Subacute oral exposure to dibromoacetic acid induced immunotoxicity and apoptosis in the spleen and thymus of the mice

Toxicological Sciences

Volumn 105, Issue 2, 2008, Pages 331-341

  Gao, Shuying ^a   Wang, Yan ^a   Zhang, Ping ^a   Dong, Yucui ^a   Li, Baixiang ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Dibromoacetic acid; Immunotoxicity; Mice

Indexed keywords

ACETIC ACID DERIVATIVE; BETA ACTIN; DIBROMOACETIC ACID; FAS ANTIGEN; FAS LIGAND; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON MICROSCOPE; EXPOSURE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOTOXICITY; LYMPHOCYTE PROLIFERATION; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; SPLEEN; SPLEEN CELL; THYMOCYTE; THYMUS; WESTERN BLOTTING;

ACETIC ACIDS; ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD95; APOPTOSIS; ATROPHY; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; FEMALE; FLOW CYTOMETRY; LYMPHOCYTES; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; ORGAN SIZE; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SPLEEN; THYMUS GLAND; TNF RECEPTOR-ASSOCIATED FACTOR 2; WATER POLLUTANTS, CHEMICAL;

MUS;

EID: 51849088658     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn139     Document Type: Article

References (43)

1. Arora, H., Lechevalier, M., and Dixon, K. L. (1997). DBP occurrence survey. J. Am. Water Works Assoc. 89, 60-69.
2. Bertho, A. L., Santiago, M., and Coutinho, S. G. (2000). Flow cytometry in the study of cell death. Mem. Inst. Oswaldo Cruz Rio de Janerio 95(3), 429-433.
3. Blaylock, B. L., Holladay, S. D., Comment, C. E., Heindel, J., and Luster, I. M. (1992). Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation. Toxicol. Appl. Pharmacol. 112, 207-213.
4. Bodensteiner, K. J., Sawyer, H. R., Moeller, C. L., Kane, C. M., Pau, K.-Y. K. F., Kilnefelter, G. R., and Veeramachaneni, D. N. (2004). Chronic exposure to dibromoacetic acid, a water disinfection byproduct, diminishes primordial follicle populations in the rabbit. Toxicol. Sci. 80, 83-91.
5. Boorman, G. A. (1999). Drinking water disinfection byproducts: Review and approach to toxicity evaluation. Environ. Health Perspect. 107(Suppl. 1), 202-217.
6. Burchiel, S. W., Lauer, F. T., McDonald, J. D., and Reed, M. D. (2004). Systemic immunotoxicity in AJ mice following 6-month whole body inhalation exposure to diesel exhaust. Toxicol. Appl. Pharmacol. 196, 337-345.
7. Camacho, I. A., Nagarkatti, M., and Nagarkatti, P. S. (2004). Evidence for induction of apoptosis in T cells from murine fetal thymus following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Sci. 78, 96-106.
8. Castro, J. E., Listman, J. A., Jacobson, B. A., Wang, Y., Lopez, P. A., Ju, S., Finn, P. W., and Perkins, D. L. (1996). Fas modulation of apoptosis during negative selection of thymocytes. Immunity 5 617-627.
9. Chakrabarti, R., Jung, C. Y., Lee, T. P., Liu, H., and Mookerjee, B. K. (1994). Changes in glucose transport and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin. J. Immunol. 152, 2660-2668.
10. Christian, M. S., York, R. G., Hoberman, A. M., Frazee, J., Fisher, L. C., Brown, W. R., and Creasy, D. M. (2002). Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in rats. Int. J. Toxicol. 21, 237-276.
11. Cuff, C. F., Zhao, W., Nukui, T., Schafer, R., and Barnett, J. B. (1996). 3,4-Dichloropropionanilide-induced atrophy of the thymus: Mechanisms of toxicity and recovery. Fundam. Appl. Toxicol. 33 83-90.
12. Daniel, F. B., DeAngelo, A. B., Stober, J. A., Olson, G. R., and Page, N. P. (1992). Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the mate B6C3F1 mouse. Fundam. Appl. Toxicol. 19, 159-168.
13. DeAngelo, A. B., Daniel, F. B., Most, B. M., and Olson, G. R. (1996). The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat. Toxicology 114, 207-221.
14. + T cells: The roles of apoptosis, Fas, and TNF. Toxicology 170, 139-151.
15. US Environmental Protection Agency (US EPA). (2003). National Primary Drinking Water Regulations: Stage 2 Disinfectants and Disinfection By-Products (Stage 2 DBPR). Fed. Reg. 68, 49548-49681.
16. Fisher, M. T., Nagarkatti, M., and Nagarkatti, P. S. (2004). Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Toxicol. Sci. 78, 116-124.
17. Han, Y. C., Lin, T., and Pruett, S. (1993). Thymic atrophy caused by ethanol in a mouse model for binge drinking: Involvement of endogenous glucocorticoids. Toxicol. Appl. Pharmacol. 123, 16-25.
18. Herren-Freund, S. L., Pereira, M. A., Khoury, M. D., and Olson, G. (1987). The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid in mouse liver. Toxicol. Appl. Pharmacol. 90, 183-189.
19. Holmes, M., Suarez, J. D., Roberts, N. L., Moles, M. L., Murr, A. S., and Klinefelter, G. R. (2001). Dibromoacetic acid, a prevalent by-product of drinking water disinfection, compromises the synthesis of specific seminiferous tubule proteins following both in vivo and in vitro exposures. J. Andrology 22, 878-890.
