Stereotaxic Atlas of the Human Brain. New York: Thieme.
51. Weinberger, D. R., & Berman, K. F. (1996). Prefrontal function in schizophrenia: Confounds and controversies. Philosophical Transactions of the Royal Society of London: Series B; Biological Sciences, 351, 1495-1503.
52. Weinberger, D. R., Berman, K. F., & Illowsky, B. (1988). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia III: A new cohort and evidence for a monoaminergic mechanism. Archives of General Psychiatry, 45, 609-615.
53. Weinberger, D. R., Berman, K. F., & Zec, R. F. (1986). Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia I: Regional cerebral blood flow evidence. Archives of General Psychiatry, 43, 114-124.
54. Woodruff, P. W. R., Wright, I. C., Bullmore, E. T., Brammer, M., Howard, R. J., Williams, S. C. R., et al. (1997). Auditory hallucinations and the temporal cortical response to speech in schizophrenia: A functional magnetic resonance imaging study. American Journal of Psychiatry, 154, 1676-1682.
55. Worsley, K. (1995). Testing for a signal with unknown location and scale in a stationary Gaussian random field. Annals of Statistics, 23, 608-639.
56. Wright, I. C., Ellison, Z. R., Sharma, T., Friston, K. J., Murray, R. M., & McGuire, P. K. (1999). Mapping of gray matter changes in schizophrenia. Schizophrenia Research, 35, 1-14.
57. Yurgelun-Todd, D. A., & Renshaw, P. F. (1999). Applications of functional MR imaging to research in psychiatry. Neuroimaging Clinics of North America, 9, 295-308.
58. Yurgelun-Todd, D. A., Waternaux, C. M., Cohen, B. M., Gruber, S. A., English, C. D., & Renshaw, P. F. (1996). Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. American Journal of Psychiatry, 153, 200-205.