Synthesis of 3-aminoalkyl-2-arylaminoquiazolin-4(3H)-ones and 3,3′-disubstituted bis-2-arylaminoquinazolin-4(3H)-ones via reactions of 1-aryl-3-(2-ethoxycarbonylphenyl)carbodiimides with diamines

Journal of Heterocyclic Chemistry

Volumn 45, Issue 5, 2008, Pages 1365-1369

  Yang, Xu Hong ^a   Wu, Ming Hu ^a   Sun, Shao Fa ^a   Ding, Ming Wu ^b   Xie, Jia Li ^a   Xia, Qing Hua ^c  

^a HUBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CENTRAL CHINA NORMAL UNIVERSITY   (China)

^c HUBEI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYANAMIDE; ISOCYANATE; QUINAZOLINE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS; WITTIG REACTION; X RAY CRYSTALLOGRAPHY;

EID: 51849121581     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570450518     Document Type: Article

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45. The structure of 4e, which was recrystallized from MeOH, was determined by single-crystal X-ray diffraction analysis. Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2001); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: PLATON (Spek, 2003). Crystal data: C34H32N6O4, M = 558.66, Monoclinic, P2 (1)/c, a = 15.822(2) Å, b = 8.0024(7) Å, c = 23.7333(14) Å, α = 90°, β = 93.993(1)°, γ = 90°, V = 2997.6(5) Å3, Z = 4, Dcalcd = 1.304 g/cm3, 13493 collected reflections, 6514 independent (Rint = 0.0617), R1 = 0.0564, wR2 = 0.1171. The crystal data has been deposited in the Cambridge Crystallographic Data Centre as supplementary publication No. CCDC 668066. Copies of the data can be obtained, free of charge, via the internet (http://www.ccdc.cam.ac.uk/data_request/cif), by e-mail (data_request@ccdc.cam. ac.uk), or by fax (+44-1223-336033).