20. Ju, S. T., Matsui, K., and Ozdemirli, M. (1999). Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction. Int. Rev. Immunol. 18, 485-513.
21. Kamath, A. B., Xu, H., Nagarkatti, P. S., and Nagarkatti, M. (1997). Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzop-dioxin in vivo. Toxicol. Appl. Pharmacol. 142, 367-377.
22. Klinefelter, G. R., Strader, L. F., Suarez, J. D., Roberts, N. L., Goldman, J. M., and Murr, A. S. (2004). Continuous exposure to dibromoacetic acid delay pubertal development and compromises sperm quality in rat. Toxicol. Sci. 81, 419-429.
23. Linder, R. E., Klinefelter, G. R., Strader, L. F., Suarez, J. D., Roberts, N. L., and Dyer, C. J. (1994). Spermatotoxicity of dibromoacetic acid in rats after 14 daily exposures. Reprod. Toxicol. 8, 251-259.
24. Luster, M. I., Portier, C., Pait, G. D., White, K. L., Jr., Gennings, C., Munson, A. E., and Rosenthal, G. J. (1992). Risk assessment in immunotoxicology I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 18, 200-210.
25. Melnick, R. L., Nyska, A., Foster, P. M., Roycroft, J. H., and Kissling, G. E. (2007). Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice. Toxicology 230 126-136.
26. Moser, V. C., Phillips, P. M., Levine, A. B., McDaniel, K. L., Sills, R. C., Jortner, B. S., and Butt, M. T. (2004). Neurotoxicity produced by dibromoacetic acid in drinking water of rats. Toxicol. Sci. 79 112-122.
27. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
28. National Toxicology Program (NTP). (2007). NTP toxicology and carcinogenesis studies of dibromoacetic acid (CAS No. 631-64-1) in F344/ N rats and W6C3F1 mice (drinking water studies). Natl. Toxicol. Program Tech. Rep. Ser. 537, 1-320.
29. Newton, K., Harris, A. W., Bath, M. L., Smith, K. G., and Strasser, A. (1998). A dominant interfering mutant of FADD/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17, 706-718.
30. Nieuwenhuijsen, M. J., Toledano, M. B., Eaton, N. E., Fawell, J., and Elliott, P. (2000). Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: A review. Occup. Environ. Med. 57, 73-85.
31. Okasha, S. A., Ryu, S., Do, Y., McKallip, R. J., Nagarkatti, M., and Nagarkatti, P. S. (2001). Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus. Toxicology 163 49-62.
32. Palmer, E. (2003). Negative selection - clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3, 383-391.
33. Pathak, N., and Khandelwal, S. (2007). Role of oxidative stress and apoptosis in cadmium induced thymic atrophy and splenomegaly in mice. Toxicol. Lett. 169, 95-108.
34. Richardson, S. D., Thruston, A. D., Jr., Rav-Acha, C., Groisman, L., Popilevsky, I., Juraev, O., Glezer, V., McKague, A. B., Plewa, M. J., and Wagner, E. D. (2003). Tribromopyrrole, brominated acids, and other disinfection byproducts produced by disinfection of drinking water rich in bromide. Environ. Sci. Technol. 37, 3782-3793.
35. Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocki, E., Murakami, K., Au, P. Y., Berry, D. M., Tamblyn, L., Shehabeldin, A., Migon, E., et al. (2003). Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 17(7), 883-895.
36. Steller, H. (1995). Mechanisms and genes of cellular suicide. Science (Washington DC) 267, 1445-1449.
37. Tryphonas, H., Luster, M. I., Schiffman, G., Dawson, L. L., Hodgen, M., Germolec, D., Hayward, S., Bryce, F., Loo, J. C., Mandy, F., et al. (1991). Effect of chronic exposure of PCB (aroclor 1254) on specific and nonspecific immune parameters in the rhesus (Macaca mulatta monkey. Fundam. Appl. Toxicol. 16, 773-786.
38. Vandebriel, R. J., Spiekstra, S. W., Hudspith, B. N., Meredith, C., and Van Loveren, H. (1999). In vitro exposure effects of cyclosporin A and bis(trin-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytes. Toxicology 135, 49-66.
39. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. (1995). A novel assay for apoptosis, flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein-labeled annexin V. J. Immunol. Methods 184, 39-45.
40. Visconti, A., Minervini, F., Lucivero, G., and Gambatesa, V. (1991). Cytotoxic and immunotoxic effects of Fusarium mycotoxins using a rapid colorimetric bioassay. Mycopathologia 113, 181-186.
41. Weinberg, H. S., Krasner, S. W., Richardson, S. D., and Thruston, A. D., Jr. (2002). In The occurrence of disinfection by-products (DBPs) of health concern in drinking water: Results of a Nationwide DBP occurrence study EPA/600/R-02/068
42. Wood, S. C., KarTas, J., and Holsapple, M. P. (1992). Integration of the human lymphocyte into immunotoxicological investigations. Fundam. Appl. Toxicol. 18, 450-459.
43. Zhang, J., Cado, D., Chen, A., Kabra, N. H., and Winoto, A. (1998). Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392, 296-300.